Skip Navigation LinksHome > September 2008 - Volume 3 - Issue 5 > Biology of HIV mucosal transmission
Current Opinion in HIV & AIDS:
doi: 10.1097/COH.0b013e32830634c6
Microbicides: Edited by John Kaldor and Melissa Robbiani

Biology of HIV mucosal transmission

Wu, Li

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Abstract

Purpose of review: HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission.

Recent findings: New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell–cell transmission of HIV-1 mediated by the major target cells, including dendritic cells, CD4+ T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission.

Summary: Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus–host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS.

© 2008 Lippincott Williams & Wilkins, Inc.

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