The effects of untreated and treated HIV infection on bone diseaseCotter, Aoife G.a; Mallon, Patrick W.G.a , bCurrent Opinion in HIV and AIDS: January 2014 - Volume 9 - Issue 1 - p 17–26 doi: 10.1097/COH.0000000000000028 DOES ANTIRETROVIRAL TREATMENT AT HIGH CD4 COUNTS REDUCE DISEASE RISK FOR HIV-POSITIVE PATIENTS?: Edited by Jason V. Baker and Caroline A. Sabin Abstract Author Information Purpose of review Low bone mineral density (BMD) is common in those with HIV, associated with higher bone turnover and a higher prevalence of fractures. This review explores low BMD in HIV, focusing on underlying mechanisms and relationships between low BMD and HIV infection, immune dysfunction, and antiretroviral therapy (ART). Recent findings Greater reductions in BMD accompanying reductions in HIV viremia at initiation of first-line or second-line ART suggest an important role for immune- or viral-mediated mechanisms in its pathogenesis. Summary As bone metabolism is part-regulated by T cells and B cells, we propose that earlier initiation of ART at higher CD4+ T-cell counts may attenuate BMD loss by abrogating immune- and viral-mediated disturbances in bone metabolism that accompany ART initiation. Further pathogenesis-based research is required in this field, focusing on the complex interaction between virus, immune system, ART, and bone metabolism. aHIV Molecular Research Group, School of Medicine & Medical Science, University College Dublin bDepartment of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland Correspondence to Dr Aoife Cotter, Catherine McAuley Education and Research Centre, Mater Misericordiae University Hospital, Eccles St. Dublin 7, Ireland. Tel: +353 1 716 4552; fax: +353 1 716 6335; e-mail: Aoife.email@example.com © 2014 Lippincott Williams & Wilkins, Inc.