Skip Navigation LinksHome > September 2008 - Volume 3 - Issue 5 > Biology of HIV mucosal transmission
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e32830634c6
Microbicides: Edited by John Kaldor and Melissa Robbiani

Biology of HIV mucosal transmission

Wu, Li

Collapse Box

Abstract

Purpose of review: HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission.

Recent findings: New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell–cell transmission of HIV-1 mediated by the major target cells, including dendritic cells, CD4+ T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission.

Summary: Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus–host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS.

© 2008 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.