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Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0000000000000006
TREATMENT OPTIMISATION: Edited by David H. Brown Ripin, Charles W. Flexner and Ben Plumley

Reformulation of existing antiretroviral drugs

Gogtay, Jaideep A.a; Malhotra, Geenab

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Abstract

Purpose of review: In the last decade, there has been marked progress in the treatment of HIV/AIDS. Today, nearly 10 million people are receiving ART. Yet, there are several opportunities for the enhancement of current antiretroviral (ARV) drugs by developing new formulations, which could increase bioavailability, reduce pharmacokinetic variability, and reduce the total daily dose.

Recent findings: Significant developments are occurring in new formulations of ARV drugs. The introduction of once daily combination pills and combination dispersible pills for children have been important steps. Several researchers and pharmaceutical companies are using nanomedicine for improved formulations and to reduce the dose. Other novel methods include intramuscular depot formulations, vaginal gels for prevention of transmission and sprinkle formulations for children. Regulatory approval, efficacy, safety and cost–effectiveness are factors that will have to be determined for the new formulations. Collaboration between pharmaceutical companies, academic centers, funding agencies and regulatory agencies will be crucial to achieve this goal.

Summary: In this review, we describe the objectives of new formulations, recent advances including combinations, copackaged drugs, nanomedicine, pediatric products and new routes of delivery and the challenges that lie ahead.

© 2013 Lippincott Williams & Wilkins, Inc.

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