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Current Opinion in Infectious Diseases:
doi: 10.1097/QCO.0000000000000059
PATHOGENESIS AND IMMUNE RESPONSE: Edited by Dennis L. Stevens

Mucosal immunity in HIV infection: what can be done to restore gastrointestinal-associated lymphoid tissue function?

George, Michael D.a; Asmuth, David M.a,b

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Abstract

Purpose of review

This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution.

Recent findings

Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication.

Summary

Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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