Skip Navigation LinksHome > July 2009 - Volume 4 - Issue 4 > Epidemiology of HIV-associated tuberculosis
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e32832c7d61
Epidemiology: Edited by Tim Mastro and Quarraisha Abdool-Karim

Epidemiology of HIV-associated tuberculosis

Lawn, Stephen Da,b; Churchyard, Gavinb,c,d

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Abstract

Purpose of review: We review literature concerning the epidemiology of HIV-associated tuberculosis (HIV-TB), focusing on articles published between 2007 and 2008.

Recent findings: An estimated 1.37 million new cases of HIV-TB occurred in 2007, representing 15% of the total global burden of TB. In addition, an estimated 456 000 HIV-TB deaths accounted for 23% of global HIV/AIDS mortality. Sub-Saharan Africa is the worst affected region with 79% of the disease burden. The epicentre of the coepidemic lies in the south of the continent, with South Africa alone accounting for over one quarter of all cases. A critical overlap between HIV and the global multidrug-resistant TB epidemics is emerging. Although it is as yet unclear whether HIV is driving a disproportionate increase in multidrug-resistant TB cases at a population level, HIV has nevertheless been a potent risk factor for institutional outbreaks, especially in South Africa and eastern Europe. Increasing data have highlighted the risk of TB among HIV-infected healthcare workers in resource-limited settings. However, many studies also show the major benefits to be derived from antiretroviral therapy in high-income and low-income countries.

Summary: HIV-TB remains a major challenge to global health that requires substantial increases in resource allocation and concerted international action.

© 2009 Lippincott Williams & Wilkins, Inc.

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