You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Autonomic impairment in amyotrophic lateral sclerosis

Baltadzhieva, Rositsa; Gurevich, Tanya; Korczyn, Amos D

Current Opinion in Neurology:
Special commentary
Abstract

Purpose of review: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurones, but it is increasingly recognized to be a more disseminated disease. The autonomic nervous system may also be involved. Here we review the literature with specific emphasis on autonomic functions in ALS.

Recent studies: Ample evidence exists for subclinical dysfunction of cardiovascular, sudomotor, gastrointestinal, salivary and lacrimal regulation, even in early ALS cases. Autonomic disturbances may lead to circulatory collapse or sudden death in respirator dependent patients. Several studies suggest the existence of sympathetic hyperactivity in ALS. We discuss some possible pathophysiological mechanisms of the subtle abnormalities and some clinical and treatment implications.

Summary: The wide range of autonomic involvement, together with results suggesting cognitive and extrapyramidal dysfunction, supports the view that ALS is a multisystem degenerative disease.

Author Information

Neurology Department, Tel-Aviv Medical Center and the Sieratzki Chair of Neurology, Tel-Aviv University, Ramat-Aviv, Israel

Correspondence to Professor Amos D. Korczyn, Sieratzki Chair of Neurology, Tel-Aviv University Medical School, Ramat-Aviv 69978, Israel Tel: +972 3 6974229; fax: +972 3 6409113; e-mail: neuro13@post.tau.ac.il

© 2005 Lippincott Williams & Wilkins, Inc.