Skip Navigation LinksHome > June 2012 - Volume 25 - Issue 3 > Depression in headaches: chronification
Current Opinion in Neurology:
doi: 10.1097/WCO.0b013e328352c416
HEADACHE: Edited by Messoud Ashina

Depression in headaches: chronification

Deligianni, Christina I.; Vikelis, Michail; Mitsikostas, Dimos D.

Collapse Box


Purpose of review: Recent evidence supports the suggestion that migraine is a chronic disorder with episodic attacks that increase in frequency in a subgroup of patients, transforming migraine into a refractory chronic condition with poor outcome and severe impact. Among the risk factors for migraine chronification depression figures notably. Early diagnosis and management of risk factors in migraineurs prevent migraine chronification and its consequences. The scope of this article is to review depression as a potential cofactor for migraine chronification.

Recent findings: Population-based studies revealed that migraineurs often have symptoms of depression, with strongest associations for migraine with aura. Patients with depression also have an increased risk for migraine, migraine with aura in particular. Twin studies showed similar findings. This bidirectional relationship suggests that migraine and depression may share common causative factors, possibly genetically determined, that might control migraine chronification. Migraine patients may develop depression as a result of the demoralizing experience of recurrent and disabling headaches and depressed patients may develop migraine because of increased pain sensitivity, in the basis of a common genetic background.

Summary: We suggest that clinicians consider depression as part of migraine management in order to optimize treatment and avoid migraine progression.

© 2012 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.