Skip Navigation LinksHome > September 2011 - Volume 6 - Issue 5 > Innate signaling in HIV-1 infection of dendritic cells
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e328349a2d1
Innate immunity: Edited by William A. Paxton and Teunis B.H. Geijtenbeek

Innate signaling in HIV-1 infection of dendritic cells

van der Vlist, Michiel; van der Aar, Angelic M.G.; Gringhuis, Sonja I.; Geijtenbeek, Teunis B.H.

Collapse Box

Abstract

Purpose of review: This review summarizes the current knowledge of innate signaling events that are involved in HIV-1 infection. We here focus on dendritic cells, which are among the first cells that encounter HIV-1 after exposure.

Recent findings: HIV-1 triggers multiple pattern recognition receptors on dendritic cells that facilitate infection and transmission to T cells. Triggering of the C-type lectin DC-SIGN induces signals that promote HIV-1 replication in dendritic cells and transmission to T cells. Similarly, dendritic cell immunoreceptor has been shown to bind HIV-1 and facilitate transmission to T cells. The cytosolic sensors TRIM5 and cyclophilin A recognize capsid proteins and activate antiviral responses to prevent HIV-1 infection. Moreover, activation of mammalian target of rapamycin (mTOR) by HIV downregulates autophagy preventing adaptive immune responses.

Summary: Dendritic cells express an array of pattern recognition receptors that are involved in HIV-1 infection. However, HIV-1 dampens signaling by these receptors leading to suppressed responses or takes advantage of their signaling for its own benefit.

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.