Skip Navigation LinksHome > April 2007 - Volume 19 - Issue 2 > Reproductive outcomes after in-vitro fertilization
Current Opinion in Obstetrics & Gynecology:
doi: 10.1097/GCO.0b013e32807fb199
Maternal-fetal medicine

Reproductive outcomes after in-vitro fertilization

Mukhopadhaya, Neelanjanaa; Arulkumaran, Sabaratnamb

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Purpose of review: This paper reviews the effect of in-vitro fertilization on maternal and perinatal outcomes of pregnancy.

Recent findings: Few randomized, controlled trials have been published in this area due to inherent difficulties in studying this population of infertile women who require in-vitro fertilization. Systematic review of the literature identified published studies that consistently highlighted the higher incidence of maternal and perinatal morbidity associated with pregnancies following in-vitro fertilization.

Summary: Some prospective observational studies compare maternal and perinatal outcomes in in-vitro fertilization pregnancies. Larger studies show that adverse pregnancy outcomes such as preeclampsia, gestational hypertension, placental abruption, placenta praevia, and preterm delivery increase significantly with in-vitro fertilization. Perinatal adverse outcomes such as prematurity and those related to plurality of the pregnancy also increase. All patients undergoing in-vitro fertilization should have careful counselling regarding these increased risks prior to treatment.

© 2007 Lippincott Williams & Wilkins, Inc.


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