An introduction to Current Opinion in HIV and AIDS
David A. Coopera and Giuseppe Pantaleob
aNational Centre in HIV Epidemiology and Clinical Research, Faculty of Medicine, University of New South Wales, St Vincent's Hospital, Sydney, Australia and bDivision of Immunology and Allergy and Laboratory of AIDS Immunopathogenesis, Department of Medicine, Centre Hospitalier Vaudois, University of Lausanne, Lausanne, Switzerland
We are pleased to introduce the first issue of Current Opinion in HIV and AIDS. AIDS first grabbed the world's attention in 1981 and has continued to do so for the past twenty-five years. A vast amount of literature is published on the subject each year in a plethora of journals yet there appears to be a void in HIV and AIDS for short, concise, current reviews – this journal fills that void. Current Opinion in HIV and AIDS is part of the long-standing and well received Current Opinion series in clinical medicine and is dedicated to the review of recent advances in HIV and AIDS. This reader-friendly, broad-based resource empowers those working in the field of HIV and AIDS to put to good use vital clinical and basic science research from throughout the world. It will help clinicians and researchers keep up-to-date with the vast amount of information published in the field. The journal will publish bimonthly (in print and online) and will focus on one topic per issue, each topic being divided into clinical science and basic science sections. Each section will be developed under the guidance of internationally recognized experts who select topics and authors from around the world. This process will provide the reader with a critical review of recent publications in the field, highlighting the latest developments related to the section's theme as well as comprehensive annotated bibliographies. These contributions will be complemented with an editorial written by the section editors. In subsequent years the same section topics will continue to be updated. In addition, the section editors and editorial board will add or substitute new, emerging areas of interest in HIV and AIDS. Here we are pleased to introduce ourselves and the section editors of the first issue of Current Opinion in HIV and AIDS.
David A. Cooper
David Cooper AO, Professor of Medicine at the University of New South Wales, is Director of the National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia. The National Centre is funded by the Commonwealth Department of Health and Ageing to conduct research into the HIV/AIDS epidemic in Australia with the ultimate aim of reducing the burden of the HIV/AIDS epidemic for the affected community.
The major responsibilities of the National Centre are the epidemiology and surveillance of HIV/AIDS in Australia, including research aspects and the coordination and conduct of clinical trials of innovative therapies and vaccines for HIV disease, as well as an active clinical research program with particular emphasis on primary HIV infection and hepatitis C.
In addition to the National Centre, Professor Cooper is Head of the Immunology/HIV/Infectious Diseases Clinical Service Unit at St Vincent's Hospital, Sydney, one of the largest inpatient and outpatient services for the treatment of HIV disease in Australia. He is co-Director of the St Vincent's Hospital Medical Research groups. Professor Cooper is an author on over 390 published scientific papers and is on the editorial boards of several international journals.
Internationally, Professor Cooper is recognized as a leading HIV clinician and clinical investigator. He is a past President of the International AIDS Society. He is a Director of HIVNAT, a clinical research and trials collaboration based at the Thai Red Cross AIDS Research Centre at the Chulalongkorn University Hospital in Bangkok, Thailand. He is actively involved in studies of biomedical prevention strategies for HIV infection in the developing world including vaccines and chemoprophylaxis.
Professor Cooper is married to Dorrie and has two daughters, Rebecca and Ilana.
Professor Giuseppe Pantaleo was born June 17, 1956 in Bari, Italy. In 1980, he received the degree in medicine with full marks and honors, and in 1983, he obtained the Board in Clinical Hematology.
His scientific career in the field of immunology began in 1983 working on the development of a limiting dilution cloning system which was critical for the subsequent studies aimed at the phenotypic and functional characterization of circulating T lymphocytes. From 1985 to 1987 he was amongst the pioneers in the delineation of the molecular and biochemical mechanisms involved in signal transduction in human T lymphocytes.
In 1989, Professor Pantaleo joined the Laboratory of Immunoregulation, NIAID, NIH. He was the first to demonstrate the defective clonogenic potential of CD8+ T lymphocytes and the selective defect of HIV-specific cytotoxic T lymphocytes. He then studied the relationship between immune response and viral reservoirs in different anatomic compartments. He demonstrated that lymphoid organs function as a major reservoir for HIV, and that active virus replication occurs in lymphoid organs throughout the course of HIV disease including the prolonged period of clinical latency. These findings have completely changed the clinical and therapeutic management of HIV infection.
In the following years, he has continued to provide important contributions to the understanding the immunopathogenesis of HIV infection. Amongst these it is noteworthy to mention the delineation of the virologic and immunologic events associated with primary HIV infection, and the observation that the proportion of CD8+ T cells involved in antiviral immune response was substantially higher compared to what was previously estimated.
Since 1997 he has pioneered the field of immune-based intervention in HIV infection and he has been part of a European program for the development of a vaccine against HIV-AIDS.
Professor Pantaleo is author and co-author of about 200 publications in internationally scientific journals.
Professor Pantaleo is Professor of Medicine and Chief of the Division of Immunology and Allergy (IAL) and of the Laboratory of AIDS Immunopathogenesis at the Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.
Richard T. Davey, Jr
Richard Davey received his undergraduate degree in Life Sciences from the Massachusetts Institute of Technology in 1976 and his medical degree from the Columbia University College of Physicians and Surgeons in 1980. He completed his residency in internal medicine at Boston University Hospital in 1983 and then undertook a fellowship in Infectious Diseases in the Laboratory of Parasitology at the National Institute of Allergy and Infectious Diseases (NIAID), NIH, in Bethesda, Maryland. He joined the Laboratory of Immunoregulation (LIR), NIAID, in 1987 as a senior investigator working in the HIV research program under the mentorship of Dr. Clifford Lane. His iconoclasm was entirely self-generated, however.
Dr. Davey's major clinical research interests include the development and testing of novel antiretroviral strategies, the study of the immunopathogenesis of AIDS, and the development of immune-based therapies useful as potential adjuncts in the treatment of HIV-1 infection. He has published extensively in these areas, including particular emphasis on the early phase I and phase II testing of interleukin-2 as an immune-enhancing agent. He has been medical director of the intramural NIAID HIV research clinic since 1991, Chief of the Clinical Research Section of LIR since 2001, and NIAID Deputy Clinical Director since 2004.
Frank Miedema was born in 1954. He studied biochemistry with special major in immunology at the state university of Groningen, the Netherlands and received his PhD in 1985 from the University of Amsterdam. His thesis work was on the immunobiology of normal and malignant human T cells. From 1984 he has been involved in research on the immuno-virology of HIV infection at the Central Laboratory of the Blood Transfusion Service and the Academic Medical Center in Amsterdam as one of the project leaders of the Amsterdam Cohort Studies. In 2004 he moved his laboratory to become professor of Immunology at the University Medical Center Utrecht. He has published over 230 papers on HIV virology and immunology and has been an invited speaker at many international meetings.