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18F-Fluorodeoxyglucose positron emission tomography and infectious diseases: current applications and future perspectives

Bassetti, Matteo; Carnelutti, Alessia; Muser, Daniele; Righi, Elda; Petrosillo, Nicola; Di Gregorio, Fernando; Werner, Thomas J.; Alavi, Abass

Current Opinion in Infectious Diseases: April 2017 - Volume 30 - Issue 2 - p 192–200
doi: 10.1097/QCO.0000000000000354

Purpose of review 18F-Fluorodeoxyglucose positron emission tomography/computed tomography is a well-established technique for diagnosis and management of a number of neoplastic conditions. However, in recent years the body of literature regarding its potential role in infectious diseases has progressively increased, with promising results.

Recent findings So far 18F-fluorodeoxyglucose positron emission tomography/computed tomography has a well-established role and is recommended by guidelines only in a few settings, such as prosthetic valve endocarditis, vascular device infections, and chronic osteomyelitis. However, even the lack of large, prospective randomized trials, an increasing number of small series and case reports suggest a potential role in the diagnosis, disease staging, and monitoring of treatment response of several other infective conditions.

Summary In this article, we summarize the available evidence and potential future applications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and management of infectious diseases.

aInfectious Diseases Division, Santa Maria Misericordia University Hospital

bCardiovascular Medicine Division, Santa Maria Misericordia University Hospital, Udine

cNational Institute for Infectious Diseases Lazzaro Spallanzani-INMI IRCCS, Rome

dNuclear Medicine Division, Santa Maria Misericordia University Hospital, Udine, Italy

eDivision of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Correspondence to Dr Matteo Bassetti, MD, PhD, Clinica Malattie Infettive, Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy. Tel: +39 0432 559355; fax: +39 0432 559360; e-mail:

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