Skip Navigation LinksHome > November 2012 - Volume 7 - Issue 6 > The potential uses of preexposure prophylaxis for HIV preven...
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e328358e49e
PRE-EXPOSURE PROPHYLAXIS: Edited by Kenneth H Mayer

The potential uses of preexposure prophylaxis for HIV prevention among people who inject drugs

Baral, Stefan D.a,b; Strömdahl, Susannea,b; Beyrer, Chrisa

Collapse Box

Abstract

Purpose of review: Oral preexposure prophylaxis (PrEP) has shown HIV preventive efficacy for several key populations at risk for HIV infection including MSM and heterosexual men and women in HIV serodiscordant relationships. An efficacy trial of daily oral tenofovir among people who inject drugs (IDU) is underway in Thailand.

Recent findings: Although efficacy data is pending, there is emerging biological and public health plausibility data suggesting the utility of PrEP as an effective component of combination HIV prevention for IDU. Drawing from studies characterizing adherence to antiretroviral therapy for IDU, there are a range of scientific and operational considerations for the potential use of PrEP for IDU. We review here the available literature on the potential use of PrEP for IDU, barriers to uptake and adherence, and potential implementation science questions, which could address, and potently increase, the effectiveness of this intervention.

Summary: IDU remain the most underserved population in the HIV response worldwide, and have a marked gap in prevention services, making PrEP a potentially promising addition to the prevention toolkit for people who use drugs and, for those already living with HIV infection, for their spouses and other sexual partners.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.