Skip Navigation LinksHome > May 2014 - Volume 9 - Issue 3 > Immunogen design to focus the B-cell repertoire
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0000000000000054
SPECTRUM OF HIV ANTIBODIES IN VACCINE AND DISEASE: Edited by Georgia D. Tomaras and David C. Montefiori

Immunogen design to focus the B-cell repertoire

Sattentau, Quentin J.

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Purpose of review: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs).

Recent findings: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens.

Summary: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.

© 2014 Lippincott Williams & Wilkins, Inc.


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