Our understanding of the causes, mechanisms, and prenatal management of fetal obstructive uropathy has increased significantly. Improved methods of prenatal evaluation have allowed the better selection of fetuses for invasive therapy, and studies indicate better survival and renal outcomes in carefully selected cases. New biological markers in fetal urine may provide a better understanding of the pathological processes of renal damage, additional prognostic markers, and lead to non-surgical approaches to preventing renal damage.
aDepartment of Pediatric General and Thoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA; and b100 UCLA Medical Plaza, Los Angeles, CA, USA
Correspondence to Mark Paul Johnson, MD, Department of Pediatric General and Thoracic Surgery, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA Tel: +1-215-590-2747; fax: +1-215-590-4875