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Simian immunodeficiency virus macaque models of HIV latency

Deere, Jesse Da; Schinazi, Raymond Fc; North, Thomas Wa,b

Current Opinion in HIV & AIDS: January 2011 - Volume 6 - Issue 1 - p 57–61
doi: 10.1097/COH.0b013e32834086ce
HIV reservoirs: from pathogenesis to drug development: Edited by Robert F. Siliciano and Janet D. Siliciano

Purpose of review: This review will focus on recent developments in several nonhuman primate models of AIDS. These models are being used to address viral latency and persistence during antiretroviral therapy in studies that are not feasible in humans.

Recent findings: Further characterization of the various macaque models of AIDS has demonstrated that several aspects of viral persistence during antiretroviral therapy model HIV-1 infection in humans, including viral decay kinetics. Widespread distribution of viral RNA and viral DNA has been detected in many tissue organs. In addition, the brain has been identified as a site of persistent viral DNA.

Summary: The macaque models of AIDS are well suited for addressing viral persistence during antiretroviral therapy, including viral latency, residual replication, and tissue organ distribution.

aCenter for Comparative Medicine, USA

bDepartment of Veterinary Molecular Biosciences, University of California, Davis, California, USA

cEmory University School of Medicine, Veterans Affairs Medical Center, Decatur, Georgia, USA

Correspondence to Dr Thomas W. North, Center for Comparative Medicine, University of California, Davis, CA 95616, USA Tel: +1 530 752 3414; fax: +1 530 752 7914; e-mail: twnorth@ucdavis.edu

© 2011 Lippincott Williams & Wilkins, Inc.