Skip Navigation LinksHome > September 2012 - Volume 7 - Issue 5 > Coreceptor usage in different reservoirs
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e328356e9c2
VIRAL TROPISM: Edited by Annemarie M.J. Wensing and Rolf Kaiser

Coreceptor usage in different reservoirs

Soulie, Cathia; Calvez, Vincent; Marcelin, Anne-Geneviève

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Abstract

Purpose of review: HIV-1 infects tissue macrophages, microglia and other mononuclear phagocytes which represent an important cellular reservoir for viral replication and persistence in macrophage-rich tissue. This compartmentalization allows the virus to exist as genetically distinct quasi-species that can have capacities to use different coreceptors for cell entry. This review assesses the tropism of HIV-1 in different human compartments.

Recent findings: The majority of HIV infection occurs with R5-tropic viruses probably due to the selective expression of the R5 cell-surface protein on the target cells in the genital muscosa. There is a large concordance of tropism use between blood cell-associated proviral DNA and RNA plasma viruses, allowing the use of CC chemokine receptor 5 (CCR5) antagonists in patients who have undetectable viral load and for whom HIV tropism was determined in DNA. Most of HIV strains in central nervous system remain R5-tropic allowing the use of CCR5 antagonists.

Summary: There are many clinical situations in which the use of CCR5 antagonists can be used and several ways to determine HIV tropism in most of the compartments.

© 2012 Lippincott Williams & Wilkins, Inc.

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