Immunogen design to focus the B-cell repertoire

Sattentau, Quentin J.

Current Opinion in HIV & AIDS: May 2014 - Volume 9 - Issue 3 - p 217–223
doi: 10.1097/COH.0000000000000054
SPECTRUM OF HIV ANTIBODIES IN VACCINE AND DISEASE: Edited by Georgia D. Tomaras and David C. Montefiori

Purpose of review: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs).

Recent findings: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens.

Summary: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

Correspondence to Quentin J. Sattentau, PhD, Sir William Dunn School of Pathology, The University of Oxford, Oxford OX13RE, UK. Tel: +44 1865 275511; e-mail: Quentin.sattentau@path.ox.ac.uk

© 2014 Lippincott Williams & Wilkins, Inc.