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The link between acute kidney injury and chronic kidney disease

Belayev, Linda Y.a; Palevsky, Paul M.a,b

Current Opinion in Nephrology and Hypertension: March 2014 - Volume 23 - Issue 2 - p 149–154
doi: 10.1097/01.mnh.0000441051.36783.f3
CLINICAL NEPHROLOGY: Edited by Bradley M. Denker

Purpose of review It has been argued that the existing epidemiologic data are insufficient to establish a causal link between acute kidney injury (AKI) and subsequent development or progression of chronic kidney disease (CKD), especially given that risk factors for the development of AKI overlap with those for progressive CKD.

Recent findings Multiple studies published over the past 5 years have demonstrated a strong epidemiologic association between episodes of AKI and subsequent development or progression of CKD, including evidence that severity of AKI and repeated episodes of AKI are associated with increased risk of CKD. In addition, animal models have provided evidence for a biological basis linking episodes of AKI with CKD.

Summary The preponderance of data support a causal link between episodes of AKI and subsequent development or progression of CKD.

aRenal-Electrolyte Division, University of Pittsburgh School of Medicine

bRenal Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA

Correspondence to Paul M. Palevsky, MD, Room 7E123 (111F-U), VA Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA. Tel: +1 412 360 3932; fax: +1 412 360 6130; e-mail: Palevsky@pitt.edu

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