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Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e32835211e9
CO-INFECTION OF POVERTY RELATED DISEASES WITH WORMS: Edited by Alison Elliott and Maria Yazdanbakhsh

Mechanisms of interaction between protozoan parasites and HIV

Andreani, Guadalupea,1; Lodge, Roberta,b,1; Richard, Davea,b; Tremblay, Michel J.a,b

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Abstract

Purpose of review: This review summarizes the current knowledge on human immunodeficiency virus type 1 (hereinafter called HIV)/protozoan co-infections in the case of three important, although neglected, tropical diseases: malaria, trypanosomiasis (Chagas disease) and leishmaniasis. The HIV pandemic has modified the immunopathogenic, epidemiological and therapeutic aspects of these human diseases.

Recent findings: In-vitro data suggests that HIV favors Leishmania infection, whereas different parasites have contrasting effects on HIV. However, many of the previous models are a limited representation of the complex interactions within the host; this situation is particularly the case when microbial products are used in place of live parasites.

Summary: In the host, protozoan parasites generally enhance HIV replication and accelerate AIDS progression. HIV alters parasite pathogenesis, often worsening disease outcome. These aspects bring significant complications for the treatment of co-infected individuals.

© 2012 Lippincott Williams & Wilkins, Inc.

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