Skip Navigation LinksHome > January 2011 - Volume 6 - Issue 1 > Primary cell models of HIV latency
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e3283412568
HIV reservoirs: from pathogenesis to drug development: Edited by Robert F. Siliciano and Janet D. Siliciano

Primary cell models of HIV latency

Yang, Hung-Chih

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Abstract

Purpose of review: To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.

Recent findings: It has been challenging to develop a primary cell model of HIV latency that can authentically recapitulate the quiescent features of resting CD4+ T cells. Recently, several articles have described different approaches that can generate latently HIV-infected resting CD4+ T cells in vitro. Some of them further demonstrated that the primary cell models of HIV latency are suitable for biochemical studies and drug screening.

Summary: Recent progress in primary cell models of HIV latency has facilitated research on the mechanisms of HIV latency. These models also serve as a platform for the discovery of drugs that can purge the latent reservoir for HIV in resting CD4+ T cells. These studies will allow deeper insight to the mechanisms governing HIV latency and may help identify some candidate compounds for use in therapeutic strategies for the eradication of latent HIV.

© 2011 Lippincott Williams & Wilkins, Inc.

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