Trichomonas vaginalis is emerging as a major pathogen of men and women and is associated with serious health consequences. Advances in diagnosis and treatment are presented. The complexity of trichomonad pathogenesis is illustrated in the interaction of this parasite with human cells, tissues and the immune system. It is now becoming evident that the interaction of trichomonads with the host is frequently modulated by environmental signals. The molecular biology of trichomonads is still in its infancy, but analysis of genes, genomic structure and transcriptional mechanisms suggest that trichomonads combine both prokaryotic and eukaryotic features. Evidence for the ancient divergence of trichomonads from other eukaryotic lineages is discussed.
aDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, and bDepartment of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Correspondence to Michael W. Lehker, PhD, University of Texas at El Paso, 500 W. University Ave, El Paso, TX 79968, USA. Tel: +1 915 747 5138; fax: +1 915 747 5808; e-mail: email@example.com
AbbreviationsSLPI: secretory leukocyte protease inhibitorINR: metazoan initiator element