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Current Opinion in Infectious Diseases:
doi: 10.1097/QCO.0000000000000059
PATHOGENESIS AND IMMUNE RESPONSE: Edited by Dennis L. Stevens

Mucosal immunity in HIV infection: what can be done to restore gastrointestinal-associated lymphoid tissue function?

George, Michael D.a; Asmuth, David M.a,b

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Abstract

Purpose of review: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution.

Recent findings: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication.

Summary: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.

© 2014 Lippincott Williams & Wilkins, Inc.

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