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Current Opinion in Lipidology:
doi: 10.1097/MOL.0b013e32835cb4f6
CURRENT WORLD LITERATURE: Bibliography

Current World Literature

Free Access

This bibliography is compiled by clinicians from the relevant journals scanned by this publication. It is based on the literature regularly pulled into our database from OvidSP (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

▪ Papers considered by the reviewers to be of special interest

▪▪ Papers considered by the reviewers to be of outstanding interest

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

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Nutrition and metabolism
Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity

Review: (pp. 4–11)

Asgeirsson T, Zhang S, Khoo SK, Resau JH, et al. Serum Adiponectin, Resistin, and Circulating Soluble Receptor for Advanced Glycation End Products in Colectomy Patients - art. no. 916807. Mediat Inflamm 2011 16807.

Aydogan HY, Kucukhuseyin O, Tekeli A, Isbir T. Associations of Receptor for Advanced Glycation End Products -374 T/A and Gly82 Ser and Peroxisome Proliferator-Activated Receptor Gamma Pro12Ala Polymorphisms in Turkish Coronary Artery Disease Patients. Genet Test Mol Biomark 2012; 16:134–137.

Bansal S, Siddarth M, Chawla D, Banerjee BD, et al. Advanced glycation end products enhance reactive oxygen and nitrogen species generation in neutrophils in vitro. Mol Cell Biochem 2012; 361:289–296. PubMed | CrossRef

Basta G, Del Turco S, Marchi F, Navarra T, et al. Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I. Coronary Artery Dis 2011; 22:590–594. View Full Text | PubMed | CrossRef

Bhaskar JJ, Shobha MS, Sambaiah K, Salimath PV. Beneficial effects of banana (Musa sp var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats. J Physiol Biochem 2011; 67:415–425. PubMed | CrossRef

▪▪. Bierhaus A, Fleming T, Stoyanov S, et al. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med 2012; 18:926–933. [35]

Bondeva T, Wojciech S, Wolf G. Advanced glycation end products inhibit adhesion ability of differentiated podocytes in a neuropilin-1-dependent manner. Am J Physiol-Renal Physiol 2011; 301:F852–F870. PubMed | CrossRef

Bozhinov A, Handzhiyski Y, Genov K, Daskalovska V, et al. Advanced glycation end products contribute to the immunogenicity of IFN-beta pharmaceuticals. J Allergy Clin Immunol 2012; 129:855–858. View Full Text | PubMed | CrossRef

▪. Brouwers O, Niessen PM, Ferreira I, et al. Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats. J Biol Chem 2011; 286:1374–1380. [30]

Cai Q, Li BY, Gao HQ, Zhang JH, et al. Grape Seed Procyanidin B2 Inhibits Human Aortic Smooth Muscle Cell Proliferation and Migration Induced by Advanced Glycation End Products. Biosci Biotechnol Biochem 2011; 75:1692–1697. PubMed | CrossRef

Carnevale D, Mascio G, D'Andrea I, Fardella V, et al. Hypertension Induces Brain beta-Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature. Hypertension 2012; 60:188–197. View Full Text | PubMed | CrossRef

Carvalho VF, Florim LT, Barreto ED, Torres RC, et al. Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats. Eur J Pharmacol 2011; 669:143–148. View Full Text | PubMed | CrossRef

Celec P, Hodosy J, Jani P, Janega P, et al. Advanced glycation end products in myocardial reperfusion injury. Heart Vessels 2012; 27:208–215. PubMed | CrossRef

Chen PM, Zhao JB, Gregersen H. Up-Regulated Expression of Advanced Glycation End-Products and Their Receptor in the Small Intestine and Colon of Diabetic Rats. Dig Dis Sci 2012; 57:48–57. View Full Text | PubMed | CrossRef

Chiavaroli V, D'Adamo E, Giannini C, de Giorgis T, et al. Serum Levels of Receptors for Advanced Glycation End Products in Normal-Weight and Obese Children Born Small and Large for Gestational Age. Diabetes Care 2012; 35:1361–1363. View Full Text | PubMed | CrossRef

Christaki E, Lazaridis N, Opal SM. Receptor for advanced glycation end products in bacterial infection: is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis? Curr Opin Infect Dis 2012; 25:304–311.

Colhoun HM, Betteridge DJ, Durrington P, Hitman G, et al. Total Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products as Predictive Biomarkers of Coronary Heart Disease Risk in Patients With Type 2 Diabetes An Analysis From the CARDS Trial. Diabetes 2011; 60:2379–2385. View Full Text | PubMed | CrossRef

Coughlan MT, Patel SK, Jerums G, Penfold SA, et al. Advanced Glycation Urinary Protein-Bound Biomarkers and Severity of Diabetic Nephropathy in Man. Am J Nephrol 2011; 34:347–355. PubMed | CrossRef

Coughlan MT, Yap FYT, Tong DCK, Andrikopoulos S, et al. Advanced Glycation End Products Are Direct Modulators of beta-Cell Function. Diabetes 2011; 60:2523–2532. View Full Text | PubMed | CrossRef

Daniels SR. Screening and Treatment of Dyslipidemias in Children and Adolescents. Horm Res Paediatr 2011; 76:47–51.

De Benedictis G, Piazza O. May soluble form of the receptor for advanced glycation end products be considered a mediator of acute lung injury? Crit Care Med 2012; 40:354.

de Giorgis T, D'Adamo E, Giannini C, Chiavaroli V, et al. Could Receptors for Advanced Glycation End Products Be Considered Cardiovascular Risk Markers in Obese Children? Antioxid Redox Signal 2012; 17:187–191.

de Groot L, Hinkema H, Westra J, Smit AJ, et al. Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease - art. no. R205. Arthritis Res Ther 2011; 13:R205. PubMed | CrossRef

de Ranitz-Greven WL, Bos DC, Poucki WK, Visser GHA, et al. Advanced Glycation End Products, Measured as Skin Autofluorescence, at Diagnosis in Gestational Diabetes Mellitus Compared with Normal Pregnancy. Diabetes Technol Ther 2012; 14:43–49. PubMed | CrossRef

Diguet N, Mallat Y, Ladouce R, Clodic G, et al. Muscle Creatine Kinase Deficiency Triggers Both Actin Depolymerization and Desmin Disorganization by Advanced Glycation End Products in Dilated Cardiomyopathy. J Biol Chem 2011; 286:35007–35019. PubMed | CrossRef

Elangovan I, Thirugnanam S, Chen AS, Zheng GX, et al. Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth. Biochem Biophys Res Commun 2012; 417:1133–1138. PubMed | CrossRef

Feng B, Xu L, Wang H, Yan XF, et al. Atorvastatin exerts its anti-atherosclerotic effects by targeting the receptor for advanced glycation end products. Biochim Biophys Acta-Mol Basis Dis 2011; 1812:1130–1137. PubMed | CrossRef

Fleenor BS, Sindler AL, Eng JS, Nair DP, et al. Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products. Exp Gerontol 2012; 47:588–594. View Full Text | PubMed | CrossRef

Franke S, Ruster C, Pester J, Hofmann G, et al. Advanced glycation end products affect growth and function of osteoblasts. Clin Exp Rheumatol 2011; 29:650–660. PubMed

▪. Gaens KH, Niessen PM, Rensen SS, et al. Endogenous formation of Nepsilon-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis. J Hepatol 2012; 56:647–655. [36]

Gangemi S, Allegra A, Aguennouz M, Alonci A, et al. Relationship Between Advanced Oxidation Protein Products, Advanced Glycation End Products, and S-Nitrosylated Proteins With Biological Risk and MDR-1 Polymorphisms in Patients Affected by B-Chronic Lymphocytic Leukemia. Cancer Invest 2012; 30:20–26. PubMed | CrossRef

Glenn JV, Mahaffy H, Dasari S, Oliver M, et al. Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate. Graefes Arch Clin Exp Ophthalmol 2012; 250:349–359. PubMed | CrossRef

Grimm S, Horlacher M, Catalgol B, Hoehn A, et al. Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radic Biol Med 2012; 52:1011–1023. View Full Text | PubMed | CrossRef

Grote VA, Nieters A, Kaaks R, Tjonneland A, et al. The Associations of Advanced Glycation End Products and Its Soluble Receptor with Pancreatic Cancer Risk: A Case-Control Study within the Prospective EPIC Cohort. Cancer Epidemiol Biomarkers Prev 2012; 21:619–628. PubMed | CrossRef

Hayakawa E, Yoshimoto T, Sekizawa N, Sugiyama T, et al. Overexpression of Receptor for Advanced Glycation End Products Induces Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cell Line. J Atheroscler Thromb 2012; 19:13–22. PubMed | CrossRef

Henning C, Smuda M, Girndt M, Ulrich C, et al. Molecular Basis of Maillard Amide-Advanced Glycation End Product (AGE) Formation in Vivo. J Biol Chem 2011; 286:44350–44356. PubMed | CrossRef

Heo YJ, Oh HJ, Jung YO, Cho ML, et al. The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1 - art. no. R113. Arthritis Res Ther 2011; 13:R113. PubMed | CrossRef

Hiraiwa H, Sakai T, Mitsuyama H, Hamada T, et al. Inflammatory effect of advanced glycation end products on human meniscal cells from osteoarthritic knees. Inflamm Res 2011; 60:1039–1048. PubMed | CrossRef

Hirasawa Y, Sakai T, Ito M, Yoshimura H, et al. Advanced-glycation-end-product-cholesterol-aggregated-protein accelerates the proliferation of mesangial cells mediated by transforming-growth-factor-beta 1 receptors and the ERK-MAPK pathway. Eur J Pharmacol 2011; 672:159–168. View Full Text | PubMed | CrossRef

Hu PF, Lai DW, Lu PL, Gao J, et al. ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells. Int J Mol Med 2012; 29:613–618.

Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S. Rosuvastatin Blocks Advanced Glycation End Products-elicited Reduction of Macrophage Cholesterol Efflux by Suppressing NADPH Oxidase Activity via Inhibition of Geranylgeranylation of Rac-1. Horm Metab Res 2011; 43:619–624.

Ishibashi Y, Nishino Y, Matsui T, Takeuchi M, et al. Glucagon-like peptide-1 suppresses advanced glycation end product-induced monocyte chemoattractant protein-1 expression in mesangial cells by reducing advanced glycation end product receptor level. Metab-Clin Exp 2011; 60:1271–1277. PubMed | CrossRef

Jabaudon M, Futier E, Sapin V, Constantin JM. May soluble form of the receptor for advanced glycation end products be considered a mediator of acute lung injury? Reply. Crit Care Med 2012; 40:354–355. View Full Text | PubMed | CrossRef

Jeong SJ, Kim CO, Song YG, Baek JH, et al. Low plasma levels of the soluble receptor for advanced glycation end products in HIV-infected patients with subclinical carotid atherosclerosis receiving combined antiretroviral therapy. Atherosclerosis 2011; 219:778–783. PubMed | CrossRef

▪. Jia X, Chang T, Wilson TW, Wu L. Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1. PLoS One 2012; 7:e36610. [38]

Jung H, Joo J, Jeon Y, Lee J, et al. Advanced glycation end products downregulate glucokinase in mice. Diabetes-Metab Res Rev 2011; 27:557–563. PubMed | CrossRef

Jung HA, Park JJ, Islam MN, Jin SE, et al. Inhibitory Activity of Coumarins from Artemisia capillaris against Advanced Glycation Endproduct Formation. Arch Pharm Res 2012; 35:1021–1035. PubMed | CrossRef

Kalousova M, Kubena AA, Benakova H, Dusilova-Sulkova S, et al. EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study. Clin Biochem 2012; 45:556–560. PubMed | CrossRef

Kang R, Tang DL, Livesey KM, Schapiro NE, et al. The Receptor for Advanced Glycation End-Products (RAGE) Protects Pancreatic Tumor Cells Against Oxidative Injury. Antioxid Redox Signal 2011; 15:2175–2184. PubMed | CrossRef

Karimi J, Goodarzi MT, Tavilani H, Khodadadi I, et al. Increased receptor for advanced glycation end products in spermatozoa of diabetic men and its association with sperm nuclear DNA fragmentation. Andrologia 2012; 44:280–286. View Full Text | PubMed | CrossRef

Kim JK, Park S, Lee MJ, Song YR, et al. Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis. Atherosclerosis 2012; 220:208–214. PubMed | CrossRef

La Par DJ, Hajzus VA, Zhao YG, Lau CL, et al. Acute Hyperglycemic Exacerbation of Lung Ischemia-Reperfusion Injury Is Mediated by Receptor for Advanced Glycation End-Products Signaling. Am J Respir Cell Mol Biol 2012; 46:299–305.

Li H, Zhang XY, Guan XM, Cui XD, et al. Advanced glycation end products impair the migration, adhesion and secretion potentials of late endothelial progenitor cells - art. no. 46. Cardiovasc Diabetol 2012; 11:30.

Liao YC, Lee YH, Chuang LY, Guh JY, et al. Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells. Mol Cell Endocrinol 2012; 355:71–77. PubMed | CrossRef

Lin JG, Tang YC, Kong QH, Chen AP. Curcumin eliminates the inhibitory effect of advanced glycation end-products (AGEs) on gene expression of AGE receptor-1 in hepatic stellate cells in vitro. Lab Invest 2012; 92:827–841. PubMed | CrossRef

Lin LG, Zhong KH, Sun ZK, Wu GZ, et al. Receptor for advanced glycation end products (RAGE) partially mediates HMGB1-ERKs activation in clear cell renal cell carcinoma. J Cancer Res Clin Oncol 2012; 138:11–22. PubMed | CrossRef

Liu IM, Tzeng TF, Liou SS, Chang CJ. Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats - art. no. 140103. Evid-based Complement Altern Med 2012</date>40103.

Liu LH, Xie YX, Song ZQ, Shang SB, et al. Influence of dietary flavonoids on the glycation of plasma proteins. Mol Biosyst 2012; 8:2183–2187. PubMed

Liu Y, Ma YZ, Wang RT, Xia CH, et al. Advanced Glycation End Products Accelerate Ischemia/Reperfusion Injury Through Receptor of Advanced End Product/Nitrative Thioredoxin Inactivation in Cardiac Microvascular Endothelial Cells. Antioxid Redox Signal 2011; 15:1769–1778. PubMed | CrossRef

Mahali S, Raviprakash N, Raghavendra PB, Manna SK. Advanced Glycation End Products (AGEs) Induce Apoptosis via a Novel Pathway INVOLVEMENT OF CA(2+) MEDIATED BY INTERLEUKIN-8 PROTEIN. J Biol Chem 2011; 286:34903–34913. PubMed | CrossRef

Min JZ, Yamamoto M, Yu HF, Higashi T, et al. Rapid and sensitive determination of the intermediates of advanced glycation end products in the human nail by ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Anal Biochem 2012; 424:187–194. PubMed | CrossRef

Mizumoto S, Takahashi J, Sugahara K. Receptor for Advanced Glycation End Products (RAGE) Functions as Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or Sulfated Glycosaminoglycans Delivered in Vivo Inhibit Pulmonary Metastasis of Tumor Cells. J Biol Chem 2012; 287:18985–18994.

Moser B, Bekos C, Zimprich F, Nickl S, et al. The receptor for advanced glycation endproducts and its ligands in patients with myasthenia gravis. Biochem Biophys Res Commun 2012; 420:96–101. PubMed | CrossRef

Mu LL, Zhang Y, Sun B, Wang JH, et al. Activation of the receptor for advanced glycation end products (RAGE) exacerbates experimental autoimmune myasthenia gravis symptoms. Clin Immunol 2011; 141:36–48. PubMed | CrossRef

Nam MH, Lee HS, Seomun Y, Lee Y, et al. Monocyte-endothelium-smooth muscle cell interaction in co-culture: Proliferation and cytokine productions in response to advanced glycation end products. Biochim Biophys Acta-Gen Subj 2011; 1810:907–912. PubMed | CrossRef

Ng ZX, Kuppusamy UR, Tajunisah I, Fong KCS, et al. 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br J Ophthalmol 2012; 96:289–292. View Full Text | PubMed | CrossRef

Niu WQ, Qi Y, Wu ZJ, Liu Y, et al. A meta-analysis of receptor for advanced glycation end products gene: Four well-evaluated polymorphisms with diabetes mellitus. Mol Cell Endocrinol 2012; 358:9–17. PubMed | CrossRef

Nozynski J, Zakliczynski M, Konecka-Mrowka D. Reply to Bowman, et al. Advanced glycation end products in diabetic cardiomyopathy: An alternative hypothesis. J Heart Lung Transplant 2011; 30:1303–1304. PubMed | CrossRef

Obeid R, Shannan B, Herrmann W. Advanced glycation end products overload might explain intracellular cobalamin deficiency in renal dysfunction, diabetes and aging. Med Hypotheses 2011; 77:884–888. PubMed | CrossRef

Oborna I, Malickova K, Fingerova H, Brezinova J, et al. A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men. Am J Reprod Immunol 2011; 66:179–184. PubMed | CrossRef

Ojima A, Matsui T, Maeda S, Takeuchi M, et al. Glucose-dependent Insulinotropic Polypeptide (GIP) Inhibits Signaling Pathways of Advanced Glycation End Products (AGEs) in Endothelial Cells via its Antioxidative Properties. Horm Metab Res 2012; 44:501–505. PubMed | CrossRef

Padmaraju V, Bhaskar JJ, Rao U, Salimath PV, et al. Role of Advanced Glycation on Aggregation and DNA Binding Properties of alpha-Synuclein. J Alzheimers Dis 2011; 24:211–221. PubMed

Pazdro R, Burgess JR. Differential effects of alpha-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells. Biochim Biophys Acta-Mol Basis Dis 2012; 1822:550–556. PubMed | CrossRef

Prasad A, Bekker P, Tsimikas S. Advanced Glycation End Products and Diabetic Cardiovascular Disease. Cardiol Rev 2012; 20:177–183. View Full Text | PubMed | CrossRef

▪. Rabbani N, Thornalley PJ. Glyoxalase in diabetes, obesity and related disorders. Semin Cell Dev Biol 2011; 22:309–317. [28]

▪. Ramasamy R, Yan SF, Schmidt AM. The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes. Vascul Pharmacol 2012; 57:160–167.</source> [24]

Raposeiras-Roubin S, Barreiro-Parda C, Roubin-Camina F, Rodino-Janeiro BK, et al. Advanced glycation end products: A mysterious shadow beyond the relationship between HbA1c and atrial fibrillation. Int J Cardiol 2012; 157:441. PubMed | CrossRef

Raposeiras-Roubin S, Rodino-Janeiro BK, Grigorian-Shamagian L, Seoane-Blanco A, et al. Evidence for a role of advanced glycation end products in atrial fibrillation. Int J Cardiol 2012; 157:397–402.

Remor AP, de Matos FJ, Ghisoni K, da Silva TL, et al. Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: Involvement of advanced glycosylated end products. Biochim Biophys Acta-Mol Basis Dis 2011; 1812:1460–1471. PubMed | CrossRef

Reynolds PR, Kasteler SD, Schmitt RE, Hoidal JR. Receptor for Advanced Glycation End-Products Signals through Ras during Tobacco Smoke-Induced Pulmonary Inflammation. Am J Respir Cell Mol Biol 2011; 45:411–418.

Reynolds PR, Stogsdill JA, Stogsdill MP, Heimann NB. Up-Regulation of Receptors for Advanced Glycation End-Products by Alveolar Epithelium Influences Cytodifferentiation and Causes Severe Lung Hypoplasia. Am J Respir Cell Mol Biol 2011; 45:1195–1202.

Rojas A, Gonzalez I, Rodriguez B, Romero J, et al. Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells. Microbes Infect 2011; 13:818–823. PubMed | CrossRef

Sabbagh MN, Agro A, Bell J, Aisen PS, et al. PF-04494700, an Oral Inhibitor of Receptor for Advanced Glycation End Products (RAGE), in Alzheimer Disease. Alzheimer Dis Assoc Dis 2011; 25:206–212.

Sarkany Z, Ikonen TP, Ferreira-da-Silva F, Saraiva MJ, et al. Solution Structure of the Soluble Receptor for Advanced Glycation End Products (sRAGE). J Biol Chem 2011; 286:37525–37534. PubMed | CrossRef

Schalkwijk CG, Miyata T. Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics. Amino Acids 2012; 42: 1193–1204. PubMed | CrossRef

Selejan SR, Poss J, Hewera L, Kazakov A, et al. Role of receptor for advanced glycation end products in cardiogenic shock. Crit Care Med 2012; 40:1513–1522. View Full Text | PubMed | CrossRef

Semba RD, Ang A, Talegawkar S, Crasto C, et al. Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study. Eur J Clin Nutr 2012; 66:3–9. View Full Text | PubMed | CrossRef

Semba RD, Arab L, Sun K, Nicklett EJ, et al. Fat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product, in Adults. J Nutr 2011; 141:1726–1730. PubMed | CrossRef

Sheikpranbabu S, Haribalaganesh R, Banumathi E, Sirishkumar N, et al. Pigment epithelium-derived factor inhibits advanced glycation end-product-induced angiogenesis and stimulates apoptosis in retinal endothelial cells (Retraction of vol 85, pg 719, 2009). Life Sci 2011; 89:504. View Full Text | PubMed | CrossRef

Sheikpranbabu S, Haribalaganesh R, Gurunathan S. Pigment epithelium-derived factor inhibits advanced glycation end-products-induced cytotoxicity in retinal pericytes. Diabetes Metab 2011; 37:505–511. PubMed

Su XD, Li SS, Tian YQ, Zhang ZY, et al. Elevated Serum Levels of Advanced Glycation End Products and their Monocyte Receptors in Patients with Type 2 Diabetes. Arch Med Res 2011; 42:596–601. PubMed | CrossRef

Suga T, Iso T, Shimizu T, Tanaka T, et al. Activation of Receptor for Advanced Glycation End Products Induces Osteogenic Differentiation of Vascular Smooth Muscle Cells. J Atheroscler Thromb 2011; 18:670–683. PubMed | CrossRef

Sugihara T, Munesue S, Yamamoto Y, Sakurai S, et al. Endogenous Secretory Receptor for Advanced Glycation End-Products Inhibits Amyloid-beta(1-42) Uptake into Mouse Brain. J Alzheimers Dis 2012; 28:709–720. PubMed

Tahara N, Yamagishi S, Matsui T, Takeuchi M, et al. Serum Levels of Advanced Glycation End Products (AGEs) are Independent Correlates of Insulin Resistance in Nondiabetic Subjects. Cardiovasc Ther 2012; 30:42–48. View Full Text | PubMed | CrossRef

Tekabe Y, Luma J, Li Q, Schmidt AM, et al. Imaging of Receptors for Advanced Glycation End Products in Experimental Myocardial Ischemia and Reperfusion Injury. JACC-Cardiovasc Imag 2012; 5:59–67.

Tong ML, Wang YH, Wang YJ, Chen HY, et al. Genistein Attenuates Advanced Glycation End Product-Induced Expression of Fibronectin and Connective Tissue Growth Factor. Am J Nephrol 2012; 36:34–40. PubMed | CrossRef

Torres MC, Beltrame MH, Santos ICR, Picheth G, et al. Polymorphisms of the promoter and exon 3 of the receptor for advanced glycation end products (RAGE) in Euro- and Afro-Brazilians. Int J Immunogenet 2012; 39:155–160. View Full Text | PubMed | CrossRef

Ueda S, Yamagishi S, Matsui T, Noda Y, et al. Serum Levels of Advanced Glycation End Products (AGEs) are Inversely Associated with the Number and Migratory Activity of Circulating Endothelial Progenitor Cells in Apparently Healthy Subjects. Cardiovasc Ther 2012; 30:249–254. PubMed | CrossRef

Uribarri J, Cai WJ, Ramdas M, Goodman S, et al. Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes Potential role of AGER1 and SIRT1. Diabetes Care 2011; 34:1610–1616.

Vlassara H, Uribarri J, Cai WJ, Goodman S, et al. Effects of Sevelamer on HbA1c, Inflammation, and Advanced Glycation End Products in Diabetic Kidney Disease. Clin J Am Soc Nephrol 2012; 7:934–942. PubMed

Wang LJ, Li QQ, Du J, Chen B, et al. Advanced glycation end products induce moesin phosphorylation in murine retinal endothelium. Acta Diabetol 2012; 49:47–55. PubMed | CrossRef

Wang ZQ, Jiang YC, Liu NF, Ren LQ, et al. Advanced glycation end-product N-epsilon-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes. Atherosclerosis 2012; 221:387–396. PubMed | CrossRef

Willemsen S, Hartog JWL, Heiner-Fokkema MR, van Veldhuisen DJ, et al. Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome. Heart Fail Rev 2012; 17:221–228. PubMed | CrossRef

Xie CL, Liu NY, Long J, Tang C, et al. Blue native/SDS-PAGE combined with iTRAQ analysis reveals advanced glycation end-product-induced changes of synaptosome proteins in C57 BL/6 mice. Electrophoresis 2011; 32:2194–2205. PubMed | CrossRef

Xiong F, Leonov S, Howard AC, Xiong S, et al. Receptor for Advanced Glycation End Products (RAGE) Prevents Endothelial Cell Membrane Resealing and Regulates F-actin Remodeling in a beta-Catenin-dependent Manner. J Biol Chem 2011; 286:35061–35070.

Xu D, Young J, Song DY, Esko JD. Heparan Sulfate Is Essential for High Mobility Group Protein 1 (HMGB1) Signaling by the Receptor for Advanced Glycation End Products (RAGE). J Biol Chem 2011; 286:41736–41744. PubMed | CrossRef

Xu YH, Feng L, Wang SS, Zhu Q, et al. Phytoestrogen Calycosin-7-O-beta-D-Glucopyranoside Ameliorates Advanced Glycation End Products-Induced HUVEC Damage. J Cell Biochem 2011; 112:2953–2965. PubMed | CrossRef

Yamagishi S, Maeda S, Matsui T, Ueda S, et al. Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes. Biochim Biophys Acta-Gen Subj 2012; 1820:663–671. PubMed | CrossRef

Yan SJ, Wang L, Li Z, Zhu DN, et al. Inhibition of Advanced Glycation End Product Formation by Pu-erh Tea Ameliorates Progression of Experimental Diabetic Nephropathy. J Agric Food Chem 2012; 60:4102–4110. PubMed | CrossRef

Yoon SJ, Park S, Park C, Chang W, et al. Association of soluble receptor for advanced glycation end-product with increasing central aortic stiffness in hypertensive patients. Coronary Artery Dis 2012; 23:85–90. View Full Text | PubMed | CrossRef

Zhang F, Banker G, Liu XD, Suwanabol PA, et al. The Novel Function of Advanced Glycation End Products in Regulation of MMP-9 Production. J Surg Res 2011; 171:871–876. PubMed | CrossRef

Zhuang XY, Pang XF, Zhang W, Wu WB, et al. Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction. Life Sci 2012; 90:131–139. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Plant sterols and atherosclerosis

Review: (pp. 12–17)

Choudhary SP, Tran LS. Phytosterols: Perspectives in Human Nutrition and Clinical Therapy. Curr Med Chem 2011; 18:4557–4567. PubMed | CrossRef

Davis HR, Tershakovec AM, Tomassini JE, Musliner T. Intestinal sterol transporters and cholesterol absorption inhibition. Curr Opin Lipidology 2011; 22:467–478.

Devaraj S, Jialal I, Rockwood J, Zak D. Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity. Clin Nutr 2011; 30:668–671. PubMed | CrossRef

Eussen S, Feenstra TL, Toxopeus IB, Hoekstra J, et al. Costs and health effects of adding functional foods containing phytosterols/-stanols to statin therapy in the prevention of cardiovascular disease. Eur J Pharmacol 2011; 668: S91–S100. View Full Text | PubMed | CrossRef

▪▪. Genser B, Silbernagel G, De Backer G, et al. Plant sterols and cardiovascular disease: a systematic review and meta-analysis. Eur Heart J 2012; 33:444–451. [34]

Goedeke L, Fernandez-Hernando C. Regulation of cholesterol homeostasis. Cell Mol Life Sci 2012; 69:915–930. PubMed | CrossRef

Lottenberg AM, Bombo RPA, Ilha A, Nunes VS, et al. Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols? IUBMB Life 2012; 64:296–306.

▪. Mackay DS, Jones PJ. Plasma noncholesterol sterols: current uses, potential and need for standardization. Curr Opin Lipidol 2012; 23:241–247. [25]

MacKay DS, Jones PJH. Plasma noncholesterol sterols: current uses, potential and need for standardization. Curr Opin Lipidology 2012; 23:241–247.

▪. Miettinen TA, Nissinen M, Lepäntalo M, et al. Noncholesterol sterols in serum and endarterectomized carotid arteries after a short-term plant stanol and sterol ester challenge. Nutr Metab Cardiovasc Dis 2011; 21:182–188. [50]

Moore LL. Functional foods and cardiovascular disease risk: building the evidence base. Curr Opin Endocrinol Diabetes Obes 2011; 18:332–335. View Full Text | PubMed | CrossRef

▪▪. Myrie SB, Mymin D, Triggs-Raine B, Jones PJ. Serum lipids, plant sterols, and cholesterol kinetic responses to plant sterol supplementation in phytosterolemia heterozygotes and control individuals. Am J Clin Nutr 2012; 95:837–844. [49]

▪▪. No Authors Given. IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet 2011; 7:e1002260.</source> [22]

Parraga I, Lopez-Torres J, Andres F, Navarro B, et al. Effect of plant sterols on the lipid profile of patients with hypercholesterolaemia. Randomised, experimental study - art. no. 73. BMC Complement Altern Med 2011; 11:12.

▪. Reilly MP, Li M, He J, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 2011; 377:383–392. [23]

Rideout TC, Harding SV, Mackay DS. Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy. Can J Physiol Pharmacol 2012; 90:509–514. PubMed | CrossRef

Rocha M, Banuls C, Bellod L, Jover A, et al. A Review on the Role of Phytosterols: New Insights Into Cardiovascular Risk. Curr Pharm Design 2011; 17:4061–4075.

▪. Schunkert H, König IR, Kathiresan S, et al. Large scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011; 43:333–338. [24]

Weingartner O, Lutjohann D, Vanmierlo T, Muller S, et al. Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus. Chem Phys Lipids 2011; 164:451–456. PubMed | CrossRef

Back to Top | Article Outline
Brain imaging in the context of food perception and eating

Review: (pp. 18–24)

▪. Demos KE, Heatherton TF, Kelley WM. Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior. J Neurosci 2012; 32:5549–5552. [07]

Goto T, Teraminami A, Lee JY, Ohyama K, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J Nutr Biochem 2012; 23:768–776. PubMed | CrossRef

Grimm MOW, Grosgen S, Riemenschneider M, Tanila H, et al. From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry. J Chromatogr A 2011</date>A. 1218:7713-7722.

▪▪. Haahr ME, Rasmussen PM, Madsen K, et al. Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. NeuroImage 2012; 61:884–888. [35]

Le Floc'h N, Otten W, Merlot E. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 2011; 41:1195–1205.

▪. Murdaugh DL, Cox JE, Cook EW, et al. fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. NeuroImage 2012; 59:2709–2721. [44]

▪. Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. Int J Obesity 2012 [Epub ahead of print]. doi:10.1038/ijo.2012.39</source> [42]

Tekabe Y, Luma J, Li Q, Schmidt AM, et al. Imaging of Receptors for Advanced Glycation End Products in Experimental Myocardial Ischemia and Reperfusion Injury. JACC-Cardiovasc Imag 2012; 5:59–67.

▪▪. Volkow ND, Wang GJ, Fowler JS, et al. Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction Inhibitory control. Curr Top Behav Neurosci 2012; 11:1–24. [24]

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Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: review of recent findings

Review: (pp. 25–33)

Avci CB, Yilmaz S, Dogan ZO, Saydam G, et al. Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology 2011; 16:303–307. PubMed

Barcelos GRM, Grotto D, Serpeloni JM, Angeli JPF, et al. Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch Toxicol 2011; 85:1151–1157. PubMed | CrossRef

Bhatia G, Khanna AK, Sonkar R, Mishra SK, et al. Lipid lowering and antioxidant activity of flavones in triton treated hyperlipidemic rats. Med Chem Res 2011; 20:1622–1626. PubMed | CrossRef

Bondonno CP, Yang XB, Croft KD, Considine MJ, et al. Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial. Free Radic Biol Med 2012; 52:95–102. PubMed | CrossRef

Celik H, Kosar M. Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: Structure-activity relationships. Chem-Biol Interact 2012; 197:103–109.

Curtis PJ, Sampson M, Potter J, Dhatariya K, et al. Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes A 1-year, double-blind, randomized, controlled trial. Diabetes Care 2012; 35: 226–232. View Full Text | PubMed | CrossRef

▪. Curtis PJ, Sampson M, Potter J, et al. Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial. Diabetes Care 2012; 35:226–232. [21]

Davis G, Ananga A, Krastanova S, Sutton S, et al. Elevated Gene Expression in Chalcone Synthase Enzyme Suggests an Increased Production of Flavonoids in Skin and Synchronized Red Cell Cultures of North American Native Grape Berries. DNA Cell Biol 2012; 31:939–945. PubMed | CrossRef

dos Santos MCD, Goncalves CFL, Vaisman M, Ferreira ACF, et al. Impact of flavonoids on thyroid function. Food Chem Toxicol 2011; 49:2495–2502. PubMed | CrossRef

Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant Therapy: Current Status and Future Prospects. Curr Med Chem 2011; 18:3871–3888. PubMed | CrossRef

Fraga CG, Oteiza PI. Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med 2011; 51:813–823. PubMed | CrossRef

Friedrich M, Petzke KJ, Raederstorff D, Wolfram S, et al. Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet. Int J Obes 2012; 36:735–743. View Full Text | PubMed | CrossRef

Goto T, Teraminami A, Lee JY, Ohyama K, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J Nutr Biochem 2012; 23:768–776. PubMed | CrossRef

Granado-Serrano AB, Martin MA, Bravo L, Goya L, et al. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem-Biol Interact 2012; 195:154–164. PubMed | CrossRef

Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, et al. Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells. Biochem Biophys Res Commun 2012; 417:169–174. PubMed | CrossRef

Hidalgo M, Oruna-Concha MJ, Kolida S, Walton GE, et al. Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth. J Agric Food Chem 2012; 60:3882–3890. PubMed | CrossRef

Hirawan R, Diehl-Jones W, Beta T. Comparative Evaluation of the Antioxidant Potential of Infant Cereals Produced from Purple Wheat and Red Rice Grains and LC-MS Analysis of Their Anthocyanins. J Agric Food Chem 2011; 59:12330–12341. PubMed | CrossRef

▪▪. Hooper L, Kay C, Abdelhamid A, et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 2012; 95:740–751. [18]

Hwang SL, Shih PH, Yen GC. Neuroprotective Effects of Citrus Flavonoids. J Agric Food Chem 2012; 60:877–885. PubMed | CrossRef

Hyun J, Shin SY, So KM, Lee YH, et al. Isoflavones inhibit the clonogenicity of human colon cancer cells. Bioorg Med Chem Lett 2012; 22:2664–2669. PubMed | CrossRef

Kang SI, Shin HS, Kim HM, Hong YS, et al. Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by beta-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice. Biol Pharm Bull 2012; 35:223–230. PubMed | CrossRef

Kesse-Guyot E, Fezeu L, Andreeva VA, Touvier M, et al. Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later. J Nutr 2012; 142:76–83. PubMed | CrossRef

Kosmala M, Kolodziejczyk K, Zdunczyk Z, Juskiewicz J, et al. Chemical Composition of Natural and Polyphenol-free Apple Pomace and the Effect of This Dietary Ingredient on Intestinal Fermentation and Serum Lipid Parameters in Rats. J Agric Food Chem 2011; 59:9177–9185. PubMed | CrossRef

Kurzawa-Zegota M, Najafzadeh M, Baumgartner A, Anderson D. The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food Chem Toxicol 2012; 50:124–129. PubMed | CrossRef

Lee J, Mitchell AE. Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans. J Agric Food Chem 2012; 60:3874–3881. PubMed | CrossRef

Li FJ, Ye L, Lin SM, Leung LK. Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7. Mol Cell Endocrinol 2011; 344:51–58. PubMed | CrossRef

Li X, Thwe AA, Park NI, Suzuki T, et al. Accumulation of Phenylpropanoids and Correlated Gene Expression during the Development of Tartary Buckwheat Sprouts. J Agric Food Chem 2012; 60:5629–5635. PubMed | CrossRef

Lin YS, Tsai PH, Kandaswami CC, Cheng CH, et al. Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells. Cancer Sci 2011; 102:1829–1839. View Full Text | PubMed | CrossRef

Liu HY, Gu LW. Phlorotannins from Brown Algae (Fucus vesiculosus) Inhibited the Formation of Advanced Glycation Endproducts by Scavenging Reactive Carbonyls. J Agric Food Chem 2012; 60:1326–1334. PubMed | CrossRef

Liu LH, Xie YX, Song ZQ, Shang SB, et al. Influence of dietary flavonoids on the glycation of plasma proteins. Mol Biosyst 2012; 8:2183–2187. PubMed

Lu Q, Jiang JG. Chemical Metabolism of Medicinal Compounds from Natural Botanicals. Curr Med Chem 2012; 19: 1682–1705. PubMed | CrossRef

Malireddy S, Kotha SR, Secor JD, Gurney TO, et al. Phytochemical Antioxidants Modulate Mammalian Cellular Epigenome: Implications in Health and Disease. Antioxid Redox Signal 2012; 17:327–339. PubMed | CrossRef

Matthies A, Loh G, Blaut M, Braune A. Daidzein and Genistein Are Converted to Equol and 5-Hydroxy-Equol by Human Intestinal Slackia isoflavoniconvertens in Gnotobiotic Rats. J Nutr 2012; 142:40–46. PubMed | CrossRef

McAnulty SR, Nieman DC, McAnulty LS, Lynch WS, et al. Effect of Mixed Flavonoids, n-3 Fatty Acids, and Vitamin C on Oxidative Stress and Antioxidant Capacity Before and After Intense Cycling. Int J Sport Nutr Exerc Metab 2011; 21:328–337. PubMed

McCullough ML, Peterson JJ, Patel R, Jacques PF, et al. Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 2012; 95:454–464. PubMed | CrossRef

Michaud-Levesque J, Bousquet-Gagnon N, Beliveau R. Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Exp Cell Res 2012; 318:925–935.

▪. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011; 93:73–80. [17]

Mukai R, Kawabata K, Otsuka S, Ishisaka A, et al. Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells. Free Radic Res 2012; 46:1019–1028. PubMed | CrossRef

Mullen W, Gonzalez J, Siwy J, Franke J, et al. A Pilot Study on the Effect of Short-Term Consumption of a Polyphenol Rich Drink on Biomarkers of Coronary Artery Disease Defined by Urinary Proteomics. J Agric Food Chem 2011; 59:12850–12857. PubMed | CrossRef

Munoz C, Sanchez-Sevilla JF, Botella MA, Hoffmann T, et al. Polyphenol Composition in the Ripe Fruits of Fragaria Species and Transcriptional Analyses of Key Genes in the Pathway. J Agric Food Chem 2011; 59:12598–12604. PubMed | CrossRef

Murphy MM, Barraj LM, Herman D, Bi XY, et al. Phytonutrient Intake by Adults in the United States in Relation to Fruit and Vegetable Consumption. J Acad Nutr Diet 2012; 112:222–229.

Noda S, Tanabe S, Suzuki T. Differential Effects of Flavonoids on Barrier Integrity in Human Intestinal Caco-2 Cells. J Agric Food Chem 2012; 60:4628–4633. PubMed | CrossRef

Ottaviani JI, Kwik-Uribe C, Keen CL, Schroeter H. Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. Am J Clin Nutr 2012; 95:851–858. PubMed | CrossRef

▪. Pérez-Jiménez J, Fezeu L, Touvier M, et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 2011; 93:1220–1228. [08]

Padma VV, Baskaran R, Roopesh RS, Poornima P. Quercetin attenuates lindane induced oxidative stress in wistar rats. Mol Biol Rep 2012; 39:6895–6905. PubMed | CrossRef

Paixao J, Dinis TCP, Almeida LM. Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. Apoptosis 2011; 16:976–989. PubMed | CrossRef

Papotti G, Bertelli D, Bortolotti L, Plessi M. Chemical and Functional Characterization of Italian Propolis Obtained by Different Harvesting Methods. J Agric Food Chem 2012; 60:2852–2862. PubMed | CrossRef

Park HY, Kim GY, Hyun JW, Hwang HJ, et al. 7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-kappa B and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells. Int J Mol Med 2012; 29:1146–1152. PubMed

Poulaert M, Borel P, Caporiccio B, Gunata Z, et al. Grapefruit Juices Impair the Bioaccessibility of beta-Carotene from Orange-Fleshed Sweet Potato but Not Its Intestinal Uptake by Caco-2 Cells. J Agric Food Chem 2012; 60:685–691. PubMed | CrossRef

Priyadarsini RV, Nagini S. Quercetin suppresses cytochrome P450 mediated ROS generation and NF kappa B activation to inhibit the development of 7,12-dimethylbenz. Free Radic Res 2012; 46:41–49. PubMed | CrossRef

Redondo A, Estrella N, Lorenzo AG, Cruzado M, et al. Quercetin and catechin synergistically inhibit angiotensin II-induced redox-dependent signalling pathways in vascular smooth muscle cells from hypertensive rats. Free Radic Res 2012; 46:619–627. PubMed | CrossRef

Riihinen KR, Godecke T, Pauli GF. Purification of berry flavonol glycosides by long-bed gel permeation chromatography. Journal of Chromatography A 2012; 1244:29.

Rossi M, Lugo A, Lagiou P, Zucchetto A, et al. Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy. Ann Oncol 2012; 23:1488–1493. View Full Text | PubMed | CrossRef

Russo M, Spagnuolo C, Tedesco I, Bilotto S, et al. The flavonoid quercetin in disease prevention and therapy: Facts and fancies. Biochem Pharmacol 2012; 83:6–15. View Full Text | PubMed | CrossRef

Shrime MG, Bauer SR, McDonald AC, Chowdhury NH, et al. Flavonoid-Rich Cocoa Consumption Affects Multiple Cardiovascular Risk Factors in a Meta-Analysis of Short-Term Studies. J Nutr 2011; 141:1982–1988. PubMed | CrossRef

Speciale A, Chirafisi J, Saija A, Cimino F. Nutritional Antioxidants and Adaptive Cell Responses: An Update. Curr Mol Med 2011; 11:770–789. PubMed | CrossRef

Spilsbury A, Vauzour D, Spencer JPE, Rattray M. Regulation of NF-kappa B activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. Biochem Biophys Res Commun 2012; 418:578–583. PubMed | CrossRef

Szliszka E, Helewski KJ, Mizgala E, Krol W. The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells. Int J Oncol 2011; 39:771–779. PubMed

Tada N, Maruyama C, Koba S, Tanaka H, et al. Japanese Dietary Lifestyle and Cardiovascular Disease. J Atheroscler Thromb 2011; 18:723–734. PubMed | CrossRef

Tang L, Feng Q, Zhao J, Dong LN, et al. Involvement of UDP-glucuronosyltranferases and sulfotransferases in the liver and intestinal first-pass metabolism of seven flavones in C57 mice and humans in vitro. Food Chem Toxicol 2012; 50:1460–1467. PubMed | CrossRef

Vasanthi HR, ShriShri Mal N, Das DK. Phytochemicals from Plants to Combat Cardiovascular Disease. Curr Med Chem 2012; 19:2242–2251. PubMed

▪. Wallace TC. Anthocyanins in cardiovascular disease. Adv Nutr 2011; 2:1–7. [50]

Wang HK, Yeh CH, Iwamoto T, Satsu H, et al. Dietary Flavonoid Naringenin Induces Regulatory T Cells via an Aryl Hydrocarbon Receptor Mediated Pathway. J Agric Food Chem 2012; 60:2171–2178. PubMed | CrossRef

▪. Wedick NM, Pan A, Cassidy A, et al. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 2012; 95:925–933. [10]

Wedick NM, Pan A, Cassidy A, Rimm EB, et al. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 2012; 95:925–933.

Weng CJ, Yen GC. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev 2012; 38:76–87. PubMed | CrossRef

Xiao JB, Zhao YR, Wang H, Yuan YM, et al. Noncovalent Interaction of Dietary Polyphenols with Common Human Plasma Proteins. J Agric Food Chem 2011; 59:10747–10754. PubMed | CrossRef

Xie F, Lang QY, Zhou M, Zhang HX, et al. The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells. Eur J Pharm Sci 2012; 46:388–396. View Full Text | PubMed | CrossRef

Xin JP, Feinstein DL, Hejna MJ, Lorens SA, et al. Beneficial Effects of Blueberries in Experimental Autoimmune Encephalomyelitis. J Agric Food Chem 2012; 60: 5743–5748. PubMed | CrossRef

Xu YP, Simon JE, Welch C, Wightman JD, et al. Survey of Polyphenol Constituents in Grapes and Grape- Derived Products. J Agric Food Chem 2011; 59: 10586–10593. PubMed | CrossRef

Yang PM, Tseng HH, Peng CW, Chen WS, et al. Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy. Int J Oncol 2012; 40:469–478. PubMed

Yang YC, Lii CK, Lin AH, Yeh YW, et al. Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. Free Radic Biol Med 2011; 51:2073–2081. PubMed | CrossRef

Yde CC, Westerhuis JA, Bertram HC, Knudsen KEB. Application of NMR-based metabonomics suggests a relationship between betaine absorption and elevated creatine plasma concentrations in catheterised sows. Br J Nutr 2012; 107:1603–1615. PubMed | CrossRef

Zamora-Ros R, Knaze V, Lujan-Barroso L, Slimani N, et al. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort. Br J Nutr 2011; 106:1915–1925.

Zamora-Ros R, Knaze V, Lujan-Barroso L, Slimani N, et al. Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr 2011; 106:1090–1099.

Zamora-Ros R, Rabassa M, Llorach R, Gonzalez CA, et al. Application of Dietary Phenolic Biomarkers in Epidemiology: Past, Present, and Future. J Agric Food Chem 2012; 60:6648–6657. PubMed | CrossRef

▪. Zheng XX, Xu YL, Li SH, et al. Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials. Am J Clin Nutr 2011; 94:601–610. [22]

▪. Zhu Y, Ling W, Guo H, et al. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metab Cardiovasc Dis 2012 [Epub ahead of print].</source> [16]

Zuk M, Prescha A, Stryczewska M, Szopa J. Engineering Flax Plants To Increase Their Antioxidant Capacity and Improve Oil Composition and Stability. J Agric Food Chem 2012; 60:5003–5012. PubMed | CrossRef

Back to Top | Article Outline
Citrus flavonoids and lipid metabolism

Review: (pp. 34–40)

Avci CB, Yilmaz S, Dogan ZO, Saydam G, et al. Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology 2011; 16:303–307. PubMed

Barcelos GRM, Grotto D, Serpeloni JM, Angeli JPF, et al. Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch Toxicol 2011; 85:1151–1157. PubMed | CrossRef

Bondonno CP, Yang XB, Croft KD, Considine MJ, et al. Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial. Free Radic Biol Med 2012; 52:95–102. PubMed | CrossRef

Cashman KD, Kiely M. Towards prevention of vitamin D deficiency and beyond: knowledge gaps and research needs in vitamin D nutrition and public health. Br J Nutr 2011; 106:1617–1627. PubMed | CrossRef

▪. Cassidy A, Rimm EB, O'Reilly EJ, et al. Dietary flavonoids and risk of stroke in women. Stroke 2012; 43:946–951. [12]

Celik H, Kosar M. Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: Structure-activity relationships. Chem-Biol Interact 2012; 197:103–109.

▪. Chanet A, Milenkovic D, Deval C, et al. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. J Nutr Biochem 2012; 23:469–477. [51]

Curtis PJ, Sampson M, Potter J, Dhatariya K, et al. Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes A 1-year, double-blind, randomized, controlled trial. Diabetes Care 2012; 35:226–232. View Full Text | PubMed | CrossRef

Davis G, Ananga A, Krastanova S, Sutton S, et al. Elevated Gene Expression in Chalcone Synthase Enzyme Suggests an Increased Production of Flavonoids in Skin and Synchronized Red Cell Cultures of North American Native Grape Berries. DNA Cell Biol 2012; 31:939–945. PubMed | CrossRef

dos Santos MCD, Goncalves CFL, Vaisman M, Ferreira ACF, et al. Impact of flavonoids on thyroid function. Food Chem Toxicol 2011; 49:2495–2502. PubMed | CrossRef

Egert S, Wolffram S, Schulze B, Langguth P, et al. Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. Br J Nutr 2012; 107:539–546. PubMed | CrossRef

Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant Therapy: Current Status and Future Prospects. Curr Med Chem 2011; 18:3871–3888. PubMed | CrossRef

Fraga CG, Oteiza PI. Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med 2011; 51:813–823. PubMed | CrossRef

Friedrich M, Petzke KJ, Raederstorff D, Wolfram S, et al. Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet. Int J Obes 2012; 36:735–743. View Full Text | PubMed | CrossRef

Goto T, Teraminami A, Lee JY, Ohyama K, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J Nutr Biochem 2012; 23:768–776. PubMed | CrossRef

Granado-Serrano AB, Martin MA, Bravo L, Goya L, et al. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem-Biol Interact 2012; 195:154–164. PubMed | CrossRef

Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, et al. Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells. Biochem Biophys Res Commun 2012; 417:169–174. PubMed | CrossRef

Hidalgo M, Oruna-Concha MJ, Kolida S, Walton GE, et al. Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth. J Agric Food Chem 2012; 60:3882–3890. PubMed | CrossRef

Hirawan R, Diehl-Jones W, Beta T. Comparative Evaluation of the Antioxidant Potential of Infant Cereals Produced from Purple Wheat and Red Rice Grains and LC-MS Analysis of Their Anthocyanins. J Agric Food Chem 2011; 59:12330–12341. PubMed | CrossRef

Hwang SL, Shih PH, Yen GC. Neuroprotective Effects of Citrus Flavonoids. J Agric Food Chem 2012; 60:877–885. PubMed | CrossRef

Hyun J, Shin SY, So KM, Lee YH, et al. Isoflavones inhibit the clonogenicity of human colon cancer cells. Bioorg Med Chem Lett 2012; 22:2664–2669. PubMed | CrossRef

Kang SI, Shin HS, Kim HM, Hong YS, et al. Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by beta-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice. Biol Pharm Bull 2012; 35:223–230. PubMed | CrossRef

Kesse-Guyot E, Fezeu L, Andreeva VA, Touvier M, et al. Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later. J Nutr 2012; 142:76–83. PubMed | CrossRef

Kosmala M, Kolodziejczyk K, Zdunczyk Z, Juskiewicz J, et al. Chemical Composition of Natural and Polyphenol-free Apple Pomace and the Effect of This Dietary Ingredient on Intestinal Fermentation and Serum Lipid Parameters in Rats. J Agric Food Chem 2011; 59:9177–9185. PubMed | CrossRef

Kurzawa-Zegota M, Najafzadeh M, Baumgartner A, Anderson D. The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food Chem Toxicol 2012; 50:124–129. PubMed | CrossRef

Lee J, Mitchell AE. Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans. J Agric Food Chem 2012; 60:3874–3881. PubMed | CrossRef

Li FJ, Ye L, Lin SM, Leung LK. Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7. Mol Cell Endocrinol 2011; 344:51–58. PubMed | CrossRef

Li X, Thwe AA, Park NI, Suzuki T, et al. Accumulation of Phenylpropanoids and Correlated Gene Expression during the Development of Tartary Buckwheat Sprouts. J Agric Food Chem 2012; 60:5629–5635. PubMed | CrossRef

Lin YS, Tsai PH, Kandaswami CC, Cheng CH, et al. Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells. Cancer Sci 2011; 102:1829–1839. View Full Text | PubMed | CrossRef

Liu HY, Gu LW. Phlorotannins from Brown Algae (Fucus vesiculosus) Inhibited the Formation of Advanced Glycation Endproducts by Scavenging Reactive Carbonyls. J Agric Food Chem 2012; 60:1326–1334. PubMed | CrossRef

Liu LH, Xie YX, Song ZQ, Shang SB, et al. Influence of dietary flavonoids on the glycation of plasma proteins. Mol Biosyst 2012; 8:2183–2187. PubMed

Lu Q, Jiang JG. Chemical Metabolism of Medicinal Compounds from Natural Botanicals. Curr Med Chem 2012; 19:1682–1705. PubMed | CrossRef

Malireddy S, Kotha SR, Secor JD, Gurney TO, et al. Phytochemical Antioxidants Modulate Mammalian Cellular Epigenome: Implications in Health and Disease. Antioxid Redox Signal 2012; 17:327–339. PubMed | CrossRef

Matthies A, Loh G, Blaut M, Braune A. Daidzein and Genistein Are Converted to Equol and 5-Hydroxy-Equol by Human Intestinal Slackia isoflavoniconvertens in Gnotobiotic Rats. J Nutr 2012; 142:40–46. PubMed | CrossRef

McAnulty SR, Nieman DC, McAnulty LS, Lynch WS, et al. Effect of Mixed Flavonoids, n-3 Fatty Acids, and Vitamin C on Oxidative Stress and Antioxidant Capacity Before and After Intense Cycling. Int J Sport Nutr Exerc Metab 2011; 21:328–337. PubMed

Michaud-Levesque J, Bousquet-Gagnon N, Beliveau R. Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Exp Cell Res 2012; 318:925–935.

Mukai R, Kawabata K, Otsuka S, Ishisaka A, et al. Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells. Free Radic Res 2012; 46:1019–1028. PubMed | CrossRef

Mullen W, Gonzalez J, Siwy J, Franke J, et al. A Pilot Study on the Effect of Short-Term Consumption of a Polyphenol Rich Drink on Biomarkers of Coronary Artery Disease Defined by Urinary Proteomics. J Agric Food Chem 2011; 59:12850–12857. PubMed | CrossRef

▪▪. Mulvihill EE, Assini JM, Lee JK, et al. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes 2011; 60:1446–1457. [27]

▪. Mulvihill EE, Assini JM, Sutherland BG, et al. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol 2010; 30:742–748. [50]

Munoz C, Sanchez-Sevilla JF, Botella MA, Hoffmann T, et al. Polyphenol Composition in the Ripe Fruits of Fragaria Species and Transcriptional Analyses of Key Genes in the Pathway. J Agric Food Chem 2011; 59:12598–12604. PubMed | CrossRef

Murphy MM, Barraj LM, Herman D, Bi XY, et al. Phytonutrient Intake by Adults in the United States in Relation to Fruit and Vegetable Consumption. J Acad Nutr Diet 2012; 112:222–229.

Noda S, Tanabe S, Suzuki T. Differential Effects of Flavonoids on Barrier Integrity in Human Intestinal Caco-2 Cells. J Agric Food Chem 2012; 60:4628–4633. PubMed | CrossRef

Padma VV, Baskaran R, Roopesh RS, Poornima P. Quercetin attenuates lindane induced oxidative stress in wistar rats. Mol Biol Rep 2012; 39:6895–6905. PubMed | CrossRef

Paixao J, Dinis TCP, Almeida LM. Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. Apoptosis 2011; 16:976–989. PubMed | CrossRef

Papotti G, Bertelli D, Bortolotti L, Plessi M. Chemical and Functional Characterization of Italian Propolis Obtained by Different Harvesting Methods. J Agric Food Chem 2012; 60:2852–2862. PubMed | CrossRef

Park HY, Kim GY, Hyun JW, Hwang HJ, et al. 7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-kappa B and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells. Int J Mol Med 2012; 29:1146–1152. PubMed

Poulaert M, Borel P, Caporiccio B, Gunata Z, et al. Grapefruit Juices Impair the Bioaccessibility of beta-Carotene from Orange-Fleshed Sweet Potato but Not Its Intestinal Uptake by Caco-2 Cells. J Agric Food Chem 2012; 60:685–691. PubMed | CrossRef

Priyadarsini RV, Nagini S. Quercetin suppresses cytochrome P450 mediated ROS generation and NF kappa B activation to inhibit the development of 7,12-dimethylbenz. Free Radic Res 2012; 46:41–49. PubMed | CrossRef

Raposeiras-Roubin S, Barreiro-Pardal C, Alvarez E, Juanatey JRG. Is Glycated Hemoglobin an Accurate Enough Predictor of Subclinical Myocardial Injury or a Simple Precursor of Advanced Glycation End Products? J Am Coll Cardiol 2012; 60:166–167.

Redondo A, Estrella N, Lorenzo AG, Cruzado M, et al. Quercetin and catechin synergistically inhibit angiotensin II-induced redox-dependent signalling pathways in vascular smooth muscle cells from hypertensive rats. Free Radic Res 2012; 46:619–627. PubMed | CrossRef

Riihinen KR, Godecke T, Pauli GF. Purification of berry flavonol glycosides by long-bed gel permeation chromatography. Journal of Chromatography A 2012</date>1244:29.

▪. Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab 2011; 96:E782–E792. [42]

Rossi M, Lugo A, Lagiou P, Zucchetto A, et al. Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy. Ann Oncol 2012; 23:1488–1493. View Full Text | PubMed | CrossRef

Russo M, Spagnuolo C, Tedesco I, Bilotto S, et al. The flavonoid quercetin in disease prevention and therapy: Facts and fancies. Biochem Pharmacol 2012; 83:6–15. View Full Text | PubMed | CrossRef

Shrime MG, Bauer SR, McDonald AC, Chowdhury NH, et al. Flavonoid-Rich Cocoa Consumption Affects Multiple Cardiovascular Risk Factors in a Meta-Analysis of Short-Term Studies. J Nutr 2011; 141:1982–1988. PubMed | CrossRef

Speciale A, Chirafisi J, Saija A, Cimino F. Nutritional Antioxidants and Adaptive Cell Responses: An Update. Curr Mol Med 2011; 11:770–789. PubMed | CrossRef

Spilsbury A, Vauzour D, Spencer JPE, Rattray M. Regulation of NF-kappa B activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. Biochem Biophys Res Commun 2012; 418:578–583. PubMed | CrossRef

Szliszka E, Helewski KJ, Mizgala E, Krol W. The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells. Int J Oncol 2011; 39:771–779. PubMed

Tada N, Maruyama C, Koba S, Tanaka H, et al. Japanese Dietary Lifestyle and Cardiovascular Disease. J Atheroscler Thromb 2011; 18:723–734. PubMed | CrossRef

Tang L, Feng Q, Zhao J, Dong LN, et al. Involvement of UDP-glucuronosyltranferases and sulfotransferases in the liver and intestinal first-pass metabolism of seven flavones in C57 mice and humans in vitro. Food Chem Toxicol 2012; 50:1460–1467. PubMed | CrossRef

▪. Tsai SJ, Huang CS, Mong MC, et al. Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice. J Agric Food Chem 2012; 60:514–521. [47]

Vasanthi HR, ShriShri Mal N, Das DK. Phytochemicals from Plants to Combat Cardiovascular Disease. Curr Med Chem 2012; 19:2242–2251. PubMed

Wang HK, Yeh CH, Iwamoto T, Satsu H, et al. Dietary Flavonoid Naringenin Induces Regulatory T Cells via an Aryl Hydrocarbon Receptor Mediated Pathway. J Agric Food Chem 2012; 60:2171–2178. PubMed | CrossRef

Weng CJ, Yen GC. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev 2012; 38:76–87. PubMed | CrossRef

Xiao JB, Zhao YR, Wang H, Yuan YM, et al. Noncovalent Interaction of Dietary Polyphenols with Common Human Plasma Proteins. J Agric Food Chem 2011; 59:10747–10754. PubMed | CrossRef

Xie F, Lang QY, Zhou M, Zhang HX, et al. The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells. Eur J Pharm Sci 2012; 46:388–396. View Full Text | PubMed | CrossRef

Xin JP, Feinstein DL, Hejna MJ, Lorens SA, et al. Beneficial Effects of Blueberries in Experimental Autoimmune Encephalomyelitis. J Agric Food Chem 2012; 60:5743–5748. PubMed | CrossRef

Xu YP, Simon JE, Welch C, Wightman JD, et al. Survey of Polyphenol Constituents in Grapes and Grape-Derived Products. J Agric Food Chem 2011; 59:10586–10593. PubMed | CrossRef

Yang PM, Tseng HH, Peng CW, Chen WS, et al. Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy. Int J Oncol 2012; 40:469–478. PubMed

Yang YC, Lii CK, Lin AH, Yeh YW, et al. Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. Free Radic Biol Med 2011; 51:2073–2081. PubMed | CrossRef

Zamora-Ros R, Knaze V, Lujan-Barroso L, Slimani N, et al. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort. Br J Nutr 2011; 106:1915–1925.

Zamora-Ros R, Knaze V, Lujan-Barroso L, Slimani N, et al. Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr 2011; 106:1090–1099.

Zamora-Ros R, Rabassa M, Llorach R, Gonzalez CA, et al. Application of Dietary Phenolic Biomarkers in Epidemiology: Past, Present, and Future. J Agric Food Chem 2012; 60:6648–6657. PubMed | CrossRef

Zuk M, Prescha A, Stryczewska M, Szopa J. Engineering Flax Plants To Increase Their Antioxidant Capacity and Improve Oil Composition and Stability. J Agric Food Chem 2012; 60:5003–5012. PubMed | CrossRef

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Dietary fats and other nutrients on stroke

Review: (pp. 41–48)

Alexandre-Gouabau MCF, Bailly E, Moyon TL, Grit IC, et al. Postnatal growth velocity modulates alterations of proteins involved in metabolism and neuronal plasticity in neonatal hypothalamus in rats born with intrauterine growth restriction. J Nutr Biochem 2012; 23:140–152. PubMed | CrossRef

Barella LF, de Oliveira JC, Branco RCS, Camargo RL, et al. Early Exposure to a High-Fat Diet has more Drastic Consequences on Metabolism Compared with Exposure During Adulthood in Rats. Horm Metab Res 2012; 44:458–464. PubMed | CrossRef

▪. Bin Q, Hu X, Cao Y, Gao F. The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials. Thromb Haemost 2011; 105:579–585. [45]

▪. Bolland MJ, Grey A, Avenell A, et al. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 2011; 342: d2040. [75]

Davis HR, Tershakovec AM, Tomassini JE, Musliner T. Intestinal sterol transporters and cholesterol absorption inhibition. Curr Opin Lipidology 2011; 22:467–478.

de Mello VDF, Schwab U, Kolehmainen M, Koenig W, et al. A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study. Diabetologia 2011; 54:2755–2767. View Full Text | PubMed | CrossRef

▪▪. Goldstein LB, Bushnell CD, Adams RJ, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011; 42:517–584. [02]

▪▪. Hooper L, Summerbell CD, Thompson R, et al. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database Syst Rev 2012; 5:CD002137.</source> [05]

Kalish BT, Fallon EM, Puder M. A Tutorial on Fatty Acid Biology. J Parenter Enter Nutr 2012; 36:380–388. PubMed | CrossRef

Landberg R, Naidoo N, van Dam RM. Diet and endothelial function: from individual components to dietary patterns. Curr Opin Lipidology 2012; 23:147–155.

▪. Larsson SC, Orsini N, Wolk A. Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. Am J Clin Nutr 2012; 95:362–366. [58]

▪. Larsson SC, Orsini N, Wolk A. Dietary potassium intake and risk of stroke: a dose-response meta-analysis of prospective studies. Stroke 2011; 42:2746–2750. [61]

Levy E, Harmel E, Laville M, Sanchez R, et al. Expression of Sar1b Enhances Chylomicron Assembly and Key Components of the Coat Protein Complex II System Driving Vesicle Budding. Arterioscler Thromb Vasc Biol 2011; 31:2692.

Lourenco AP, Vasques-Novoa F, Fontoura D, Bras-Silva C, et al. A Western-Type Diet Attenuates Pulmonary Hypertension with Heart Failure and Cardiac Cachexia in Rats. J Nutr 2011; 141:1954–1960. PubMed | CrossRef

MacKay D, Jones PJH. Evaluation of methods for the determination of cholesterol absorption and synthesis in humans. Atherosclerosis 2011; 218:253–262. PubMed | CrossRef

MacKay DS, Jones PJH. Plasma noncholesterol sterols: current uses, potential and need for standardization. Curr Opin Lipidology 2012; 23:241–247.

McAnulty SR, Nieman DC, McAnulty LS, Lynch WS, et al. Effect of Mixed Flavonoids, n-3 Fatty Acids, and Vitamin C on Oxidative Stress and Antioxidant Capacity Before and After Intense Cycling. Int J Sport Nutr Exerc Metab 2011; 21:328–337. PubMed

▪▪. Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 2011; 58:2047–2067. [19]

Mozaffarian D, Wu JHY. Omega-3 Fatty Acids and Cardiovascular Disease Effects on Risk Factors, Molecular Pathways, and Clinical Events. J Am Coll Cardiol 2011; 58:2047–2067. PubMed | CrossRef

Nestel P. Nutrition and metabolism: the changing face of the dairy-cardiovascular risk paradox. Curr Opin Lipidology 2012; 23:1–3.

▪. O'Donnell MJ, Yusuf S, Mente A, et al. Urinary sodium and potassium excretion and risk of cardiovascular events. JAMA 2011; 306:2229–2238. [62]

Sfar S, El Heni J, Laporte F, Braham H, et al. Trace element status and fatty acids metabolism during healthy ageing: An example of a population from the Tunisian eastern coast. Exp Gerontol 2012; 47:243–249. View Full Text | PubMed | CrossRef

Sorrentino V, Zelcer N. Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor. Curr Opin Lipidology 2012; 23:213–219.

▪. Sun Q, Pan A, Hu FB, et al. 25-Hydroxyvitamin D Levels and the Risk of Stroke: a prospective study and meta-analysis. Stroke 2012; 43:1470–1477. [53]

▪. Susic D, Frohlich ED. Salt consumption and cardiovascular, renal, and hypertensive diseases: clinical and mechanistic aspects. Curr Opin Lipidol 2012; 23:11–16. [76]

Tada N, Maruyama C, Koba S, Tanaka H, et al. Japanese Dietary Lifestyle and Cardiovascular Disease. J Atheroscler Thromb 2011; 18:723–734. PubMed | CrossRef

Tardif N, Salles J, Landrier JF, Mothe-Satney I, et al. Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats. Clin Nutr 2011; 30:799–806. PubMed | CrossRef

Tekabe Y, Luma J, Li Q, Schmidt AM, et al. Imaging of Receptors for Advanced Glycation End Products in Experimental Myocardial Ischemia and Reperfusion Injury. JACC-Cardiovasc Imag 2012; 5:59–67.

Thomas T, Pfeiffer AFH. Foods for the prevention of diabetes: how do they work? Diabetes-Metab Res Rev 2012; 28:25–49.

Tokede OA, Gaziano JM, Djousse L. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr 2011; 65:879–886. View Full Text | PubMed | CrossRef

Tovar AR, Diaz-Villasenor A, Cruz-Salazar N, Ordaz G, et al. Dietary Type and Amount of Fat Modulate Lipid Metabolism Gene Expression in Liver and in Adipose Tissue in High-fat Diet-fed Rats. Arch Med Res 2011; 42:540–553. PubMed | CrossRef

▪. Van der Schueren BJ, Verstuyf A, Mathieu C. Straight from D-Heart: vitamin D status and cardiovascular disease. Curr Opin Lipidol 2012; 23:17–23. [52]

▪. Wang L, Manson JE, Sesso HD. Calcium intake and risk of cardiovascular disease: a review of prospective studies and randomized clinical trials. Am J Cardiovasc Drugs 2012; 12:105–116. [63]

Weingartner O, Lutjohann D, Vanmierlo T, Muller S, et al. Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus. Chem Phys Lipids 2011; 164:451–456. PubMed | CrossRef

▪▪. Willett WC. Dietary fats and coronary heart disease. J Intern Med 2012; 272:13–24. [04]

Xu ZW, Li YS, Wang J, Wu B, et al. Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition-associated liver disease in adults. Clin Nutr 2012; 31:217–223. PubMed | CrossRef

Yoshikawa T, Hiki N, Taguri M, Sano T, et al. A Phase III Trial to Evaluate the Effect of Perioperative Nutrition Enriched with Eicosapentaenoic Acid on Body Weight Loss after Total Gastrectomy for T2T4a Gastric Cancer. Jpn J Clin Oncol 2012; 42:459–462. View Full Text | PubMed | CrossRef

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What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?

Review: (pp. 49–56)

Belalcazar LM, Ballantyne CM. Nutrition and metabolism - sphingolipids and branched chain amino acids: indicators and effectors of adipose tissue function and diabetes risk. Curr Opin Lipidology 2011; 22:503–504. View Full Text | PubMed | CrossRef

▪. Chalkiadaki A, Guarente L. High fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 2012; 16:180–188.</source> [42]

▪. Gauthier MS, O'Brien EL, Bigornia S, et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun 2011; 404:382–387. [09]

▪. Gillum MP, Kotas ME, Erion DM, et al. SirT1 regulates adipose tissue inflammation. Diabetes 2011; 60:3235–3245. [14]

▪. Goossens GH, Bizzarri A, Venteclef N, et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 2011; 124:67–76. [13]

▪. Hardy OT, Perugini RA, Nicoloro SM, et al. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis 2011; 7:60–67. [10]

He J, Chen DW, Zhang KY, Yu B. A high-amylopectin diet caused hepatic steatosis associated with more lipogenic enzymes and increased serum insulin concentration. Br J Nutr 2011; 106:1470–1475. PubMed | CrossRef

▪▪. Klöting N, Fasshauer M, Dietrich A, et al. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 2010; 299:E506–E515. [08]

Lugli AK, Donatelli F, Schricker T, Kindler CH, et al. Parenteral amino acids v. dextrose infusion: an anabolic strategy to minimise the catabolic response to surgery while maintaining normoglycaemia in diabetes mellitus type 2 patients. Br J Nutr 2012; 107:573–580. PubMed | CrossRef

▪. Ruderman NB, Xu XJ, Nelson L, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab 2010; 298:E751–E760. [01]

▪. Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med 2011; 89:667–676. [38]

▪. Samocha-Bonet D, Chisholm DJ, Tonks K, et al. Insulin-sensitive obesity in humans – a ‘favorable fat’ phenotype? Trends Endocrinol Metab 2012; 23:116–124. [03]

▪▪. Sjöström L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA 2012; 307:56–65. [07]

▪. Vandanmagsar B, Youm YH, Ravussin A, et al. The NALP3/NLRP3 inflammasome instigates obesity-induced autoinflammation and insulin resistance. Nat Med 2011; 17:179–188. [31]

▪▪. Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 2011; 12:408–415. [32]

▪▪. Xu XJ, Gauthier MS, Hess DT, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res 2012; 53:792–801. [12]

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Main findings from the prospective Cardiovascular Risk in Young Finns Study

Review: (pp. 57–64)

Chapman KA, Gropman A, MacLeod E, Stagni K, et al. Acute management of propionic acidemia. Mol Genet Metab 2012; 105:16–25. PubMed | CrossRef

▪. Jääskeläinen P, Magnussen CG, Pahkala K, et al. Childhood Nutrition in Predicting Metabolic Syndrome in Adults: The Cardiovascular Risk in Young Finns Study. Diabetes Care 2012; 35:1937–1943.</source> [25]

▪. Juhola J, Oikonen M, Magnussen CG, et al. Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study. Circulation 2012; 126:402–409. [22]

▪. Juonala M, Juhola J, Magnussen CG, et al. Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study. J Clin Endocrinol Metab 2011; 96:E1542–E1549. [21]

▪▪. Juonala M, Magnussen CG, Berenson GS, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 2011; 365:1876–1885. [34]

▪▪. Juonala M, Magnussen CG, Venn A, et al. Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the Cardiovascular Risk in Young Finns Study and the Childhood Determinants of Adult Health (CDAH) Study. Arterioscler Thromb Vasc Biol 2012; 32:1024–1031. [41]

▪. Laitinen TT, Pahkala K, Magnussen CG, et al. Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2012; 125:1971–1978. [40]

Liu LH, Xie YX, Song ZQ, Shang SB, et al. Influence of dietary flavonoids on the glycation of plasma proteins. Mol Biosyst 2012; 8:2183–2187. PubMed

Maher P. Methylglyoxal, advanced glycation end products and autism: Is there a connection? Med Hypotheses 2012; 78:548–552.

Obeid R, Shannan B, Herrmann W. Advanced glycation end products overload might explain intracellular cobalamin deficiency in renal dysfunction, diabetes and aging. Med Hypotheses 2011; 77:884–888. PubMed | CrossRef

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The role of dietary protein in blood pressure regulation

Review: (pp. 65–70)

Airinei G, Gaudichon C, Bos C, Bon C, et al. Postprandial protein metabolism but not a fecal test reveals protein malabsorption in patients with pancreatic exocrine insufficiency. Clin Nutr 2011; 30:831–837. PubMed | CrossRef

Ambuhl PM. Protein Intake in Renal and Hepatic Disease. Int J Vitam Nutr Res 2011; 81:162–172. PubMed | CrossRef

Barbosa AWC, Benevides GP, Alferes LMT, Salomao EM, et al. A leucine-rich diet and exercise affect the biomechanical characteristics of the digital flexor tendon in rats after nutritional recovery. Amino Acids 2012; 42:329–336. PubMed | CrossRef

Bortolotti M, Dubuis J, Schneiter P, Tappy L. Effects of dietary protein on lipid metabolism in high fructose fed humans. Clin Nutr 2012; 31:238–245. PubMed | CrossRef

Boukhettala N, Claeyssens S, Bensifi M, Maurer B, et al. Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in HCT-8 cells: involvement of GCN2 and mTOR pathways. Amino Acids 2012; 42:375–383. PubMed | CrossRef

Cho K, Mabasa L, Bae S, Walters MW, et al. Maternal high-methyl diet suppresses mammary carcinogenesis in female rat offspring. Carcinogenesis 2012; 33:1106–1112. View Full Text | PubMed | CrossRef

Colombani PC, Mettler S. Role of Dietary Proteins in Sports. Int J Vitam Nutr Res 2011; 81:120–124. PubMed | CrossRef

Dai ZL, Li XL, Xi PB, Zhang J, et al. Metabolism of select amino acids in bacteria from the pig small intestine. Amino Acids 2012; 42:1597–1608.

▪. Dong JY, Tong X, Wu ZW, et al. Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr 2011; 106:317–326. [21]

▪▪. Ferreira-Filho SR, de Castro Rodrigues Ferreira AC, de Oliveira PC. Systemic hemodynamic changes in young and elderly normotensive individuals after ingestion of meals with high lipid, protein, and carbohydrate contents. Blood Press Monit 2012; 17:110–115. [44]

▪▪. Friedman AN, Ogden LG, Foster GD, et al. Comparative effects of low-Carbohydrate High-Protein versus low-fat diets on the kidney. Clin J Am Soc Nephrol 2012; 7:1103–1111. [51]

Gamble MV, Hall MN. Relationship of Creatinine and Nutrition with Arsenic Metabolism. Environ Health Perspect 2012; 120:A145–A146. PubMed | CrossRef

Guigoz Y. Dietary Proteins in Humans: Basic Aspects and Consumption in Switzerland. Int J Vitam Nutr Res 2011; 81:87–100. PubMed | CrossRef

▪▪. He J, Wofford MR, Reynolds K, et al. Effect of dietary protein supplementation on blood pressure: a randomized, controlled trial. Circulation 2011; 124:589–595. [08]

Hidalgo M, Oruna-Concha MJ, Kolida S, Walton GE, et al. Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth. J Agric Food Chem 2012; 60:3882–3890. PubMed | CrossRef

▪▪. Hodgson JM, Zhu K, Lewis JR, et al. Long-term effects of a protein-enriched diet on blood pressure in older women. Br J Nutr 2012; 107:1664–1672.</source> [09]

Holecek M, Kovarik M. Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - Effect of starvation. Food Chem Toxicol 2011; 49:3336–3342. PubMed | CrossRef

▪. Jahan-Mihan A, Luhovyy BL, El Khoury D, Anderson GH. Dietary proteins as determinants of metabolic and physiologic functions of the gastrointestinal tract. Nutrients 2011; 3:574–603. [45]

Kalantar-Zadeh K, Burrowes JD, Franch H, Gutekunst LA, et al. Nephrology and Nutrition Leaders Coming to Hawaii for the World Renal Nutrition Week: Why is the 16th Congress in Renal Nutrition and Metabolism in Honolulu, Hawai'i, June 2012, Worth Attending? J Renal Nutr 2012; 22:1–3.

Keller U. Dietary Proteins in Obesity and in Diabetes. Int J Vitam Nutr Res 2011; 81:125–133. PubMed | CrossRef

Kim SJ, Kim DG, Lee MD. Effects of Branched-Chain Amino Acid Infusions on Liver Regeneration and Plasma Amino Acid Patterns in Partially Hepatectomized Rats. Hepato-Gastroenterol 2011; 58:1280–1285.

Lugli AK, Donatelli F, Schricker T, Kindler CH, et al. Parenteral amino acids v. dextrose infusion: an anabolic strategy to minimise the catabolic response to surgery while maintaining normoglycaemia in diabetes mellitus type 2 patients. Br J Nutr 2012; 107:573–580. PubMed | CrossRef

Nasser M, Javaheri H, Fedorowicz Z, Noorani Z. Carnitine supplementation for inborn errors of metabolism - art. no. CD006659. Cochrane Database Syst Rev 2012</date> 6659.

▪▪. Pal S, Ellis V. Acute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal women. Br J Nutr 2011; 105:1512–1519. [42]

Pennings B, Groen B, de Lange A, Gijsen AP, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol-Endocrinol Metab 2012; 302:E992–E999. PubMed | CrossRef

▪. Russell WR, Gratz SW, Duncan SH, et al. High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health. Am J Clin Nutr 2011; 93:1062–1072. [54]

Smith AH, Liaw J, Steinmaus C, Basu A, et al. Relationship of Creatinine and Nutrition with Arsenic Metabolism: Smith, et al. Respond. Environ Health Perspect 2012; 120:A146–A147. PubMed | CrossRef

Smith GI, Villareal DT, Sinacore DR, Shah K, et al. Muscle Protein Synthesis Response to Exercise Training in Obese, Older Men and Women. Med Sci Sports Exerc 2012; 44:1259–1266. View Full Text | PubMed | CrossRef

Stephens FB, Marimuthu K, Cheng Y, Patel N, et al. Vegetarians have a reduced skeletal muscle carnitine transport capacity. Am J Clin Nutr 2011; 94:938–944. PubMed | CrossRef

Ten Have GAM, Engelen M, Soeters PB, Deutz NEP. Absence of post-prandial gut anabolism after intake of a low quality protein meal. Clin Nutr 2012; 31:273–282. PubMed | CrossRef

▪. Teunissen-Beekman KF, Dopheide J, Geleijnse JM, et al. Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure (PROPRES), a randomized trial. Am J Clin Nutr 2012; 95:966–971. [07]

▪. Tuttle KR, Milton JE, Packard DP, et al. Dietary amino acids and blood pressure: a cohort study of patients with cardiovascular disease. Am J Kidney Dis 2012; 59: 803–809. [20]

Tuttle KR, Milton JE, Packard DP, Shuler LA, et al. Dietary Amino Acids and Blood Pressure: A Cohort Study of Patients With Cardiovascular Disease. Am J Kidney Dis 2012; 59:803–809. PubMed | CrossRef

Verbruggen SC, Schierbeek H, Coss-Bu J, Joosten KFM, et al. Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin. Clin Nutr 2011; 30:469–477. PubMed | CrossRef

Wagner JVE, Moe-Byrne T, Grover Z, McGuire W. Glutamine supplementation for young infants with severe gastrointestinal disease - art. no. CD005947. Cochrane Database Syst Rev 2012</date>5947.

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Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans

Review: (pp. 71–77)

Calbet JA, Mooren FC, Burke LM, Stear SJ, et al. A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance: part 24. Br J Sports Med 2011; 45:1005–1007. View Full Text | PubMed | CrossRef

Cashman KD, Kiely M. Towards prevention of vitamin D deficiency and beyond: knowledge gaps and research needs in vitamin D nutrition and public health. Br J Nutr 2011; 106:1617–1627. PubMed | CrossRef

Che LL, Xiao DS, Xu HX, Lu LW. Changes of Iron Stores and Duodenal Transepithelial Iron Transfer During Regular Exercise in Rats. Biol Trace Elem Res 2011; 143: 1044–1053. PubMed | CrossRef

Corbin KD, Zeisel SH. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol 2012; 28:159–165. View Full Text | PubMed | CrossRef

Corkins MR. Copper metabolism and pediatric cholestasis. Curr Opin Clin Nutr Metab Care 2011; 14:642–646. View Full Text | PubMed | CrossRef

Earnest CP, Lupo M, White KM, Church TS. Effect of Astaxanthin on Cycling Time Trial Performance. Int J Sports Med 2011; 32:882–888. PubMed | CrossRef

El Kochairi I, Montagner A, Rando G, Lohmann C, et al. Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice. Cardiovasc Res 2011; 91:732–741. View Full Text | PubMed | CrossRef

Gamble MV, Hall MN. Relationship of Creatinine and Nutrition with Arsenic Metabolism. Environ Health Perspect 2012; 120:A145–A146. PubMed | CrossRef

Ito S, Ishida H, Uenishi K, Murakami K, et al. The relationship between habitual dietary phosphorus and calcium intake, and bone mineral density in young Japanese women: a cross-sectional study. Asia Pac J Clin Nutr 2011; 20:411–417. PubMed

Jimenez-Aliaga K, Bermejo-Bescos P, Benedi J, Martin-Aragon S. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci 2011; 89:939–945. PubMed | CrossRef

Kilding AE, Overton C, Gleave J. Effects of Caffeine, Sodium Bicarbonate, and Their Combined Ingestion on High-Intensity Cycling Performance. Int J Sport Nutr Exerc Metab 2012; 22:175–183. PubMed

Kressler J, Millard-Stafford M, Warren GL. Quercetin and Endurance Exercise Capacity: A Systematic Review and Meta-analysis. Med Sci Sports Exerc 2011; 43:2396–2404. View Full Text | PubMed | CrossRef

Krol E, Krejpcio Z, Chmurzynska A. Folic Acid and Protein Content in Maternal Diet and Postnatal High-Fat Feeding Affect the Tissue Levels of Iron, Zinc, and Copper in the Rat. Biol Trace Elem Res 2011; 144:885–893. PubMed | CrossRef

▪▪. Lee P, Swarbrick MM, Zhao JT, Ho KKY. Inducible brown adipogenesis of supraclavicular fat in adult humans. Endocrinology 2011; 152:3597–3602. [42]

Lin JG, Tang YC, Kong QH, Chen AP. Curcumin eliminates the inhibitory effect of advanced glycation end-products (AGEs) on gene expression of AGE receptor-1 in hepatic stellate cells in vitro. Lab Invest 2012; 92:827–841. PubMed | CrossRef

▪. Ma S, Yu H, Zhao Z, et al. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J Mol Cell Biol 2012; 4:88–96. [47]

Park MY, Ji GE, Sung MK. Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice. Dig Dis Sci 2012; 57:355–363.

Smith AH, Liaw J, Steinmaus C, Basu A, et al. Relationship of Creatinine and Nutrition with Arsenic Metabolism: Smith, et al. Respond. Environ Health Perspect 2012; 120: A146–A147. PubMed | CrossRef

Smith GI, Villareal DT, Sinacore DR, Shah K, et al. Muscle Protein Synthesis Response to Exercise Training in Obese, Older Men and Women. Med Sci Sports Exerc 2012; 44:1259–1266. View Full Text | PubMed | CrossRef

Thibault R, Flet L, Vavasseur F, Lemerle M, et al. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: Results of a prospective, randomized, double-blind, cross-over study. Clin Nutr 2011; 30:807–811. PubMed | CrossRef

Wang J, Pan Y, Hong Y, Zhang QY, et al. Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats - art. no. 548430. Evid-based Complement Altern Med 2012</date>48430.

▪▪. Wu J, Bostrom P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012; 150:1–11. [41]

Yde CC, Westerhuis JA, Bertram HC, Knudsen KEB. Application of NMR-based metabonomics suggests a relationship between betaine absorption and elevated creatine plasma concentrations in catheterised sows. Br J Nutr 2012; 107:1603–1615. PubMed | CrossRef

▪▪. Yoneshiro T, Aita S, Kawai Y, et al. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012; 95:845–850. [33]

Zhuang XY, Pang XF, Zhang W, Wu WB, et al. Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction. Life Sci 2012; 90:131–139. View Full Text | PubMed | CrossRef

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Metabolic endotoxaemia: is it more than just a gut feeling?

Review: (pp. 78–85)

▪▪. Clemente-Postigo M, Queipo-Ortuño MI, Murri M, et al. Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. J Lipid Res 2012; 53:973–978. [45]

▪. Gøbel RJ, Larsen N, Jakobsen M, et al. Probiotics to obese adolescents; RCT examining the effects on inflammation and metabolic syndrome. J Pediatr Gastroenterol Nutr 2012; 55:673–678.</source> [34]

▪▪. Harte AL, Varma MC, Tripathi G, et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care 2012; 35:375–382. [51]

Khan MT, Duncan SH, Stams AJM, van Dijl JM, et al. The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic-anoxic interphases. Isme J 2012; 6:1578–1585. PubMed

▪. Laugerette F, Furet JP, Debard C, et al. Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice. Am J Physiol Endocrinol Metab 2012; 302:E374–E386. [46]

▪. Leber B, Tripolt NJ, Blattl D, et al. The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study. Eur J Clin Nutr 2012; 66:1110–1115.</source> [33]

Murphy MM, Barraj LM, Herman D, Bi XY, et al. Phytonutrient Intake by Adults in the United States in Relation to Fruit and Vegetable Consumption. J Acad Nutr Diet 2012; 112:222–229.

Nasser M, Javaheri H, Fedorowicz Z, Noorani Z. Carnitine supplementation for inborn errors of metabolism - art. no. CD006659. Cochrane Database Syst Rev 2012</date> 6659.

▪▪. Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 2012; 142:1100e2–1101e2. [50]

Smith AR, Macfarlane GT, Reynolds N, O'May GA, et al. Effect of a synbiotic on microbial community structure in a continuous culture model of the gastric microbiota in enteral nutrition patients. FEMS Microbiol Ecol 2012; 80:135–145. PubMed | CrossRef

Trautvetter U, Ditscheid B, Kiehntopf M, Jahreis G. A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans. Clin Nutr 2012; 31:230–237. PubMed | CrossRef

Wagner JVE, Moe-Byrne T, Grover Z, McGuire W. Glutamine supplementation for young infants with severe gastrointestinal disease - art. no. CD005947. Cochrane Database Syst Rev 2012</date>5947.

▪. Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011; 334:105–108. [16]

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Dietary fructose, hyperuricemia and hypertension

Bortolotti M, Dubuis J, Schneiter P, Tappy L. Effects of dietary protein on lipid metabolism in high fructose fed humans. Clin Nutr 2012; 31:238–245. PubMed | CrossRef

Decombaz J, Jentjens R, Ith M, Scheurer E, et al. Fructose and Galactose Enhance Postexercise Human Liver Glycogen Synthesis. Med Sci Sports Exerc 2011; 43:1964–1971. View Full Text | PubMed

Pennings B, Groen B, de Lange A, Gijsen AP, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol-Endocrinol Metab 2012; 302:E992–E999. PubMed | CrossRef

Pollock NK, Bundy V, Kanto W, Davis CL, et al. Greater Fructose Consumption Is Associated with Cardiometabolic Risk Markers and Visceral Adiposity in Adolescents. J Nutr 2012; 142:251–257. PubMed | CrossRef

Soeters PB, Grecu I. Have We Enough Glutamine and How Does It Work? A Clinician's View. Ann Nutr Metab 2012; 60:17–26. View Full Text | PubMed | CrossRef

Zhang ZY, Zeng JJ, Kjaergaard M, Guan N, et al. Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring. Clin Exp Pharmacol Physiol 2011; 38:613–622. View Full Text | PubMed | CrossRef

Zhu YY, Pandya BJ, Choi HK. Comorbidities of Gout and Hyperuricemia in the US General Population: NHANES 2007–2008. Am J Med 2012; 125:679. PubMed | CrossRef

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