Skip Navigation LinksHome > November 2010 - Volume 5 - Issue 6 > What are biomarkers?
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e32833ed177
Biomarkers of outcomes of disease, treatment and complications: Edited by H. Clifford Lane and Jens D. Lundgren

What are biomarkers?

Strimbu, Kyle; Tavel, Jorge A

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Abstract

Purpose of review: This article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research.

Recent findings: The definitions of the terms discussed in this article – medical signs, symptoms, biomarkers, surrogate endpoints, clinical endpoints, validation – are still under discussion, as are their relationships to each other, but broad consensus has developed in the past decade and a half about the necessity of distinguishing between, in particular, surrogate and clinical endpoints.

Summary: This article outlines the major definitions of the key terms in this field and considers select cases in which misunderstandings about the terms led to flawed research conclusions.

© 2010 Lippincott Williams & Wilkins, Inc.

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