Institutional members access full text with Ovid®

Share this article on:

Altered antigen-presenting cells during HIV-1 infection

Piguet, Vincenta,b; Caucheteux, Stephan M.a; Iannetta, Marcoc,d,e,f; Hosmalin, Annec,d,e,f

Current Opinion in HIV and AIDS: September 2014 - Volume 9 - Issue 5 - p 478–484
doi: 10.1097/COH.0000000000000096
CELL EXHAUSTION IN HIV-1 INFECTION: Edited by Daniel E. Kaufmann and Nabila Seddiki

Purpose of review The purpose of this study is to describe the alterations that HIV-1 induces in antigen-presenting cells (APCs), in vitro, ex vivo and in vivo.

Recent findings HIV-1 disarms several arms of the immune system including APCs. We summarize here recent findings on the impact of the virus on APC.

Summary HIV-1 can invade APC and overall reduce their capacity to present antigens effectively, mostly by reducing their numbers and inducing permanent hyperactivation. This occurs via a combination of alterations; however, the host can counteract, at least in part, some of these defects via restriction factors, autophagy, the production of type I interferon, antiviral cytokines, among others. However, these specific mechanisms of viral evasion from APCs’ control lead to a chronic hyperactivation of the immune system implicated in AIDS-related and non-AIDS related pathogenesis. Unfortunately, the current regimens of antiretroviral therapy are unable to dampen sufficiently APC-driven viral-induced immune hyperactivation. Understanding how HIV alters APC will help to tune appropriately both intrinsic immunity and innate immunity, as well as achieve efficient antigen presentation to the adaptive immune system, without inducing a detrimental pervasive hyperactivation of the immune system.

aDepartment of Dermatology and Academic Wound Healing, Institute of Infection & Immunity, Cardiff University

bWelsh Institute of Dermatology, University Hospital of Wales, Cardiff, Wales, UK

cInserm U1016, Institut Cochin

dCNRS UMR8104

eUniversity Paris Descartes

fAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Paris, France

Correspondence to Vincent Piguet, Department of Dermatology and Wound Healing, Cardiff University, Institute of Infection and Immunity, Cardiff University School of Medicine, Glamorgan house, Heath Park, Cardiff, Wales CF14 4XN, UK. E-mail: piguetv@cardiff.ac.uk

© 2014 Lippincott Williams & Wilkins, Inc.