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Current Opinion in Lipidology:
doi: 10.1097/MOL.0000000000000044
NUTRITION AND METABOLISM: Edited by Frank M. Sacks and Lawrence J. Appel

Dietary patterns, Mediterranean diet, and cardiovascular disease

Martinez-Gonzalez, Miguel Angela,b; Bes-Rastrollo, Mairaa



In the recent article by Martinez-Gonzalez et al.[1], a number of errors were introduced by the publisher for which we apologise. Please note the following corrections.

Page 23, left column, middle paragraph, the opening line should read: ‘Two Italian rural male cohorts of the Seven Countries Study (n: 1139) [27]’.

Page 23, right column, first paragraph, the opening line should read: ‘The Monitoring Project on Risk Factors and Chronic Diseases in the Netherlands (MORGEN) [29]’.

Page 23, right column, third paragraph, the final line should read: ‘was excluded because it was subsequently updated [22].’

In Figure 2 the second number on the right x axis should be 2.00, the corrected figure is shown below.  

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Current Opinion in Lipidology. 25(4):326, August 2014.

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Purpose of review

The objective of this manuscript was to review the evidence on the association between adherence to a Mediterranean diet (MeDiet) and the risk of cardiovascular disease (CVD). We also updated the results of the last available meta-analysis.

Recent findings

In 2013, a landmark study in the field, the PREvención con DIeta MEDiterránea randomized trial, with 7447 high-risk participants, published its final results. They provided a strong support to the beneficial role of a traditional MeDiet for primary cardiovascular prevention. When these results were combined with those of the Lyon Diet Heart Study (a secondary prevention trial), we found that an intervention with a MeDiet was associated with a 38% relative reduction in the risk of CVD clinical events (pooled random-effects risk ratio: 0.62; 95% confidence interval, CI: 0.45–0.85). Regarding observational studies assessing clinical end-points as outcome, we identified seven new cohort studies published after the last meta-analysis. After removing studies that only assessed fatal outcomes, a two-point increase in adherence to the MeDiet (0–9 score) was associated with a significant reduction in cardiovascular events (pooled risk ratio: 0.87; 95% CI: 0.85–0.90) with no evidence of heterogeneity.


Consistent evidence suggests that the promotion of the Mediterranean dietary pattern is an effective and feasible tool for the prevention of CVD.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins


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