Skip Navigation LinksHome > June 2011 - Volume 22 - Issue 3 > New genes involved in hepatic steatosis
Current Opinion in Lipidology:
doi: 10.1097/MOL.0b013e3283462288
Lipid metabolism: Edited by Jeffrey S. Cohn

New genes involved in hepatic steatosis

Lou-Bonafonte, José Ma; Arnal, Carmenb,d; Osada, Jesúsc,d

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Abstract

Purpose of review: To summarize currently available information about the mechanisms involved in liver fat accumulation.

Recent findings: The contribution of functional genomics approaches, such as those represented by high-throughput analysis and genetically modified mice, may envision a complex network involving fatty acid, triglyceride and phospholipid metabolisms and lipid droplet dynamics. Likewise, it may pose an exquisite regulation exerted through insulin, glucocorticoids, thyroid hormones, transcription factors and microRNAs, orchestrated with sexual differences and able to respond to environmental factors such as nutritional or viral influences among others.

Summary: The information gathered will facilitate further research to complete gaps of interacting pieces among regulators and new contributing agents emerging from high-throughput analyses. With this new paradigm, new biomarkers able to discriminate the progression of hepatic steatosis into human steatohepatitis will eventually emerge, and hopefully new therapeutic approaches will be developed.

© 2011 Lippincott Williams & Wilkins, Inc.

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