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Coinfection by human immunodeficiency virus and hepatitis C virus: noninvasive assessment and staging of fibrosis

Resino, Salvadora; Sánchez-Conde, Matildeb; Berenguer, Juanb,c

Current Opinion in Infectious Diseases:
doi: 10.1097/QCO.0b013e32835635df
GASTROINTESTINAL INFECTIONS: Edited by Nicholas J. Beeching and A. Clinton White
Abstract

Purpose of review: This review presents recent findings on noninvasive alternatives for the diagnosis of fibrosis and cirrhosis in patients who are coinfected with HIV and hepatitis C virus (HCV).

Recent findings: APRI, FIB-4, and Forns were accurate indices for the diagnosis of cirrhosis [area under the receiver operating characteristic curve (AUROC) >0.80] but not for the diagnosis of significant and advanced fibrosis (AUROC < 0.80). Diagnostic accuracy was affected by CD4+ T-cell count and alanine aminotransferase levels. An artificial neural network to predict significant fibrosis was highly accurate (AUROC of 0.853), outperforming simple noninvasive indices. Derivations of the FibroMeter panel (FibroMeter2G HICV and FibroMeter3G HICV) achieved high diagnostic accuracy for significant fibrosis (AUROC of 0.823 and 0.833, respectively). Transient elastography had higher predictive accuracy than previously validated panels for diagnosis of advanced fibrosis (F ≥ 3) and cirrhosis (0.93 and 0.99, respectively). However, misclassification as F ≥ 3 was more common among patients with steatosis than among those without steatosis (25 versus 5%, P = 0.01). Moreover, transient elastography can predict clinically significant and severe portal hypertension in HIV/HCV-coinfected patients.

Summary: Both biomarkers and transient elastography can accurately diagnose fibrosis and cirrhosis and are better at excluding than at predicting liver disease in HIV/HCV-coinfected patients.

Author Information

aUnit of HIV/Hepatitis Coinfection, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda

bInfectious Diseases-HIV Unit, Hospital General Universitario ‘Gregorio Marañón’

cInstituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain

Correspondence to Salvador Resino, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda-Pozuelo Km 2.2, 28220 Majadahonda, Madrid, Spain. Tel: +34 918 223 266; fax: +34 918 223 269; e-mail: sresino@isciii.es

© 2012 Lippincott Williams & Wilkins, Inc.