Skip Navigation LinksHome > September 2011 - Volume 6 - Issue 5 > Current World Literature
Text sizing:
A
A
A
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e32834a29f4
Current World Literature: Bibliography

Current World Literature

Free Access

This bibliography is compiled by clinicians from the journals listed at the end of this publication. It is based on literature entered into our database between 1 May 2010 and 30 April 2011 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

• Papers considered by the reviewers to be of special interest

•• Papers considered by the reviewers to be of outstanding interest

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

Back to Top | Article Outline
Innate Immunity
Innate immune factors associated with HIV-1 transmission

Review: (pp. 341–347)

••. Benlahrech A. HIV-1 infection and induction of interferon alpha in plasmacytoid dendritic cells. Curr Opin HIV AIDS. 2011; 6.[40]

•. Berger A, Münk C, Schweizer M, et al. Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes. J Biol Chem 2010; 285:12248–12254.[83] PubMed | CrossRef

Braibant M, Xie J, Samri A, Agut H, et al. Disease progression due to dual infection in an HLA-B57-positive asymptomatic long-term nonprogressor infected with a nef-defective HIV-1 strain. Virology 2010; 405:81–92. PubMed | CrossRef

••. Branch DR. Blood groups and susceptibility to virus infection: new developments. Curr Opin Hematol 2010; 17:558–564.[80] View Full Text | PubMed | CrossRef

•. Cassol E, Cassetta L, Alfano M, et al. Macrophage polarization and HIV-1 infection. J Leukoc Biol 2010; 87:599–608.[12] PubMed | CrossRef

•. Centlivre M, Legrand N, Steingrover R, et al. Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. J Leukoc Biol 2011; 89:785–795.[13] PubMed | CrossRef

D'Souza MP, Axten KL, Hecht FM, Altfeld M. Acute HIV-1 Infection: What's New? Where Are We Going? Introduction. J Infect Dis 2010; 202:S267–S269. PubMed

Euler Z, van Gils MJ, Bunnik EM, Phung P, et al. Cross-Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression. J Infect Dis 2010; 201:1045–1053.

••. Guerrieri D, Tateosian NL, Maffía PC, et al. Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4(+) lymphocyte proliferation. Immunology 2011. [Epub ahead of print].[63]

••. Madsen J, Mollenhauer J, Holmskov U. Review: Gp-340/DMBT1 in mucosal innate immunity. Innate Immun 2010; 16:160–167.[64] PubMed

Nolting A, Dugast AS, Rihn S, Luteijn R, et al. MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology 2010; 406:12–20.

Ricci E, Malacrida S, Zanchetta M, Mosconi I, et al. Research Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1 - art. no. 49. J Transl Med 2010:49.

Ubol S, Halstead SB. How Innate Immune Mechanisms Contribute to Antibody-Enhanced Viral Infections [Review]. Clin Vaccine Immunol 2010; 17:1829–1835, 2010 Dec.

••. van der Vlist M, Geijtenbeek TB. Langerin functions as an antiviral receptor on Langerhans cells. Immunol Cell Biol 2010; 88:410–415.[31] View Full Text | PubMed | CrossRef

•. Venkatesh KK, van der Straten A, Cheng H, et al. The relative contribution of viral and bacterial sexually transmitted infections on HIV acquisition in southern African women in the Methods for Improving Reproductive Health in Africa study. Int J STD AIDS 2011; 22:218–224.[03] PubMed | CrossRef

Xu HB, Wang XL, Pahar B, Moroney-Rasmussen T, et al. Increased B7-H1 Expression on Dendritic Cells Correlates with Programmed Death 1 Expression on T Cells in Simian Immunodeficiency Virus-Infected Macaques and May Contribute to T Cell Dysfunction and Disease Progression. J Immunol 2010; 185:7340–7348. PubMed | CrossRef

Back to Top | Article Outline
Innate signaling in HIV-1 infection of dendritic cells

Review: (pp. 348–352)

•. Blanchet FP, Moris A, Nikolic DS, et al. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity 2010; 32:654–669.[06] View Full Text | PubMed | CrossRef

Douville RN, Hiscott J. The interface between the innate interferon response and expression of host retroviral restriction factors [Review]. Cytokine 2010; 52:108–115. View Full Text | PubMed | CrossRef

Gringhuis SI, van der Vlist M, van den Berg LM, den Dunnen J, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–NIL_81. PubMed | CrossRef

••. Gringhuis SI, van der Vlist M, van den Berg LM, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–426.[12] PubMed | CrossRef

Harmon B, Campbell N, Ratner L. Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step - art. no. e1000956. PLoS Pathogens 2010; 6:956. PubMed

•. Lambert AA, Barabe F, Gilbert C, Tremblay MJ. DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. Blood 2011.[19]

••. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–217.[21] View Full Text | PubMed | CrossRef

Mogensen TH, Melchjorsen J, Larsen CS, Paludan SR. Innate immune recognition and activation during HIV infection - art. no. 54 [Review]. Retrovirology 2010:54.

•. Nikolic DS, Lehmann M, Felts R, et al. HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation. Blood 2011.[15]

••. Pertel T, Hausmann S, Morger D, et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 2011; 472:361–365.[08] View Full Text | PubMed | CrossRef

Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, et al. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010; 11:1005–NIL_53. PubMed | CrossRef

Back to Top | Article Outline
Innate immunity in acute HIV-1 infection

Review: (pp. 353–363)

•. Alter G, Kavanagh D, Rihn S, et al. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J Clin Invest 2010; 120:1905–1913.[79] View Full Text | PubMed | CrossRef

••. Blanchet FP, Moris A, Nikolic DS, et al. Human immuno-deficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity 2010; 32:654–669.[83]

Borrow P, Shattock RJ, Vyakarnam A. Innate immunity against HIV: a priority target for HIV prevention research - art. no. 84 [Review]. Retrovirology 2010:84.

•. Boulet S, Song R, Kamya P, et al. HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells. J Immunol 2010; 184:2057–2064.[71] PubMed | CrossRef

•. Casartelli N, Sourisseau M, Feldmann J, et al. Tetherin restricts productive HIV-1 cell-to-cell transmission. PLoS Pathog 2010; 6:e1000955.[26] PubMed | CrossRef

Chang JJ, Altfeld M. Innate Immune Activation in Primary HIV-1 Infection. J Infect Dis 2010; 202:S297–S301. View Full Text | PubMed | CrossRef

•. Che KF, Sabado RL, Shankar EM, et al. HIV-1 impairs in vitro priming of naive T cells and gives rise to contact-dependent suppressor T cells. Eur J Immunol 2010; 40:2248–2258.[84] PubMed | CrossRef

•. Dube M, Roy BB, Guiot-Guillain P, et al. Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment. PLoS Pathog 2010; 6:e1000856.[23] PubMed | CrossRef

•. Fitzpatrick K, Skasko M, Deerinck TJ, et al. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog 2010; 6:e1000701.[20] PubMed | CrossRef

••. Fontaine J, Chagnon-Choquet J, Valcke HS, et al. High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV-related B-cell disease progression in humans. Blood 2011; 117:145–155.[90] PubMed | CrossRef

•. Gringhuis SI, van der Vlist M, van den Berg LM, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–426.[13] PubMed | CrossRef

•. Haase AT. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010; 464:217–223.[05] View Full Text | PubMed | CrossRef

•. Harman AN, Lai J, Turville S, et al. HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood 2011 May; [Epub ahead of print].[40]

•. Hauser H, Lopez LA, Yang SJ, et al. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology 2010; 7:51.[24] PubMed | CrossRef

•. Iwabu Y, Fujita H, Kinomoto M, et al. HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. J Biol Chem 2009; 284:35060–35072.[25] PubMed | CrossRef

•. Jolly C, Booth NJ, Neil SJ. Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells. J Virol 2010; 84:12185–12199.[28]

•. Kirchhoff F. Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses. Cell Host Microbe 2010; 8:55–67.[18] PubMed

••. Kramer HB, Lavender KJ, Qin L, et al. Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. PLoS Pathog 2010; 6:e1000893.[47] PubMed | CrossRef

•. Kuhl BD, Sloan RD, Donahue DA, et al. Tetherin restricts direct cell-to-cell infection of HIV-1. Retrovirology 2010; 7:115.[27] PubMed | CrossRef

•. Lepelley A, Louis S, Sourisseau M, et al. Innate sensing of HIV-infected cells. PLoS Pathog 2011; 7:e1001284.[45]

•. Liu J, Keele BF, Li H, et al. Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. J Virol 2010; 84:10406–10412.[06] PubMed | CrossRef

•. Lu J, Pan Q, Rong L, et al. The IFITM proteins inhibit HIV-1 infection. J Virol 2011; 85:2126–2137.[29] PubMed | CrossRef

••. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–217.[34] View Full Text | PubMed | CrossRef

•. Melki MT, Saidi H, Dufour A, et al. Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk–a pivotal role of HMGB1. PLoS Pathog 2010; 6:e1000862.[80] PubMed | CrossRef

Meyers AFA, Fowke KR. International Symposium on Natural Immunity to HIV: A Gathering of the HIV-Exposed Seronegative Clan. J Infect Dis 2010; 202:S327–S328. View Full Text | PubMed | CrossRef

Mogensen TH, Melchjorsen J, Larsen CS, Paludan SR. Innate immune recognition and activation during HIV infection - art. no. 54 [Review]. Retrovirology 2010:54.

•. Moll M, Andersson SK, Smed-Sorensen A, Sandberg JK. Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood 2010; 116:1876–1884.[89] PubMed | CrossRef

••. O'Brien M, Manches O, Sabado RL, et al. Spatiotemporal traffi-cking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype. J Clin Invest 2011; 121:1088–1101.[46]

•. Perez-Caballero D, Zang T, Ebrahimi A, et al. Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell 2009; 139:499–511.[21]

•. Pincetic A, Kuang Z, Seo EJ, Leis J. The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process. J Virol 2010; 84:4725–4736.[30]

•. Richard J, Sindhu S, Pham TN, et al. HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing. Blood 2010; 115:1354–1363.[62] PubMed | CrossRef

•. Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852.[50] PubMed | CrossRef

••. Schoggins JW, Wilson SJ, Panis M, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2011; 472:481–485.[17]

••. Shah AH, Sowrirajan B, Davis ZB, et al. Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe 2010; 8:397–409.[73] PubMed

•. Shankar EM, Che KF, Messmer D, et al. Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells. Mol Med 2011; 17:229–240.[85] PubMed

•. Singh R, Gaiha G, Werner L, et al. Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol 2011; 85:208–216.[31] PubMed | CrossRef

••. Solis M, Nakhaei P, Jalalirad M, et al. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J Virol 2011; 85:1224–1236.[37] PubMed | CrossRef

•. Stone M, Keele BF, Ma ZM, et al. A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251. J Virol 2010; 84:7083–7095.[07] PubMed | CrossRef

Streeck H, Nixon DF. T Cell Immunity in Acute HIV-1 Infection. J Infect Dis 2010; 202:S302–S308. View Full Text | PubMed | CrossRef

•. Ward J, Davis Z, De Hart J, et al. HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. PLoS Pathog 2009; 5:e1000613.[63] PubMed | CrossRef

•. Wijewardana V, Soloff AC, Liu X, et al. Early myeloid dendritic cell dysregulation is predictive of disease progression in simian immunodeficiency virus infection. PLoS Pathog 2010; 6:e1001235.[55] PubMed | CrossRef

••. Yan N, Regalado-Magdos AD, Stiggelbout B, et al. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010; 11:1005–1013.[38] PubMed | CrossRef

•. Zhang J, Liang C. BST-2 diminishes HIV-1 infectivity. J Virol 2010; 84:12336–12343.[22] PubMed | CrossRef

Back to Top | Article Outline
Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: a dangerous trio in HIV-1 infection?

Review: (pp. 364–372)

•. Alter G, Kavanagh D, Rihn S, et al. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J Clin Invest 2010; 120:1905–1913.[47] View Full Text | PubMed | CrossRef

Bjorkstrom NK, Ljunggren HG, Sandberg JK. CD56 negative NK cells: origin, function, and role in chronic viral disease [Review]. Trends Immunol 2010; 31:401–406. PubMed | CrossRef

•. Brackenridge S, Evans EJ, Toebes M, et al. An early HIV mutation within a HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1 (KIR3DL1). J Virol 2011; 85:5415–5422.[23]

Fu GF, Chen X, Hao S, Zhao JL, et al. Differences in natural killer cell quantification and receptor profile expression in HIV-1 infected Chinese children. Cell Immunol 2010; 265:37–43. PubMed | CrossRef

Gulzar N, Shroff A, Buberoglu B, Klonowska D, et al. Properties of HTLV-I transformed CD8(+) T-cells in response to HIV-1 infection. Virology 2010; 406:302–311. PubMed | CrossRef

•. Izquierdo-Useros N, Naranjo-Gomez M, Erkizia I, et al. HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse? Plos Pathogens 2010; 6.[65]

•. Lamkanfi M, Sarkar A, Walle LV, et al. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 2010; 185:4385–4392.[74]

•. Melki MT, Saidi H, Dufour A, et al. Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk: a pivotal role of HMGB1. Plos Pathogens 2010; 6.[48]

Melki MT, Saidi H, Dufour A, Olivo-Marin JC, et al. Escape of HIV-1-Infected Dendritic Cells from TRAIL-Mediated NK Cell Cytotoxicity during NK-DC Cross-Talk-A Pivotal Role of HMGB1 - art. no. e1000862. PLoS Pathogens 2010; 6:862. PubMed

Ni ZY, Knorr DA, Clouser CL, Hexum MK, et al. Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms. J Virol 2011; 85:43–50. PubMed | CrossRef

•. Richard J, Sindhu S, Pham TNQ, et al. HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing. Blood 2010; 115:1354–1363.[37] PubMed | CrossRef

Rutjens E, Mazza S, Biassoni R, Koopman G, et al. CD8(+) NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV-1 infection. Eur J Immunol 2010; 40:1440–1450. PubMed | CrossRef

Tiemessen CT, Shalekoff S, Meddows-Taylor S, Schramm DB, et al. Natural Killer Cells That Respond to Human Immunodeficiency Virus Type 1 (HIV-1) Peptides Are Associated with Control of HIV-1 Infection. J Infect Dis 2010; 202:1444–1453. View Full Text | PubMed | CrossRef

•. Zhu P, Duan L, Chen J, et al. Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice. Hum Gene Ther 2011.[75]

Back to Top | Article Outline
HIV-1 infection and induction of interferon alpha in plasmacytoid dendritic cells

Review: (pp. 373–378)

•. Brown KN, Wijewardana V, Liu X, Barratt-Boyes SM. Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infection. PLoS Pathog 2009; 5:e1000413.[32] PubMed | CrossRef

Dobson-Belaire WN, Rebbapragada A, Malott RJ, Yue FY, et al. Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-alpha response from plasmacytoid dendritic cells. Cell Microbiol 2010; 12:1703–1717. PubMed | CrossRef

Hao WL, Liu Y, Liu SR, Walter S, et al. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology. Brain 2011; 134:278–292. View Full Text | PubMed | CrossRef

••. Harris LD, Tabb B, Sodora DL, et al. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. J Virol 2010; 84:7886–7891.[23] PubMed | CrossRef

Huang JH, Burke PS, Cung TDH, Pereyra F, et al. Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers. J Virol 2010; 84:9463–9471.

Kodama A, Tanaka R, Zhang LF, Adachi T, et al. Impairment of in vitro generation of monocyte-derived human dendritic cells by inactivated human immunodeficiency virus-1: Involvement of type I interferon produced from plasmacytoid dendritc cells. Hum Immunol 2010; 71:541–550. PubMed | CrossRef

••. Li Q, Estes JD, Schlievert PM, et al. Glycerol monolaurate prevents mucosal SIV transmission. Nature 2009; 458:1034–1038.[16] View Full Text | PubMed | CrossRef

Manel N, Hogstad B, Wang YM, Levy DE, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–NIL_104. View Full Text | PubMed | CrossRef

•. Meier A, Chang JJ, Chan ES, et al. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med 2009; 15:955–959.[21] PubMed | CrossRef

••. O'Brien M, Manches O, Sabado RL, et al. Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype. J Clin Invest 2011; 121:1088–1101.[70]

Peressin M, Holl V, Schmidt S, Decoville T, et al. HIV-1 Replication in Langerhans and Interstitial Dendritic Cells Is Inhibited by Neutralizing and Fc-Mediated Inhibitory Antibodies. J Virol 2011; 85:1077–1085. PubMed | CrossRef

•. Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852.[31] PubMed | CrossRef

Tomescu C, Duh FM, Lanier MA, Kapalko A, et al. Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intravenous drug users. AIDS 2010; 24:2151–2160. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Myeloid dendritic cells in HIV-1 infection

Review: (pp. 379–384)

••. Cheong C, Choi JH, Vitale L, et al. Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human antihuman DEC205 monoclonal antibody. Blood 2010; 116:3828–3838.[59] PubMed | CrossRef

•. De Jong MA, de Witte L, Taylor ME, Geijtenbeek TB. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol 2010; 185:1633–1641.[18] PubMed | CrossRef

•. Dillon SM, Friedlander LJ, Rogers LM, et al. Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory study. J Virol 2011; 85:397–409.[08] PubMed | CrossRef

•. Gringhuis SI, van der Vlist M, van den Berg LM, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–426.[34] PubMed | CrossRef

Hao WL, Liu Y, Liu SR, Walter S, et al. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology. Brain 2011; 134:278–292. View Full Text | PubMed | CrossRef

••. Harman AN, Lai J, Turville S, et al. HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood 2011.[37]

•. Hong B, Song XT, Rollins L, et al. Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells. J Clin Invest 2011; 121:739–751.[67] View Full Text | PubMed | CrossRef

Huang JH, Burke PS, Cung TDH, Pereyra F, et al. Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers. J Virol 2010; 84:9463–9471.

••. Laguette N, Sobhian B, Casartelli N, et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 2011.[40]

••. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–217.[39] View Full Text | PubMed | CrossRef

Manel N, Hogstad B, Wang YM, Levy DE, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–NIL_104. View Full Text | PubMed | CrossRef

••. Martinelli E, Tharinger H, Frank I, et al. HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target. PLoS Pathog 2011.[19]

•. Nawaz F, Cicala C, Van Ryk D, et al. The genotype of early-transmitting HIV gp120s promotes alpha(4)beta(7)-reactivity, revealing alpha(4)beta(7)/CD4 T cells as key targets in mucosal transmission. PLoS Pathog 2011; 7:e1001301.[22] PubMed | CrossRef

•. Nchinda G, Amadu D, Trumpfheller C, et al. Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells. Proc Natl Acad Sci USA 2010; 107:4281–4286.[55] PubMed | CrossRef

Peressin M, Holl V, Schmidt S, Decoville T, et al. HIV-1 Replication in Langerhans and Interstitial Dendritic Cells Is Inhibited by Neutralizing and Fc-Mediated Inhibitory Antibodies. J Virol 2011; 85:1077–1085. PubMed | CrossRef

••. Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852.[11] PubMed | CrossRef

•. Schlaepfer E, Speck RF. TLR8 activates HIV from latently infected cells of myeloid-monocytic origin directly via the MAPK pathway and from latently infected CD4+ T cells indirectly via TNF-α. J Immunol 2011.[10]

•. Sunseri N, O'Brien M, Bhardwaj N, Landau NR. HIV-1 modified to package SIV Vpx efficiently infects macrophages and dendritic cells. J Virol 2011.[41]

•. Taylor PR, Koski GK, Paustian CC, et al. J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells. Vaccine 2010; 28:5533–5542.[61] PubMed | CrossRef

•. Vagenas P, Aravantinou M, Williams VG, et al. A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS One 2010; 5:e12891.[51] PubMed | CrossRef

Vazquez M, Maldonado IM, Almodovar S, Lopez C, et al. Short Communication: Human Blood Dendritic Cells Are Infected Separately from Monocytes in HIV Type 1 Patients. AIDS Res Hum Retroviruses 2010; 26:471–479.

••. Wijewardana V, Soloff AC, Liu X, et al. Early myeloid dendritic cell dysregulation is predictive of disease progression in simian immunodeficiency virus infection. PLoS Pathog 2010; 6:e1001235.[07] PubMed | CrossRef

•. Xu H, Wang X, Pahar B, et al. Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression. J Immunol 2010; 185:7340–7348.[12] PubMed | CrossRef

Back to Top | Article Outline
Macrophages and HIV-1

Review: (pp. 385–390)

Ahmed N, Hayashi T, Hasegawa A, Furukawa H, et al. Suppression of human immunodeficiency virus type 1 replication in macrophages by commensal bacteria preferentially stimulating Toll-like receptor 4. J Gen Virol 2010; 91:2804–2813. PubMed | CrossRef

Akhtar LN, Qin HW, Muldowney MT, Yanagisawa LL, et al. Suppressor of Cytokine Signaling 3 Inhibits Antiviral IFN-beta Signaling To Enhance HIV-1 Replication in Macrophages. J Immunol 2010; 185:2393–2404.

Ayinde D, Maudet C, Transy C, Margottin-Goguet F. Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr? - art. no. 35 [Review]. Retrovirology 2010:35.

Bergamaschi A, Pancino G. Host hindrance to HIV-1 replication in monocytes and macrophages - art. no. 31 [Review]. Retrovirology 2010:31.

•. Bol SM, Moerland PD, Limou S, et al. Genomewide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages. PLoS One 2011; 6:e17190.[09]

•. Carter GC, Bernstone L, Baskaran D, et al. HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1. Virology 2011; 409:234–250.[11] PubMed | CrossRef

Cimarelli A. Journey to the heart of macrophages: the delicate relationship between HIV-1 and a multifaceted cell type - art. no. 28. Retrovirology 2010:28.

Coley W, Van Duyne R, Carpio L, Guendel I, et al. Absence of DICER in Monocytes and Its Regulation by HIV-1. J Biol Chem 2010; 285:31930–31943. PubMed | CrossRef

Collini P, Noursadeghi M, Sabroe I, Miller RF, et al. Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity [Review]. Current Molecular Medicine 2010; 10:727–740. PubMed | CrossRef

Dai L, Stevenson M. A Novel Motif in HIV-1 Nef That Regulates MIP-1 beta Chemokine Release in Macrophages. J Virol 2010; 84:8327–8331. PubMed | CrossRef

•. Eggert D, Dash PK, Gorantla S, et al. Neuroprotective activities of CEP-1347 in models of neuroAIDS. J Immunol 2010; 184:746–756.[57] PubMed | CrossRef

Goujon C, Malim MH. Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T Cells. J Virol 2010; 84:9254–9266. PubMed | CrossRef

Gras G, Kaul M. Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection - art. no. 30 [Review]. Retrovirology 2010:30.

Hagiwara K, Murakami T, Xue GG, Shimizu Y, et al. Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array. Biochem Biophys Res Commun 2010; 403:40–45. PubMed | CrossRef

Herbein G, Gras G, Khan KA, Abbas W. Macrophage signaling in HIV-1 infection - art. no. 34 [Review]. Retrovirology 2010:34.

Herbein G, Varin A. The macrophage in HIV-1 infection: From activation to deactivation? - art. no. 33 [Review]. Retrovirology 2010:33.

Huang XY, Stone DK, Yu F, Zeng YY, et al. Functional Proteomic Analysis for Regulatory T Cell Surveillance of the HIV-1-Infected Macrophage. J Proteome Res 2010; 9:6759–6773. PubMed | CrossRef

Kadoki M, Choi BI, Iwakura Y. The mechanism of LPS-induced HIV type I activation in transgenic mouse macrophages. Int Immunol 2010; 22:469–478. View Full Text | PubMed | CrossRef

Kaner RJ, Santiago F, Rahaghi F, Michaels E, et al. Adenovirus Vectors Block Human Immunodeficiency Virus-1 Replication in Human Alveolar Macrophages by Inhibition of the Long Terminal Repeat. Am J Respir Cell Mol Biol 2010; 43:234–242. PubMed | CrossRef

Kennedy EM, Gavegnano C, Nguyen L, Slater R, et al. Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages. J Biol Chem 2010; 285:39380–39391. PubMed | CrossRef

Mazzolini J, Herit F, Bouchet J, Benmerah A, et al. Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments. Blood 2010; 115:4226–4236. PubMed | CrossRef

•. Mazzolini J, Herit F, Bouchet J, et al. Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments. Blood 2010; 115:4226–4236.[48] PubMed | CrossRef

Muratori C, Mangino G, Affabris E, Federico M. Astrocytes Contacting HIV-1-Infected Macrophages Increase the Release of CCL2 in Response to the HIV-1-Dependent Enhancement of Membrane-Associated TNF alpha in Macrophages. Glia 2010; 58:1893–1904. PubMed | CrossRef

Pathak S, Wentzel-Larsen T, Asjo B. Effects of In Vitro HIV-1 Infection on Mycobacterial Growth in Peripheral Blood Monocyte-Derived Macrophages. Infect Immun 2010; 78:4022–4032. PubMed | CrossRef

Rozmyslowicz T, Murphy SL, Conover DO, Gaulton GN. HIV-1 infection inhibits cytokine production in human thymic macrophages. Exp Hematol 2010; 38:1157–1166. PubMed | CrossRef

•. Said EA, Dupuy FP, Trautmann L, et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010; 16:452–459.[47]

•. Schouten J, Cinque P, Gisslen M, et al. HIV-1 infection and cognitive impairment in the cART-era: a review. AIDS 2010; 25:561–575.[72]

Van den Bergh R, Florence E, Vlieghe E, Boonefaes T, et al. Transcriptome analysis of monocyte-HIV interactions - art. no. 53. Retrovirology 2010:53.

Vazquez M, Maldonado IM, Almodovar S, Lopez C, et al. Short Communication: Human Blood Dendritic Cells Are Infected Separately from Monocytes in HIV Type 1 Patients. AIDS Res Hum Retroviruses 2010; 26:471–479.

Verollet C, Zhang YM, Le Cabec V, Mazzolini J, et al. HIV-1 Nef Triggers Macrophage Fusion in a p61Hck-and Protease-Dependent Manner. J Immunol 2010; 184:7030–7039. PubMed | CrossRef

••. Yan N, Regalado-Magdos AD, Stiggelbout B, et al. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010; 11:1005–1013.[42] PubMed | CrossRef

Zalar A, Figueroa MI, Ruibal-Ares B, Bare P, et al. Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART. Antiviral Res 2010; 87:269–271. View Full Text | PubMed | CrossRef

Zhou Y, Wang X, Liu MQ, Hu QA, et al. A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology 2010; 131:40–49. View Full Text | PubMed

Back to Top | Article Outline
A look at HIV journey: from dendritic cells to infection spread in CD4+ T cells

Review: (pp. 391–397)

••. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329:1168–1174.[46] View Full Text | PubMed | CrossRef

Arora R, Bull L, Siwak EB, Thippeshappa R, et al. Dendritic Cell-Mediated HIV-1 Infection of T Cells Demonstrates a Direct Relationship to Plasma Viral RNA Levels. JAIDS 2010; 54:115–121. View Full Text | PubMed

•. Blanchet FP, Moris A, Nikolic DS, et al. Human immuno-deficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity 2010; 32:654–669.[36]

Blanchet FP, Moris A, Nikolic DS, Lehmann M, et al. Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses. Immunity 2010; 32:654–669. View Full Text | PubMed | CrossRef

••. Bomsel M, Tudor D, Drillet AS, et al. Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal Simian-Human Immunodeficiency Virus challenges. Immunity 2011; 34:269–280.[48]

•. Brandler S, Lepelley A, Desdouits M, et al. Preclinical studies of a modified vaccinia virus Ankara-based HIV candidate vaccine: antigen presentation and antiviral effect. J Virol 2010; 84:5314–5328.[50] PubMed | CrossRef

•. Casartelli N, Guivel-Benhassine F, Bouziat R, et al. The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells. J Exp Med 2010; 207:39–49.[57] PubMed | CrossRef

Collini P, Noursadeghi M, Sabroe I, Miller RF, et al. Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity [Review]. Current Molecular Medicine 2010; 10:727–740. PubMed | CrossRef

Decker WK, Safdar A. Dendritic cell vaccines for the immunocompromised patient: prevention of influenza virus infection [Review]. Expert Rev Vaccines 2010; 9:721–730. View Full Text | PubMed | CrossRef

Dobson-Belaire WN, Rebbapragada A, Malott RJ, Yue FY, et al. Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-alpha response from plasmacytoid dendritic cells. Cell Microbiol 2010; 12:1703–1717. PubMed | CrossRef

••. Felts RL, Narayan K, Estes JD, et al. 3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells. Proc Natl Acad Sci U S A 2010; 107:13336–13341.[31] PubMed | CrossRef

•. Ganor Y, Zhou Z, Tudor D, et al. Within 1h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates. Mucosal Immunol 2010; 3:506–522.[28]

Gonzalez N, Bermejo M, Calonge E, Jolly C, et al. SDF-1/CXCL12 Production by Mature Dendritic Cells Inhibits the Propagation of X4-Tropic HIV-1 Isolates at the Dendritic Cell-T-Cell Infectious Synapse. J Virol 2010; 84:4341–4351. PubMed | CrossRef

Gringhuis SI, van der Vlist M, van den Berg LM, den Dunnen J, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–NIL_81. PubMed | CrossRef

••. Gringhuis SI, van der Vlist M, van den Berg LM, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–426.[35] PubMed | CrossRef

Hanley TM, Puryear WB, Gummuluru S, Viglianti GA. PPAR gamma and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection - art. no. e1000981. PLoS Pathogens 2010; 6:981. PubMed

Hao WL, Liu Y, Liu SR, Walter S, et al. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology. Brain 2011; 134:278–292. View Full Text | PubMed | CrossRef

Holl V, Xu K, Peressin M, Lederle A, et al. Stimulation of HIV-1 Replication in Immature Dendritic Cells in Contact with Primary CD4 T or B Lymphocytes. J Virol 2010; 84:4172–4182. PubMed | CrossRef

Huang JH, Burke PS, Cung TDH, Pereyra F, et al. Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers. J Virol 2010; 84:9463–9471.

Kodama A, Tanaka R, Zhang LF, Adachi T, et al. Impairment of in vitro generation of monocyte-derived human dendritic cells by inactivated human immunodeficiency virus-1: Involvement of type I interferon produced from plasmacytoid dendritc cells. Hum Immunol 2010; 71:541–550. PubMed | CrossRef

Loke P, Favre D, Hunt PW. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers (vol 115, pg e20, 2010). Blood 2010; 116:2402. PubMed | CrossRef

••. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–217.[37] View Full Text | PubMed | CrossRef

Manel N, Hogstad B, Wang YM, Levy DE, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–NIL_104. View Full Text | PubMed | CrossRef

Mojumdar K, Vajpayee M, Chauhan NK, Mendiratta S, et al. Defects in blood dendritic cell subsets in HIV-1 subtype C infected Indians. Indian J Med Res 2010; 132:318–327. PubMed

Sajadi MM, Shakeri N, Talwani R, Redfield RR. Hepatitis C infection in HIV-1 natural viral suppressors. AIDS 2010; 24:1689–1695. View Full Text | PubMed | CrossRef

••. Sui Y, Zhu Q, Gagnon S, et al. Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques. Proc Natl Acad Sci U S A 2010; 107:9843–9848.[55] PubMed | CrossRef

Suzuki J, Ricordi C, Chen ZB. Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators [Review]. Cell Transplant 2010; 19:253–268. PubMed | CrossRef

Tomescu C, Duh FM, Lanier MA, Kapalko A, et al. Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intravenous drug users. AIDS 2010; 24:2151–2160. View Full Text | PubMed | CrossRef

Vazquez M, Maldonado IM, Almodovar S, Lopez C, et al. Short Communication: Human Blood Dendritic Cells Are Infected Separately from Monocytes in HIV Type 1 Patients. AIDS Res Hum Retroviruses 2010; 26:471–479.

Viswanathan K, Fruh K, De Filippis V. Viral hijacking of the host ubiquitin system to evade interferon responses [Review]. Curr Opin Microbiol 2010; 13:517–523. PubMed | CrossRef

Yagi Y, Watanabe E, Watari E, Shinya E, et al. Inhibition of DC-SIGN-mediated transmission of human immunodeficiency virus type 1 by Toll-like receptor 3 signalling in breast milk macrophages. Immunology 2010; 130:597–607. View Full Text | PubMed | CrossRef

Zhou Y, Wang X, Liu MQ, Hu QA, et al. A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology 2010; 131:40–49. View Full Text | PubMed

Back to Top | Article Outline
Induction of innate immunity in control of mucosal transmission of HIV

Review: (pp. 398–404)

Asefa B, Korokhov N, Lemiale F. Heterologous HIV-based lentiviral/adenoviral vectors immunizations result enhanced HIV-specific immunity. Vaccine 2010; 28:3617–3624. PubMed

•. Casartelli N, Guivel-Benhassine F, Bouziat R, et al. The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells. J Exp Med 2010; 207:39–49.[34] PubMed | CrossRef

•. De Paolo RW, Abadie V, Tang F, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 2011; 471:220–224.[13]

Fraietta JA, Mueller YM, Do DH, Holmes VM, et al. Phosphorothioate 2 ' Deoxyribose Oligomers as Microbicides That Inhibit Human Immunodeficiency Virus Type 1 (HIV-1) Infection and Block Toll-Like Receptor 7 (TLR7) and TLR9 Triggering by HIV-1. Antimicrob Agents Chemother 2010; 54:4064–4073. PubMed | CrossRef

•. Ganor Y, Zhou Z, Tudor D, et al. Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates. Mucosal Immunol 2010; 3:506–522.[09]

•. Geldmacher C, Ngwenyama N, Schuetz A, et al. Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection. J Exp Med 2010; 207:2869–2881.[30]

••. Haase AT. Early events in sexual transmission of HIV and SIV and opportunities for interventions. Annu Rev Med 2011; 62:127–139.[02] PubMed | CrossRef

•. Hansen SG, Vieville C, Whizin N, et al. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med 2009; 15:293–299.[31] PubMed | CrossRef

Hervouet C, Luci C, Cuburu N, Cremel M, et al. Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract. Vaccine 2010; 28:5582–5590. PubMed | CrossRef

Jespers V, Harandi AM, Hinkula J, Medaglini D, et al. Assessment of mucosal immunity to HIV-1. Expert Rev Vaccines 2010; 9:381–394. View Full Text | PubMed | CrossRef

Kaushic C, Ferreira VH, Kafka JK, Nazli A. HIV Infection in the Female Genital Tract: Discrete Influence of the Local Mucosal Microenvironment [Review]. Am J Reprod Immunol 2010; 63:566–575. View Full Text | PubMed | CrossRef

Langridge W, Denes B, Fodor I. Cholera toxin B subunit modulation of mucosal vaccines for infectious and autoimmune diseases [Review]. Curr Opin Investig Drugs 2010; 11:919–928. PubMed

••. Li Q, Estes JD, Schlievert PM, et al. Glycerol monolaurate prevents mucosal SIV transmission. Nature 2009; 458:1034–1038.[03] View Full Text | PubMed | CrossRef

Loke P, Favre D, Hunt PW, Leung JM, et al. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Blood 2010; 115:E20–E32. PubMed | CrossRef

•. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 476:214–219.[15]

Mogensen TH, Melchjorsen J, Larsen CS, Paludan SR. Innate immune recognition and activation during HIV infection - art. no. 54 [Review]. Retrovirology 2010:54.

Patel GB, Chen WX. Archaeal lipid mucosal vaccine adjuvant and delivery system [Review]. Expert Rev Vaccines 2010; 9:431–440. View Full Text | PubMed | CrossRef

•. Paust S, Gill HS, Wang BZ, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol 2010; 11:1127–1135.[60]

•. Pido-Lopez J, Wang Y, Seidl T, et al. The effect of allogeneic in vitro stimulation and in vivo immunization on memory CD4(+) T-cell APOBEC3G expression and HIV-1 infectivity. Eur J Immunol 2009; 39:1956–1965.[41]

Pudney J, Anderson DJ. Expression of Toll-like Receptors in Genital Tract Tissues from Normal and HIV-infected Men. Am J Reprod Immunol 2011; 65:28–43. View Full Text | PubMed | CrossRef

•. Saba E, Grivel JC, Vanpouille C, et al. HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model. Mucosal Immunol 2010; 3:280–290.[07]

Sabado RL, O'Brien M, Subedi A, Qin L, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852. PubMed | CrossRef

••. Schoggins JW, Wilson SJ, Panis M, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2011. [Epub ahead of print][50]

••. Sui Y, Zhu Q, Gagnon S, et al. Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques. Proc Natl Acad Sci U S A 2010; 107:9843–9848.[43] PubMed | CrossRef

Takahashi H. Species-specific CD1-restricted innate immunity for the development of HIV vaccine. Vaccine 2010; 28:B3–B7. PubMed | CrossRef

••. Wang Y, Bergmeier LA, Stebbing R, et al. Mucosal immunization in macaques upregulates the innate APOBEC 3G antiviral factor in CD4(+) memory T cells. Vaccine 2009; 27:870–881.[42] PubMed | CrossRef

•. Wang Y, Seidl T, Whittall T, et al. Stress-activated dendritic cells interact with CD4+ T cells to elicit homeostatic memory. Eur J Immunol 2010; 40:1628–1638.[54] PubMed | CrossRef

Wira CR, Fahey JV, Ghosh M, Patel MV, et al. Sex Hormone Regulation of Innate Immunity in the Female Reproductive Tract: The Role of Epithelial Cells in Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens [Review]. Am J Reprod Immunol 2010; 63:544–565. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Dendritic cells at the interface of innate and adaptive immunity to HIV-1

Review: (pp. 405–410)

••. Alter G, Kavanagh D, Rihn S, et al. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J Clin Invest 2010; 120:1905–1913.[55] View Full Text | PubMed | CrossRef

•. Bachem A, Guttler S, Hartung E, et al. Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med 2010; 207:1273–1281.[02]

Barra NG, Gillgrass A, Ashkar AA. Effective control of viral infections by the adaptive immune system requires assistance from innate immunity. Expert Rev Vaccines 2010; 9:1143–1147. View Full Text | PubMed | CrossRef

•. Crozat K, Guiton R, Contreras V, et al. The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells. J Exp Med 2010; 207:1283–1292.[03] PubMed | CrossRef

Feng YM, Zhang RJ, Zhu H, Peng H, et al. Comparison of the quantities and subset distributions of natural killer cells among different races. Chin Med J 2010; 123:3272–3276. View Full Text | PubMed

Gerberry DJ, Blower S. Predicting the level of vaccine-induced cross-immunity necessary to eliminate HIV epidemics com-posed of multiple subtypes. AIDS 2010; 24:1604–1606. View Full Text | PubMed | CrossRef

•. Jongbloed SL, Kassianos AJ, McDonald KJ, et al. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med 2010; 207:1247–1260.[04]

••. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–217.[35] View Full Text | PubMed | CrossRef

•. Martinson JA, Montoya CJ, Usuga X, et al. Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation. Antimicrob Agents Chemother 2010; 54:871–881.[63] PubMed | CrossRef

Melki MT, Saidi H, Dufour A, Olivo-Marin JC, et al. Escape of HIV-1-Infected Dendritic Cells from TRAIL-Mediated NK Cell Cytotoxicity during NK-DC Cross-Talk-A Pivotal Role of HMGB1 - art. no. e1000862. PLoS Pathogens 2010; 6:862. PubMed

••. Moll M, Andersson SK, Smed-Sorensen A, Sandberg JK. Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endo-somal compartments. Blood 2010; 116:1876–1884.[74] PubMed | CrossRef

••. O'Brien M, Manches O, Sabado RL, et al. Spatiotemporal traffi-cking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype. J Clin Invest 2011; 121:1088–1101.[41]

•. Poulin LF, Salio M, Griessinger E, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med 2010; 207:1261–1271.[05] PubMed | CrossRef

••. Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852.[30] PubMed | CrossRef

•. Shankar EM, Che KF, Messmer D, et al. Expression of a broad array of negative costimulatory molecules and Blimp-1 in T-cells following priming by HIV-1 pulsed dendritic cells. Mol Med 2011; 17:229–240.[67] PubMed

••. Wijewardana V, Soloff AC, Liu X, et al. Early myeloid dendritic cell dysregulation is predictive of disease progression in simian immunodeficiency virus infection. PLoS Pathog 2010; 6:e1001235.[59] PubMed | CrossRef

Back to Top | Article Outline
Generalized immune activation and innate immune responses in simian immunodeficiency virus infection

Review: (pp. 411–418)

•. Ansari AA, Reimann KA, Mayne AE, et al. Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J Immunol 2011; 186:1044–1059.[34] PubMed | CrossRef

Barratt-Boyes SM, Wijewardana V, Brown KN. In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization. J Med Primatol 2010; 39:235–242. View Full Text | PubMed | CrossRef

••. Bosinger SE, Li Q, Gordon SN, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest 2009; 119:3556–3572.[42]

Burdo TH, Soulas C, Orzechowski K, Button J, et al. Increased Monocyte Turnover from Bone Marrow Correlates with Severity of SIV Encephalitis and CD163 Levels in Plasma - art. no. e1000842. PLoS Pathogens 2010; 6:842. PubMed

•. Campillo-Gimenez L, Laforge M, Fay M, et al. Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase. J Virol 2010; 84:1838–1846.[47]

Easlick J, Szubin R, Lantz S, Baumgarth N, et al. The Early Interferon Alpha Subtype Response in Infant Macaques Infected Orally With SIV. JAIDS 2010; 55:14–28. View Full Text | PubMed | CrossRef

••. Harris LD, Tabb B, Sodora DL, et al. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. J Virol 2010; 84:7886–7891.[46] PubMed | CrossRef

••. Jacquelin B, Mayau V, Targat B, et al. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest 2009; 119:3544–3555.[43]

•. Kwa S, Kannanganat S, Nigam P, et al. Plasmacytoid dendritic cells express β7-integrin and are recruited to the colorectum during pathogenic SIV infection. Abstract# P09.10 AIDS Vaccine 2010. Sept 28–Oct 1; Atlanta, GA, USA; 2010.[32]

••. O'Brien M, Manches O, Sabado RL, et al. Spatiotemporal traffi-cking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype. J Clin Invest 2011; 121:1088–1101.[39]

•. Reeves RK, Evans T, Gillis J, et al. SIV infection induces increased trafficking of pDC to gut mucosa. Abstract# 23 18th Conference on Retroviruses and Opportunistic Infections. Feb 27–Mar 2; Boston, MA, USA; 2011.[33]

Reeves RK, Evans TI, Gillis J, Johnson RP. Simian Immunodeficiency Virus Infection Induces Expansion of alpha 4 beta 7(+) and Cytotoxic CD56(+) NK Cells. J Virol 2010; 84:8959–8963. PubMed | CrossRef

••. Rotger M, Dalmau J, Rauch A, et al. Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest 2011.[51]

••. Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852.[38] PubMed | CrossRef

Xia HJ, Zhang GH, Ma JP, Dai ZX, et al. Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques - art. no. 102. Retrovirology 2010:102.

Back to Top | Article Outline
Emerging role for complement in HIV infection

Review: (pp. 419–426)

•. Banki Z, Posch W, Ejaz A, et al. Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs. PLoS Pathog 2010; 6:e1000891.[105] PubMed | CrossRef

•. Eisen DP. Mannose-binding lectin deficiency and respiratory tract infection. J Innate Immun 2009; 2:114–122.[09]

Jia LL, Xu YY, Zhang CF, Wang Y, et al. A novel trifunctional IgG-like bispecific antibody to inhibit HIV-1 infection and enhance lysis of HIV by targeting activation of complement - art. no. 142. Virol J 2010:142.

••. Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol 2010; 11:785–797.[03] PubMed | CrossRef

Yu QG, Yu R, Qin XB. The good and evil of complement activation in HIV-1 infection [Review]. Cell Mol Immunol 2010; 7:334–340. PubMed

•. Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol 2009; 9:729–740.[16] PubMed | CrossRef

Back to Top | Article Outline
Host genetic polymorphisms associated with innate immune factors and HIV-1

Review: (pp. 427–434)

••. Bashirova AA, Thomas R, Carrington M. HLA/KIR restraint of HIV: surviving the fittest. Annu Rev Immunol 2011; 29:295–317.[56] PubMed | CrossRef

Braibant M, Xie J, Samri A, Agut H, et al. Disease progression due to dual infection in an HLA-B57-positive asymptomatic long-term nonprogressor infected with a nef-defective HIV-1 strain. Virology 2010; 405:81–92. PubMed | CrossRef

Chaichompoo P, Bostik P, Stephenson S, Udompunturuk S, et al. Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques. Cell Immunol 2010; 263:176–187. PubMed | CrossRef

Chatterjee A, Rathore A, Yamamoto N, Dhole TN. Mannose-binding lectin (+54) exon-1 gene polymorphism influence human immunodeficiency virus-1 susceptibility in North Indians. Tissue Antigens 2011; 77:18–22. View Full Text | PubMed | CrossRef

•. Le Clerc S, Coulonges C, De laneau O, et al. Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS. J Acquir Immune Defic Syndr 2011; 56:279–284.[31]

••. No Authors Given. The International HIV Controllers Study. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 2010; 330:1551–1557.[01]

Nolting A, Dugast AS, Rihn S, Luteijn R, et al. MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology 2010; 406:12–20.

•. Onyango CO, Leligdowicz A, Yokoyama M, et al. HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine 2010; S2:B60–B67.[80]

Papadopoulos AI, Ferwerda B, Antoniadou A, Sakka V, et al. Association of Toll-Like Receptor 4 Asp299Gly and Thr399Ile Polymorphisms with Increased Infection Risk in Patients with Advanced HIV-1 Infection. Clin Infect Dis 2010; 51:242–247. View Full Text | PubMed | CrossRef

Plantinga TS, Hamza OJM, Willment JA, Ferwerda B, et al. Genetic Variation of Innate Immune Genes in HIV-Infected African Patients With or Without Oropharyngeal Candidiasis. JAIDS 2010; 55:87–94. View Full Text | PubMed | CrossRef

•. Reddy K, Winkler CA, Werner L, et al. APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load. AIDS 2010; 24:195–204.[41] View Full Text | PubMed | CrossRef

••. Rotger M, Dang KK, Fellay J, et al. Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals. PLoS Pathog 2010; 6:e1000781.[35]

Xu HB, Wang XL, Pahar B, Moroney-Rasmussen T, et al. Increased B7-H1 Expression on Dendritic Cells Correlates with Programmed Death 1 Expression on T Cells in Simian Immunodeficiency Virus-Infected Macaques and May Contribute to T Cell Dysfunction and Disease Progression. J Immunol 2010; 185:7340–7348. PubMed | CrossRef

•. Yindom L-M, Leligdowicz A, Martin MP, et al. Influence of HLA class I and HLA–KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako Community in West Africa. J Virol 2010; 84:8202–8208.[82] PubMed | CrossRef

•. Zhen A, Wang T, Zhao K, et al. Single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity. J Virol 2010; 84:1902–1911.[47] PubMed | CrossRef

Back to Top | Article Outline
Targeting HIV-1 innate immune responses therapeutically

Review: (pp. 435–443)

••. Abdool Karim Q, Abdool Karim S, Frohlich J, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329:1168–1174.[79] View Full Text | PubMed | CrossRef

•. Ahmed N, Hayashi T, Hasegawa A, et al. Suppression of human immunodeficiency virus type 1 replication in macrophages by commensal bacteria preferentially stimulating Toll-like receptor 4. J Gen Virol 2010; 91:2804–2813.[28] PubMed | CrossRef

•. Albin J, Haché G, Hultquist J, et al. Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function. J Virol 2010; 84:10209–10219.[58] PubMed | CrossRef

•. Aldhamen Y, Appledorn D, Seregin S, et al. Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens. J Immunol 2011; 186:722–732.[77] PubMed | CrossRef

•. Brichacek B, Vanpouille C, Kiselyeva Y, et al. Contrasting roles for TLR ligands in HIV-1 pathogenesis. PLoS One 2010; 5:e12831.[39] CrossRef

•. Casartelli N, Sourisseau M, Feldmann J, et al. Tetherin restricts productive HIV-1 cell-to-cell transmission. PLoS Pathog 2010; 6:e1000955.[62] PubMed | CrossRef

•. Chang J, Lindsay R, Kulkarni S, et al. Polymorphisms in interferon regulatory factor 7 reduces interferon-α responses of plasmacytoid dendritic cells to HIV-1. AIDS 2011; 25:715–717.[74] View Full Text | PubMed | CrossRef

••. Daelemans D, Dumont J, Rosenwirth B, et al. Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle. Antiviral Res 2010; 85:418–421.[47] View Full Text | PubMed | CrossRef

•. De Jong M, de Witte L, Taylor M, Geijtenbeek T. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol 2010; 185:1633–1641.[18] PubMed | CrossRef

•. Ding J, Rapista A, Teleshova N, et al. Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyan-ion microbicides. J Innate Immunol 2011; 3:208–212.[13]

Douville RN, Hiscott J. The interface between the innate interferon response and expression of host retroviral restriction factors [Review]. Cytokine 2010; 52:108–115. View Full Text | PubMed | CrossRef

•. Farrow M, Kim E, Wolinsky S, Sheehy A. NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G. J Biol Chem 2011; 286:2567–2577.[60] PubMed | CrossRef

•. Favre D, Mold J, Hunt P, et al. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2010; 2:32–36.[64]

••. Fraietta J, Mueller Y, Do D, et al. Phosphorothioate 2′ deoxyribose oligomers as microbicides that inhibit human immuno-deficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1. Antimicrob Agents Chemother 2010; 54:4064–4073.[31] PubMed | CrossRef

••. Ghosh M, Shen Z, Fahey J, et al. Trappin-2/Elafin: a novel innate antihuman immunodeficiency virus-1 molecule of the human female reproductive tract. Immunology 2010; 129:207–219.[12] View Full Text | PubMed | CrossRef

••. Gringhuis S, van der Vlist M, van den Berg L, et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 2010; 11:419–426.[32] PubMed | CrossRef

•. Hong B, Song X, Rollins L, et al. Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells. J Clin Invest 2011; 121:739–751.[45] View Full Text | PubMed | CrossRef

Iwabu Y, Kinomoto M, Tatsumi M, Fujita H, et al. Differential Anti-APOBEC3G Activity of HIV-1 Vif Proteins Derived from Different Subtypes. J Biol Chem 2010; 285:35350–35358. PubMed | CrossRef

•. Kim E, Bhattacharya T, Kunstman K, et al. Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure. J Virol 2010; 84:10402–10405.[52] PubMed | CrossRef

•. Kim K, Yolamanova M, Zirafi O, et al. Semen-mediated enhance-ment of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 2010; 7:55.[14]

Lassen KG, Wissing S, Lobritz MA, Santiago M, et al. Identification of Two APOBEC3F Splice Variants Displaying HIV-1 Antiviral Activity and Contrasting Sensitivity to Vif. J Biol Chem 2010; 285:29326–29335. PubMed | CrossRef

••. Liu X, Zhan Z, Xu L, et al. MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIalpha. J Immunol 2010; 185:7244–7251.[44]

•. Lu J, Pan Q, Rong L, et al. The IFITM proteins inhibit HIV-1 infection. J Virol 2011; 85:2126–2137.[33] PubMed | CrossRef

•. Ma J, Li X, Xu J, et al. The cellular source for APOBEC3G's incorporation into HIV-1. Retrovirology 2011; 8:2.[59] PubMed | CrossRef

••. Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214–217.[34] View Full Text | PubMed | CrossRef

••. Martinson J, Montoya C, Usuga X, et al. Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation. Antimicrob Agents Chemother 2010; 54:871–881.[66] PubMed | CrossRef

••. Melki M, Saïdi H, Dufour A, et al. Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk: a pivotal role of HMGB1. PLoS Pathog 2010; 6:e1000862.[67] PubMed | CrossRef

•. Mosoian A, Teixeira A, Burns C, et al. Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. Proc Natl Acad Sci USA 2010; 107:10178–10183.[30] PubMed | CrossRef

••. Rabi S, O'Connell K, Nikolaeva D, et al. Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection. J Virol 2011; 85:979–986.[11] PubMed | CrossRef

•. Sabado R, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839–3852.[72] PubMed | CrossRef

•. Sadler H, Stenglein M, Harris R, Mansky L. APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis. J Virol 2010; 84:7396–7404.[53] PubMed | CrossRef

•. Shah AH, Sowrirajan B, Davis ZB, et al. Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe 2010; 8:397–409.[69] PubMed

••. Shi J, Zhou J, Shah V, et al. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. J Virol 2011; 85:542–549.[48] PubMed | CrossRef

••. Singh R, Gaiha G, Werner L, et al. Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol 2011; 85:208–216.[49] PubMed | CrossRef

•. Strbo N, Vaccari M, Pahwa S, et al. Gp96(SIV)Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa. Vaccine 2011; 29:2619–2625.[78] PubMed | CrossRef

Thielen BK, McNevin JP, McElrath MJ, Hunt BVS, et al. Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms. J Biol Chem 2010; 285:27753–27766. PubMed | CrossRef

•. Vieillard V, Fausther-Bovendo H, Samri A, et al. Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers. J Acquir Defic Syndr 2010; 53:564–573.[68]

•. Yan N, Regalado-Magdos A, Stiggelbout B, et al. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010; 11:1005–1013.[35] PubMed | CrossRef

•. Zhou Y, Wang X, Liu M, et al. A critical function of toll-like receptor-3 in the induction of antihuman immunodeficiency virus activities in macrophages. Immunology 2010; 131:40–49.[37] View Full Text | PubMed

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Article Level Metrics