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Current Opinion in Hematology:
doi: 10.1097/MOH.0b013e3283297b87
Current World Literature: Bibliography

Current World Literature

Free Access

This bibliography is compiled by clinicians from the journals listed at the end of this publication. It is based on literature entered into our database between 1 November 2007 and 31 October 2008 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

• Papers considered by the reviewers to be of special interest

•• Papers considered by the reviewers to be of outstanding interest

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

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Myeloid disease

Differentiation therapy of acute myeloid leukemia: past, present and future

Review: (pp. 84–91)

Ahmed Z, Shaikh MA, Raval A, Mehta JB, et al. All-trans retinoic acid syndrome: Another cause of drug-induced respiratory failure. South Med J 2007; 100:899–902.

• Bug G, Schwarz K, Schoch C, et al. Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia. Haematologica 2007; 92:542–545. PubMed | CrossRef [44]

Davidovici BB, Tuzun Y, Wolf R. Retinoid receptors. Dermatol Clin 2007; 25:525–. PubMed | CrossRef

De Santis GC, De Barros M, Sousa TRB, Moreno SE, et al. Adhesion. molecules and differentiation syndrome: phenotypic and functional analysis of the effect of ATRA, AS(2)O(3), phenylbutyrate, and G-CSF in acute promyelocytic leukemia. Haematologica 2007; 92:1615–1622. PubMed | CrossRef

Drumea K, Yang ZF, Rosmarin A. Retinoic acid signaling in myelopoiesis. Curr Opin Hematol 2008; 15:37–41. View Full Text | PubMed | CrossRef

•• Fazi F, Zardo G, Gelmetti V, et al. Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood 2007; 109:4432–4440. PubMed[29]

•• Glasow A, Barrett A, Petrie K, et al. DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia. Blood 2008; 111:2374–2377. PubMed | CrossRef [30]

• Hattori H, Zhang X, Jia Y, et al. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood 2007; 110:640–650. PubMed | CrossRef [59]

Jacomo RH, Melo RAM, Souto FR, de Mattos ER, et al. Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines. Haematologica 2007; 92:1431–1432. PubMed | CrossRef

• Jepsen K, Solum D, Zhou T, et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007; 450:415–419. View Full Text | PubMed | CrossRef [32]

• Kondo Y, Shen L, Cheng AS, et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 2008; 40:741–750. PubMed | CrossRef [31]

•• Lallemand-Breitenbach V, Jeanne M, Benhenda S, et al. Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol 2008; 10:547–555.[26]

McNamara S, Wang HL, Hanna N, Miller WH. Topoisomerase II beta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance. Mol Cell Biol 2008; 28:2066–2077. PubMed | CrossRef

• Meester-Smoor MA, Janssen MJ, Grosveld GC, et al. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR induced gene expression. Carcinogenesis 2008; 29:2025–2034.[41]

Miranda MB, Redner RL, Johnson DE. Inhibition of Src family kinases enhances retinoic acid-induced gene expression and myeloid differentiation. Mol Cancer Ther 2007; 6:3081–3090. PubMed | CrossRef

Miwako I, Kagechika H. Tamibarotene. Drugs Today 2007; 43:563–568. PubMed

Mongan NP, Gudas LJ. Diverse actions of retinoid receptors in cancer prevention and treatment [Review]. Differentiation 2007; 75:853–870.

Okazuka K, Masuko M, Seki Y, Hama H, et al. Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion. Int J Hematol 2007; 86:246–249. PubMed | CrossRef

Qiu J, Huang Y, Chen G, Chen Z, et al. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell 2007; 18:3941–3951. PubMed | CrossRef

Racanicchi L, Montanucci P, Basta GPP, Pensato A, et al. Effect of all trans retinoic acid on lysosomal alpha-D-mannosidase activity in Hl-60 cell: correlation with Hl-60 cells differentiation. Mol Cell Biochem 2008; 308:17–24. View Full Text | PubMed | CrossRef

Rajpurkar M, Alcasabas P, Warrier I, Valentini RP, et al. Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure. Pediatric Blood Cancer 2007; 49:994–996. View Full Text | PubMed | CrossRef

Si JT, Mueller L, Schuler A, Simon J, et al. The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells. Blood Cells Mol Dis 2007; 39.

Soriano AO, Yang H, Faderl S, Estrov Z, et al. Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood 2007; 110:2302–2308. PubMed | CrossRef

• Soriano AO, Yang H, Faderl S, et al. Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood 2007; 110:2302–2308. PubMed | CrossRef [18]

•• Tatham MH, Geoffroy MC, Shen L, et al. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol 2008; 10:538–546. PubMed | CrossRef [25]

Valappil S, Kurkar M, Howell R. Outcome of pregnancy in women treated with all-trans retinoic acid; A case report and review of literature. Hematology 2007; 12:415–418. PubMed

• van Wely KH, Meester-Smoor MA, Janssen MJ, et al. The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription. Oncogene 2007; 26:5733–5740. View Full Text | PubMed | CrossRef [38]

• Wald DN, Vermaat HM, Zang S, et al. Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound. Cancer Res 2008; 68:4369–4376. PubMed | CrossRef [60]

Wang T, Ma XC, Krausz KW, Idle JR, et al. Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. J Pharmacol Exp Ther 2008; 324:674–684. PubMed | CrossRef

•• Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008; 111:2505–2515. PubMed | CrossRef [02]

Witcher M, Pettersson F, Dupere-Richer D, Padovani A, et al. Retinoic acid modulates chromatin to potentiate tumor necrosis factor alpha signaling on the DIF2 promoter. Nucleic Acids Res 2008; 36:435–443. View Full Text | PubMed | CrossRef

•• Zheng X, Seshire A, Ruster B, et al. Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells. Haematologica 2007; 92:323–331.[24]

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Molecular signatures in acute myeloid leukemia

Review: (pp. 64–69)

Adachi S, Manabe A, Imaizumi M, Taga T, et al. Acute myeloid leukemia with multifineage dysplasia in children. Int J Hematol 2007; 86:358–363.

Ahn JS, Yang DH, Kim YK, Cho SH, et al. Multiple intracranial tuberculomas mimicking granulocytic sarcomas in acute myeloid leukemia. J Korean Med Sci 2007; 22:S171–S173. PubMed | CrossRef

Bacher U, Haferlach C, Kern W, Haferlach T, et al. Prognostic relevance of FLT3-TKD mutations in AML: the combination matters - an analysis of 3082 patients. Blood 2008; 111:2527–2537. PubMed | CrossRef

•• Baltimore D, Boldin MP, O'Connell RM, et al. MicroRNAs: new regulators of immune cell development and function. Nat Immunol 2008; 9:839–845. PubMed | CrossRef [53]

Baran Y, Ural AU, Gunduz U. Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cells. Hematology 2007; 12:497–503.

Breccia M, Cimino G, Diverio D, Gentilini F, et al. Sustained molecular remission after low dose gemtuzumab-ozogamicin in elderly patients with advanced acute promyelocytic leukemia. Haematologica 2007; 92:1273–1274. PubMed | CrossRef

Buesche G, Ganser A, Schlegelberger B, von Neuhoff N, et al. Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia. Leukemia 2007; 21:2420–2427. View Full Text | PubMed | CrossRef

Buesche G, Teoman H, Wilczak W, Ganser A, et al. Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes. Leukemia 2008; 22:313–322. View Full Text | PubMed | CrossRef

• Bullinger L, Döhner K, Kranz R, et al. An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML. Blood 2008; 111:4490–4495. PubMed | CrossRef [25]

Buzzai M, Licht JD. New molecular concepts and targets in acute myeloid leukemia. Curr Opin Hematol 2008; 15:82–87. View Full Text | PubMed | CrossRef

Catalano A, Dawson MA, Somana K, Opat S, et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007; 110:4073–4076. PubMed | CrossRef

Cortes J, Quintas-Cardama A, Garcia-Manero G, O'Brien S, et al. Phase 1 study of tipifarnib in combination with imatinib for patients with chronic myelogenous leukemia in chronic phase after imatinib failure. Cancer 2007; 110:2000–2006. PubMed | CrossRef

Frankfurt O, Licht JD, Tallman MS. Molecular characterization of acute myeloid leukemia and its impact on treatment [Review]. Curr Opin Oncol 2007; 19:635–649. View Full Text | PubMed | CrossRef

Garzon R, Garofalo M, Martelli MP, Briesewitz R, et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA 2008; 105:3945–3950. PubMed | CrossRef

Gez S, Crossett B, Christopherson RI. Differentially expressed cytosolic proteins in human leukemia and lymphoma cell lines correlate with lineages and functions. BBA-Proteins Proteomics 2007; 1774:1173–1183.

Hatfield KJ, Hovland R, Oyan AM, Kalland KH, et al. Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels. Leukemia 2008; 22:287–293.

Hellstrom-Lindberg E, Malcovati L. Supportive care and use of hematopoietic growth factors in myelodysplastic syndromes. Semin Hematol 2008; 45:14–22. PubMed | CrossRef

Iwasaki T, Sugisaki C, Nagata K, Takagi K, et al. Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia. Pathol Int 2007; 57:645–651. View Full Text | PubMed | CrossRef

Kaune KM, Baumgart M, Gesk S, Mitteldorf C, et al. Bullous Sweet syndrome in a patient with t(9;22)(q34;q11)-positive chronic myeloid leukemia treated with the tyrosine kinase inhibitor nilotinib - Interphase cytogenetic detection of BCR-ABL-positive lesional cells. Arch Dermatol 2008; 144:361–364.

Konieczna I, Horvath E, Wang H, Lindsey S, et al. Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. J Clin Invest 2008; 118:853–867. View Full Text | PubMed

Konig H, Holyoake TL, Bhatia R. Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606. Blood 2008; 111:2329–2338. PubMed | CrossRef

Lu L, Zhang L, Xiao ZJ, Lu SH, et al. Neuropilin-1 in acute myeloid leukemia: Expression and role in proliferation and migration of leukemia cells. Leuk Lymphoma 2008; 49:331–338. PubMed | CrossRef

Lyubimova LS, Demidova IA, Ustinova EN, Gribanova EO, et al. Results of the second randomized trial of the treatment of acute promyelocytic leukemias, carried out by the Russian Research Group of hematology centers [Russian]. Gematol Transfuziol 2007; 52:3–9. PubMed

•• Marcucci G, Radmacher MD, Maharry K, et al. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008; 358:1919–1928. View Full Text | PubMed | CrossRef [08]

Markowski TR, Martin DB, Kao GF, Lutz L, et al. Leukemia cutis: A presenting sign in acute promyelocytic leukemia. Arch Dermatol 2007; 143:1220–1221. View Full Text | PubMed | CrossRef

Matsunaga T, Fukai F, Miura S, Nakane Y, et al. Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia. Leukemia 2008; 22:353–360. View Full Text | PubMed | CrossRef

Meyer LH, Queudeville M, Eckhoff SM, Creutzig U, et al. Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML. Blood 2008; 111:2899–2903. PubMed | CrossRef

Mufti G. David Galton, myelodysplasia and little me!. Leuk Lymphoma 2007; 48:2286–2287. PubMed | CrossRef

Ngo N, Summary IAL, Naresh KN. Bone marrow trephine findings in acute myeloid leukaemia with multilineage dysplasia. Br J Haematol 2008; 140:279–286.

• O'Connell RM, Rao DS, Chaudhuri AA, et al. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med 2008; 205:585–594. PubMed | CrossRef [50]

Owen C, Barnett M, Fitzgibbon J. Familial myelodysplasia and acute myeloid leukaemia - a review [Review]. Br J Haematol 2008; 140:123–132. View Full Text | PubMed

Park MH, Cho SA, Yoo KH, Yang MH, et al. Gene expression profile related to prognosis of acute myeloid leukemia. Oncol Rep 2007; 18:1395–1402. PubMed

Rajappa S, Varadpande L, Paul T, Jacob R, et al. Imatinib mesylate in early chronic phase chronic myeloid leukemia: Experience from a developing country. Leuk Lymphoma 2008; 49:554–558. PubMed | CrossRef

Rubnitz JE, Gibson B, Smith FO. Acute myeloid leukemia [Review]. Pediatr Clin North Am 2008; 55:21. PubMed | CrossRef

Runarsson G, Feltenmark S, Forsell PKA, Sjoberg J, et al. The expression of cytosolic phospholipase A(2) and biosynthesis of leukotriene B-4 in acute myeloid leukemia cells. Eur J Haematol 2007; 79:468–476. View Full Text | PubMed | CrossRef

•• Schlenk RF, Döhner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008; 358:1909–1918. View Full Text | PubMed | CrossRef [05]

Stirewalt DL, Meshinchi S, Kopecky KJ, Fan WH, et al. Identification of genes with abnormal expression changes in acute myeloid leukemia [Review]. Gene Chromosomes Cancer 2008; 47.

Suela J, Alvarez S, Cigudosa JC. DNA profiling by arrayCGH in acute myeloid leukemia and myelodysplastic syndromes. Cytogenet Genome Res 2007; 118:304–309.

Travaglino E, Benatti C, Malcovati L, Della Porta MG, et al. Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes. Eur J Haematol 2008; 80:216–226. View Full Text | PubMed | CrossRef

Uchiumi H, Matsushima T, Yamane A, Doki N, et al. Prevalence and clinical characteristics of acute myeloid leukemia associated with disseminated intravascular coagulation. Int J Hematol 2007; 86:137–142. PubMed | CrossRef

• Verhaak RGW, Wouters BJ, Erpelinck CAJ, et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica 2009; 94:131–134. PubMed | CrossRef [23]

Wang HR, Gu CH, Zhu JY, Hua JYH, et al. PNAS-2: A novel gene probably participating in leukemogenesis. Oncology (Williston Park) 2006:423–429.

•• Wouters BJ, Löwenberg B, Delwel R. A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects. Blood 2009; 113:291–298. PubMed | CrossRef [30]

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Advancements in the molecular pathogenesis of myelodysplastic syndrome

Review: (pp. 70–76)

Adeyinka A, Smoley S, Fink S, Sanchez J, et al. Isochromosome (X)(p10) in hematologic disorders: FISH study of 14 new cases show three types of centromere signal patterns. Cancer Genet Cytogenet 2007; 179:25–30. PubMed | CrossRef

Akoz AG, Engin H, Oztoprak N. Atypical presentation of retinoic acid syndrome that mimics septic arthritis in a patient with acute promyelocytic leukemia. Acta Oncol 2007; 46:1193–1194. PubMed | CrossRef

Atallah E, Garcia-Manero G. Treatment strategies in myelodysplastic syndromes [Review]. Cancer Invest 2008; 26:208–216. PubMed | CrossRef

Ban KC, Gao Y, Amin HM, Howard A, et al. BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood 2008; 111:2904–2908.

Barosi G, Mesa RA, Thiele J, Cervantes F, et al. Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the international working group for myelofibrosis research and treatment. Leukemia 2008; 22:437–438. View Full Text | PubMed | CrossRef

Boveri E, Passamonti F, Rumi E, Pietra D, et al. Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations. Br J Haematol 2008; 140:162–168. View Full Text | PubMed

Buccisano F, Maurillo L, Tamburini A, Del Poeta G, et al. Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes. Eur J Haematol 2008; 80:107–114. View Full Text | PubMed

Cervantes F, Mesa R, Barosi G. New and old treatment modalities in primary myelofibrosis. Cancer J 2007; 13:377–383. View Full Text | PubMed | CrossRef

Cortelezzi A, Gritti G, Del Papa N, Pasquini MC, et al. Pulmonary arterial hypertension in primary myelofibrosis is common and associated with an altered angiogenic status. Leukemia 2008; 22:646–649. View Full Text | PubMed | CrossRef

de The H, Zhu J, Lallemand-Breitenbach V, Guillemin MC, et al. Decrypting acute promyelocytic leukemia pathogenesis through therapy response [Spanish]. Med-Buenos Aires 2007; 67:70.

•• Ebert BL, Pretz J, Bosco J, et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 2008; 451:335–339. View Full Text | PubMed | CrossRef [20]

Economopoulou C, Pappa V, Kontsioti F, Papageorgiou S, et al. Analysis of apoptosis regulatory genes expression in the bone marrow (BM) of adult de novo Myelodysplastic Syndromes (MDS). Leuk Res 2008; 32:61–69. PubMed | CrossRef

Elliott MA, Verstovsek S, Dingli D, Schwager SM, et al. Monocytosis is an adverse prognostic factor for survival in younger patients with primary myelofibrosis. Leuk Res 2007; 31:1503–1509. PubMed | CrossRef

Falini B. Any role for the nucleophosmin (NPM1) gene in myelodysplastic syndromes and acute myeloid leukemia with chromosome 5 abnormalities? Leuk Lymphoma 2007; 48:2093–2095.

Follo MY, Finelli C, Bosi C, Martinelli G, et al. PI-PLC beta-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes. Leukemia 2008; 22:198–200. View Full Text | PubMed | CrossRef

Girrbach G. Case report - Use of iron chelate therapy for patients with myelodysplastic Syndromes (MDS) [German]. Onkologie 2007; 30:525. PubMed

Goh DH, Lee SH, Cho DC, Park SH, et al. Chronic idiopathic myelofibrosis presenting as cauda equina compression due to extramedullary hematopoiesis: A case report. J Korean Med Sci 2007; 22:1090–1093. PubMed | CrossRef

Haase D, Germing U, Schanz J, Pfeilstocker M, et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood 2007; 110:4385–4395. PubMed | CrossRef

Han Q, Sun Z, Liu LH, Chen B, et al. Impairment in immuno-modulatory function of F1k1(+)CD31(-)CD(34) MSCs from MDS-RA patients. Leuk Res 2007; 31:1469–1478. PubMed | CrossRef

Ho CL, Lasho TL, Butterfield JH, Tefferi A. Global cytokine analysis in myeloproliferative disorders. Leuk Res 2007; 31:1389–1392. PubMed | CrossRef

Jurisic V, Terzic T, Pavlovic S, Colovic N, et al. Elevated TNF-alpha and LDH without parathormone disturbance is associated with diffuse osteolytic lesions in leukemic transformation of myelofibrosis. Pathol Res Pract 2008; 204.

Kaiafa G, Papadopoulos A, Ntaios G, Saouli Z, et al. Detection of CD55- and CD59-deficient granulocytic populations in patients with myelodysplastic syndrome. Ann Hematol 2008; 87:257–262. View Full Text | PubMed | CrossRef

Kannan-Thulasiraman P, Dolniak B, Kaur S, Sassano A, et al. Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids. Biochem Biophys Res Commun 2008; 368:983–989. PubMed | CrossRef

Knoll B, Rea DJ, Szoztek J, Nagorney DS, et al. Extramedullary hematopoiesis. Am J Hematol 2008; 83:171. PubMed | CrossRef

Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, et al. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell 2008; 13:141–152. PubMed | CrossRef

Leone G, Pagano L, Ben-Yehuda D, Voso MT. Therapy-related leukemia and myelodysplasia: susceptibility and incidence. Haematologica 2007; 92:1389–1398.

Li X, Wu LY, Ying SX, Chang CK, et al. Clonality investigation of morphologically dysplastic hematopoietic cells in myelodysplastic syndrome marrows. Int J Hematol 2008; 87:176–183. PubMed | CrossRef

Ma L, Ceuppens J, Kasran A, Delforge M, et al. Immature and mature monocyte-derived dendritic cells in myelodysplastic syndromes of subtypes refractory anemia or refractory anemia with ringed sideroblasts display an altered cytokine profile. Leuk Res 2007; 31:1373–1382. PubMed | CrossRef

Ma XM, Selvin S, Raza A, Foti K, et al. Clustering in the incidence of myelodysplastic syndromes. Leuk Res 2007; 31:1683–1686. PubMed | CrossRef

Mahesh S, Ginzburg Y, Verma A. Iron overload in myelodysplastic syndromes [Review]. Leuk Lymphoma 2008; 49:427–438. PubMed | CrossRef

Malcovati L, Cazzola M. Myelodysplastic/myeloproliferative disorders. Haematologica 2008; 93:4–6.

McCarthy N. Myelodysplastic syndromes: Dia findings. Nat Rev Microbiol 2007; 7(10):726:726.

Meers S, Kasran A, Boon L, Lemmens J, et al. Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40-CD40L interactions with T helper cells. Leukemia 2007; 21:2411–2419. View Full Text | PubMed | CrossRef

Mesa RA. New insights into the pathogenesis and treatment of chronic myeloproliferative disorders. Curr Opin Hematol 2008; 15:121–126. View Full Text | PubMed | CrossRef

Mirza I, Frantz C, Clarke G, Voth AJ, et al. Transformation of polycythemia vera to chronic myelogenous leukemia. Arch Pathol Lab Med 2007; 131:1719–1724. PubMed

Mohamedali A, Gaken J, Twine NA, Ingram W, et al. Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes. Blood 2007; 110:3365–3373.

Niemeyer CM, Baumann I. Myelodysplastic syndrome in children and adolescents. Semin Hematol 2008; 45:60–70. PubMed | CrossRef

Nilsson L, Eden P, Olsson E, Mansson R, et al. The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes. Blood 2007; 110:3005–3014. PubMed | CrossRef

•• Omidvar N, Kogan S, Beurlet S, et al. BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia. Cancer Res 2007; 67:11657–11667. PubMed | CrossRef [81]

Ozbudak IH, Shilo K, Hale S, Aguilera NS, et al. Alveolar airspace and pulmonary artery involvement by extramedullary hematopoiesis - A unique manifestation of myelofibrosis. Arch Pathol Lab Med 2008; 132:99–103. PubMed

Palandri F, Iacobucci I, Martinelli G, Amabile M, et al. Long-term outcome of complete cytogenetic responders after imatinib 400 mg in late chronic phase, Philadelphia-positive chronic myeloid leukemia: The GIMEMA working party on CML. J Clin Oncol 2008; 26:106–111. PubMed | CrossRef

Papa V, Tazzari PL, Chiarini F, Cappellini A, et al. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells. Leukemia 2008; 22:147–160. View Full Text | PubMed | CrossRef

Pfeilstocker M, Karlic H, Nosslinger T, Sperr W, et al. Myelodysplastic syndromes, aging, and age: Correlations, common mechanisms, and clinical implications [Review]. Leuk Lymphoma 2007; 48:1900–1909. PubMed | CrossRef

•• Rassool FV, Gaymes TJ, Omidvar N, et al. Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia? Cancer Res 2007; 67:8762–8771.[56]

• Rollison DE, Howlader N, Smith MT, et al. Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001–2004, using data from the NAACCR and SEER programs. Blood 2008; 112:45–52.[01]

Rumi E, Passamonti F, Della Porta MG, Elena C, et al. Familial chronic myeloproliferative disorders: Clinical phenotype and evidence of disease anticipation. J Clin Oncol 2007; 25:5630–5635. PubMed | CrossRef

Sadiq SA, Rammal M, Sara G. Chronic myeloid leukemia associated with mitoxantrone treatment in a patient with MS. Multiple Sclerosis 2008; 14:272–273. PubMed | CrossRef

Saghafi M, Azarian A, Nohesara N. Primary hypertrophic osteoarthropathy with myelofibrosis. Rheumatol Int 2008; 28:597–600. PubMed | CrossRef

Samochatova EV, Moschan AA, Aleinikova OV, Bespalova AV, et al. Long-term results of combined treatment of acute promyelocytic leukemia in children and adolescents with gene therapy [Russian]. Ter Arkh 2007; 79:19–26. PubMed

Samochatova EV, Moschan AA, Aleinikova OV, Bespalova AV, et al. Long-term results of combined treatment of acute promyelocytic leukemia in children and adolescents with gene therapy [Russian]. Ter Arkh 2007; 79:26–30. PubMed

Sloand EM. Myelodysplastic syndromes: Introduction. Semin Hematol 2008; 45:1–2. PubMed | CrossRef

Sloand EM, Rezvani K. The role of the immune system in myelodysplasia: Implications for therapy [Review]. Semin Hematol 2008; 45:39–48. PubMed | CrossRef

Sokol L, List AF. Immunomodulatory therapy for myelodysplastic syndromes. Int J Hematol 2007; 86:301–305. PubMed | CrossRef

Steensma DP, Porcher JC, Hanson CA, Lathrop CL, et al. Prevalence of erythrocyte haemoglobin H inclusions in unselected patients with clonal myeloid disorders. Br J Haematol 2007; 139:439–442. View Full Text | PubMed | CrossRef

Strom SS, Velez-Bravo V, Estey EH. Epidemiology of myelodysplastic syndromes. Semin Hematol 2008; 45:8–13. PubMed | CrossRef

Tartas NE, Foncuberta MC, Avalos JCS. Treatment of hematologic neoplasms during pregnancy [Spanish]. Med-Buenos Aires 2007; 67:729–736.

Tefferi A, Thiele J, Vardiman JW. The 2008 World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: a paradigm of effective collaboration among clinicians, pathologists, and scientists. Blood 2008; 111:1742. PubMed | CrossRef

Ueda T, Ito Y, Maeda M, Fukunaga Y. Massive periosteal reaction a presenting feature of acute megakaryocytic leukemia. Pediatr Int 2007; 49:1015–1017. View Full Text | PubMed | CrossRef

van de Loosdrecht AA, Westers TM, Westra AH, Drager AM, et al. Identification of distinct prognostic subgroups in low- and intermediate-1-risk myelodysplastic syndromes by flow cytometry. Blood 2008; 111:1067–1077. PubMed | CrossRef

Varga G, Kiss J, Varkonyi J, Vas V, et al. Inappropriate notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplastic syndromes. Pathol Oncol Res 2007; 13:311–319.

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Optimal sequencing of treatments for patients with myelodysplastic syndromes

Review: (pp. 77–83)

• Alessandrino EP, Della Porta MG, Bacigalupo A, et al. WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Blood 2008; 112:895–902. PubMed | CrossRef [10]

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Ortega J, List A. Immunomodulatory drugs in the treatment of myelodysplastic syndromes [Review]. Curr Opin Oncol 2007; 19:656–659. View Full Text | PubMed | CrossRef

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Sekeres MA. New data with arsenic trioxide in leukemias and myelodysplastic syndromes. Clinical Lymphoma Myeloma 2007; 8:S7–S12. View Full Text | PubMed | CrossRef

Shimoda K, Shide K, Kamezaki K, Okamura T, et al. The effect of anabolic steroids on anemia in myelofibrosis with myeloid metaplasia: Retrospective analysis of 39 patients in japan. Int J Hematol 2007; 85:338–343. PubMed | CrossRef

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Novel strategies for patients with chronic myeloproliferative disorders

Review: (pp. 129–134)

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Labussiere H, Hayette S, Tigaud I, Michallet M, et al. Treatment of chronic myeloid leukemia in 2007 [Review] [French]. Bull Cancer (Paris) 2007; 94:863–869.

• Mesa RA, Camoriano JK, Geyer SM, et al. A phase II trial of tipifarnib in myelofibrosis: primary, postpolycythemia vera and postessential thrombocythemia. Leukemia 2007; 21:1964–1970.[25]

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• Quintás-Cardama A, Tong W, Kantarjian H, et al. A phase II study of 5-azacitidine for patients with primary and postessential thrombocythemia/polycythemia vera myelofibrosis. Leukemia 2008; 22:965–970.[36]

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Sessions J. Chronic myeloid leukemia in 2007. J Manag Care Pharm 2007; 13:S4–S7. PubMed

• Tefferi A, Lasho TL, Mesa RA, et al. Lenalidomide therapy in del(5)(q31)-associated myelofibrosis: cytogenetic and JAK2V617F molecular remissions. Leukemia 2007; 21:1827–1828. View Full Text | PubMed | CrossRef [39]

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Allogeneic hematopoietic cell transplantation for patients with myelofibrosis

Review: (pp. 140–146)

• Bacigalupo A, Dominietto A, Pozzi S, et al. Allogeneic hemopoietic stem transplant for patient with idiopathic myelofibrosis using a reduced intensity based conditioning regimen [abstract #684]. Blood 110(Part 1); 2007:210a.[25]

•• Barosi G, Bergamaschi G, Marchetti M, et al. JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood 2007; 110:4030–4036. PubMed | CrossRef [32]

• Elliott MA, Verstovsek S, Dingli D, et al. Monocytosis is an adverse prognostic factor for survival in younger patients with primary myelofibrosis. Leuk Res 2007; 31:1503–1509. PubMed | CrossRef [43]

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Kroger N, Thiele E, Zander A, Schwerdtfeger R, et al. Rapid regression of bone marrow fibrosis after dose-reduced allogeneic stem cell transplantation in patients with primary myelofibrosis. Exp Hematol 2007; 35:1719–1722.

•• Kroger N, Thiele J, Zander A, et al. Rapid regression of bone marrow fibrosis after dose-reduced allogeneic stem cell transplantation in patients with primary myelofibrosis. Exp Hematol 2007; 35:1719–1722.[39]

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Impact of new prognostic markers in treatment decisions in acute myeloid leukemia

Review: (pp. 98–104)

Ades L, Sanz MA, Chevret S, Montesinos P, et al. Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results. Blood 2008; 111:1078–1084. PubMed | CrossRef

Armand P, Kim HT, Cutler CS, Ho VT, et al. A prognostic score for patients with acute leukemia or myelodysplastic syndromes undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2008; 14:28–35.

• Büchner T, Berdel WE, Kienast J, et al. Cytogenetically normal acute myeloid leukemia. N Engl J Med 2008; 359:651–653. View Full Text | PubMed | CrossRef [34]

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• Brown P, McIntyre E, Rau R, et al. The incidence and clinical significance of nucleophosmin mutations in childhood AML. Blood 2007; 110:979–985. PubMed | CrossRef [24]

• Falini B, Nicoletti I, Martelli MF, et al. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc_ AML): biological and clinical features. Blood 2007; 109:874–885.[16]

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• Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111:2776–2784. PubMed | CrossRef [23]

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• Marcucci G, Maharry K, Radmacher MD, et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol 2008; 26:5078–5087. PubMed | CrossRef [48]

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• Whitman SP, Ruppert AS, Marcucci G, et al. Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study. Blood 2007; 109:5164–5167. PubMed | CrossRef [52]

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Novel postremission strategies in adults with acute myeloid leukemia

Review: (pp. 105–111)

Amadori S, Stasi R. Integration of monoclonal antibodies and immunoconjugates into the treatment of acute myeloid leukemia. Curr Opin Hematol 2008; 15:95–100. View Full Text | PubMed | CrossRef

Burnett AK, Kell J. Tipifarnib in acute myeloid leukemia. Drugs Today 2007; 43:795–800. PubMed

Colado E, Alvarez-Fernandez S, Maiso P, Martin-Sanchez J, et al. The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34(+) immature phenotype. Haematologica 2008; 93:57–66. PubMed | CrossRef

Eom KS, Kim HJ, Min WS, Lee S, et al. Gemtuzumab ozogamicin in combination with attenuated doses of standard induction chemotherapy can successfully induce complete remission without increasing toxicity in patients with acute myeloid leukemia aged 55 or older. Eur J Haematol 2007; 79:398–404.

• Grovdal M, Khan R, Aggerholm A, et al. Maintenance treatment with azacytidine for patients with high risk myelodysplastic syndromes or acute myeloid leukaemia in complete remission after intensive chemotherapy [abstract no. 818]. ASH Annual Meeting Abstracts 2007: 110.[56]

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Jurcic JG. Ab therapy of AML: native anti-CD33 Ab and drug conjugates [Review]. Cytotherapy 2008; 10:7–12.

• Karp JE, Smith BD, Gojo I, et al. Phase II trial of tipifarnib as maintenance therapy in first complete remission in adults with acute myelogenous leukemia and poor-risk features. Clin Cancer Res 2008; 14:3077–3082. PubMed[57]

Lofgren C, Lehmann S, Jonsson-Videsater K, Mollgard L, et al. Higher plasma but not intracellular concentrations after infusion with liposomal daunorubicin compared with conventional daunorubicin in adult acute myeloid leukemia. Ther Drug Monit 2007; 29:626–631. View Full Text | PubMed | CrossRef

Mato AR, Morgans A, Luger SM. Novel strategies for relapsed and refractory acute myeloid leukemia. Curr Opin Hematol 2008; 15:108–114. View Full Text | PubMed | CrossRef

Miyawaki S, Kawai Y, Takeshita A, Komatsu N, et al. Phase I trial of FLAGM with high doses of cytosine arabinoside for relapsed, refractory acute myeloid leukemia: Study of the Japan Adult Leukemia Study Group (JALSG). Int J Hematol 2007; 86:343–347. PubMed | CrossRef

•• Qazilbash MH, Wieder ED, Thall PF, et al. PR1 peptide vaccine-induced immune response is associated with better event-free survival in patients with myeloid leukemia [abstract no. 283]. ASH Annual Meeting Abstracts 2007: 110.[64]

Raponi M, Lancet JE, Fan HT, Dossey L, et al. A 2-gene classifier for predicting response to the famesyltransferase inhibitor tipifarnib in acute myeloid leukemia. Blood 2008; 111:2589–2596.

Sugita J, Tanaka J, Kurosawa M, Fukuhara T, et al. Effects of the mean daily doses of imatinib during the first year on survival of patients with chronic myeloid leukemia in Japan: a study of the Hokkaido Hematology Study Group. Eur J Haematol 2008; 80:160–163. View Full Text | PubMed

White D, Saunders V, Grigg A, Arthur C, et al. Measurement of in vivo BCR-ABL kinase inhibition to monitor imatinib-induced target blockade and predict response in chronic myeloid leukemia. J Clin Oncol 2007; 25:4445–4451. PubMed | CrossRef

Yamamoto K, Emi N, Kajiguchi T, Yamamori S, et al. Eosinophils derived from acute promyelocytic leukemia cells after arsenic trioxide treatment. Int J Hematol 2007; 85:456–457. PubMed | CrossRef

•• Zeng Z, Shi YX, Samudio IJ, et al. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 2008. http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2008-05-158311v1. [Epub ahead of print][36]

Zhang WG, Wang FX, Chen YX, Cao XM, et al. Combination chemotherapy homoharringtonine, and granulocyte in patients with with low-dose cytarabine, colony-stimulating factor priming relapsed or refractory acute myeloid leukemia. Am J Hematol 2008; 83:185–188. PubMed | CrossRef

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Appropriate sequencing of tyrosine kinase inhibitors in chronic myelogenous leukemia: when to change? A perspective in 2009

Review: (pp. 135–139)

Bao F, Polk P, Nordberg ML, Veillon DM, et al. Comparative gene expression analysis of a chronic myelogenous leukemia c-ell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res 2007; 31:1511–1520. PubMed | CrossRef

Busuttil DP. Prolonged imatinib-induced myelosuppression in chronic myeloid leukaemia with an unusually long survival. Int J Lab Hematol 2008; 30:68–70. PubMed

• De Lavallade H, Punnialingam S, Milojkovic D, et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol 2008; 141:745–747. View Full Text | PubMed | CrossRef [14]

Deenik W, van der Holt B, Verhoef GEG, Smit WM, et al. Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia. Blood 2008; 111:2581–2588. PubMed | CrossRef

Goldman JM. How I treat chronic myeloid leukemia in the imatinib era. Blood 2007; 110:2828–2837. PubMed | CrossRef

Hochhaus A, Druker B, Sawyers C, Guilhot F, et al. Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-alpha treatment. Blood 2008; 111:1039–1043. PubMed | CrossRef

• Hughes TP, Branford S, White DL, et al. Impact of early dose intensity on cytogenetic and molecular responses in chronic-phase CML patients receiving 600 mg/day of imatinib as initial therapy. Blood 2008; 112:3965–3973. PubMed | CrossRef [04]

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Jin LH, Tabe Y, Konoplev S, Xu YY, et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther 2008; 7:48–58. PubMed | CrossRef

• Kantarjian H, Pasquini R, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase-II trial. Blood 2007; 109:5143–5150.[10]

• Kantarjian HM, Giles F, Gattermann N, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007; 110:3540–3546.[13]

Kim AS, Goldstein SC, Luger S, Van Deerlin VM, et al. Sudden extramedullary T-lymphoblastic blast crisis in chronic myelogenous leukemia - A nonrandom event associated with imatinib? Am J Clin Pathol 2008; 129:639–648.

Kim PS, Lee PP, Levy D. Modeling imatinib-treated chronic myelogenous leukemia: Reducing the complexity of agent-based models. Bull Math Biol 2008; 70:728–744. PubMed | CrossRef

le Coutre P, Ottmann OG, Giles F, Kim DW, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia. Blood 2008; 111:1834–1839.

•• Marin D, Milojkovic D, Olavarria E, et al. European Leukemia Net criteria for failure or sub-optimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 2008; 112:4437–4444.[09]

Marshall HM, Hammond JM. Treatment options in imatinib-resistant chronic myelogenous leukemia. Ann Pharmacother 2008; 42:259–264. PubMed | CrossRef

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Mayerhofer M, Gleixner KV, Mayerhofer J, Hoermann G, et al. Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood 2008; 111:2200–2210. PubMed | CrossRef

Maziarz RT. Who with chronic myelogenous leukemia to transplant in the era of tyrosine kinase inhibitors? Curr Opin Hematol 2008; 15:127–133.

Nakayama S, Nagamura-Inoue T, Yokoyama K, Ohno N, et al. Cytogenetic remissions induced by interferon alpha and imatinib mesylate are immunologically distinct in chronic myeloid leukemia. Int J Hematol 2007; 86:208–211. PubMed | CrossRef

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Piccaluga PP, Malagola M, Rondoni M, Arpinati M, et al. Imatinib mesylate in the treatment of newly diagnosed or refractory/resistant c-KIT positive acute myeloid leukemia. Results of an Italian multicentric phase II study. Haematologica 2007; 92:1721–1722. PubMed | CrossRef

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Sahay T, Schiffer CA. Monitoring minimal residual disease in patients with chronic myeloid leukemia after treatment with tyrosine kinase inhibitors. Curr Opin Hematol 2008; 15:134–139. View Full Text | PubMed | CrossRef

• Shah NP, Kantarjian HM, Kim D-W, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol 2008; 26:3204–3212.[16]

Stromskaya TP, Rybalkina EY, Kruglov SS, Zabotina TN, et al. Role of P-glycoprotein in evolution of populations of chronic myeloid leukemia cells treated with imatinib. Biochem-Moscow 2008:29–37.

Yu ZA, Lomaia EG, Vinogradova OY, Druzhkoea GA, et al. Prognosis factors in imatinib mesilate therapy in patients with a chronic phase of Ph-positive chronic myeloid leukemia: Data from a multicenter non-randomized trial in Russia [Russian]. Ter Arkh 2007; 79:17–22. PubMed

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Umbilical cord blood transplantation for acute myeloid leukemia

Review: (pp. 124–128)

• Arora M, Nagaraj S, Wagner JE, et al. Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation: higher response rates in recipients of unrelated donor (URD) umbilical cord blood (UCB). Biol Blood and Marrow Transplant 2007; 13:1145–1152.[13]

•• Komanduri KV, St John LS, de Lima M, et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T cell skewing. Blood 2007; 110:4543–4551.[14]

• Liao C, Wu JY, Xu ZP, et al. Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant. Bone Marrow Transplant 2007; 40:201–208. View Full Text | PubMed | CrossRef [04]

• Lu X, Kondo Y, Takmatsu H, et al. CD16+CD56− NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect. Eur J Haematol 2008; 81:18–25. View Full Text | PubMed | CrossRef [12]

Maeda T, Shiozawa E, Mayumi H, Usui T, et al. Histopathology of bone marrow reconstitution after umbilical cord blood transplantation for hematological diseases. Pathol Int 2008; 58:126–132. View Full Text | PubMed | CrossRef

•• Majhail NS, Brunstein CG, Tomblyn M, et al. Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor. Biol Blood Marrow Transplant 2008; 14:282–289. PubMed | CrossRef [09]

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•• Terakura S, Azuma E, Murata M, et al. Hematopoietic engraftment in recipients of unrelated donor umbilical cord blood is affected by the CD34+ and CD8+ cell doses. Biol of Blood and Marrow Transplant 2007; 13:822–830.[20]

Tse WW, Zang SL, Bunting KD, Laughlin MJ. Umbilical cord blood transplantation in adult myeloid leukemia [Review]. Bone Marrow Transplant 2008; 41:465–472. View Full Text | PubMed | CrossRef

Valcarcel D, Martino R. Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and acute myelogenous leukemia [Review]. Curr Opin Oncol 2007; 19:660–666. View Full Text | PubMed | CrossRef

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Vaccination as a therapeutic strategy in acute myeloid leukemia

Schmitt M, Schmitt A, Rojewski MT, Chen JF, et al. RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses. Blood 2008; 111:1357–1365. PubMed | CrossRef

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Core binding factor acute myeloid leukemia (CBF-AML): is high-dose Ara-C (HDAC) consolidation as effective as you think?

Review: (pp. 92–97)

•• Bullinger L, Rücker FG, Kurz S, et al. Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. Blood 2007; 110:1291–1300. PubMed | CrossRef [64]

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• Gorin N-C, Labopin M, Frassoni F, et al. Identical outcome after autologous or allogeneic genoidentical hematopoietic stem-cell transplantation in first remission of acute myelocytic leukemia carrying inversion 16 or t(8;21): a retrospective study from the European Cooperative Group for Blood and Marrow Transplantation. J Clin Oncol 2008; 26:3183–3188. PubMed | CrossRef [32]

•• Jongen-Lavrencic M, Sun SM, Dijkstra MK, et al. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 2008; 111:5078–5085. PubMed | CrossRef [66]

• Narimatsu H, Iino M, Ichihashi T, et al. Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan. Int J Hematol 2008; 88:154–158. doi: 10.1007/s12185-008-0108-1.[74]

•• Paschka P, Radmacher MD, Marcucci G, et al. Gene expression profiling improves outcome prediction in adult core binding factor (CBF) acute myeloid leukemia (AML): a Cancer and Leukemia Group B (CALGB) study. J Clin Oncol 2007; 25:359a.[65]

Shide K, Shimoda HK, Kumano T, Karube K, et al. Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia 2008; 22:87–95. View Full Text | PubMed

• Weisser M, Haferlach C, Hiddemann W, Schnittger S. The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factors. Leukemia 2007; 21:1177–1182. View Full Text | PubMed | CrossRef [73]

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Second hematopoietic stem cell transplantation in myeloid malignancies

Review: (pp. 112–123)

• Frassoni F, Gualandi F, Podestà M, et al. Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study. Lancet Oncol 2008; 9:831–839. PubMed | CrossRef [18]

• Heinzelmann F, Lang PJ, Ottinger H, et al. Immunosuppressive total lymphoid radiation-based reconditioning regimens enable engraftment after graft rejection or graft failure in patients treated with allogeneic hematopoietic stem cell transplantation. Int J Radiat Oncol Biol Phys 2008; 70:523–528. PubMed | CrossRef [10]

•• Liesveld JL, Rothberg PG. Mixed chimerism in SCT: conflict or peaceful coexistence? Bone Marrow Transplant 2008; 42:297–310.[02]

Mielcarek M, Storer BE, Flowers MED, Storb R, et al. Outcomes among patients with recurrent high-risk hematologic malignancies after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2007; 13:1160–1168. PubMed | CrossRef

• Reich-Zeliger S, Bachar-Lustig E, Bar-Ilan A, Reisner Y. Tolerance induction in presensitized bone marrow recipients by veto CTLs: effective deletion of host antidonor memory effector cells. J Immunol 2007; 179:6389–6394. PubMed[37]

• Tse WW, Zang SL, Bunting KD, Laughlin MJ. Umbilical cord blood transplantation in adult myeloid leukemia. Bone Marrow Transplant 2008; 41:465–472. View Full Text | PubMed | CrossRef [13]

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Novel mutants leading to myeloid disease

Chaligne R, James C, Tonetti C, Besancenot R, et al. Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis. Blood 2007; 110:3735–3743. PubMed | CrossRef

Cortes J, Jabbour E, Kantarjian H, Yin CC, et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007; 110:4005–4011. PubMed | CrossRef

Falini B, Mecucci C, Saglio G, Lo Coco F, et al. NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica 2008; 93:439–442. PubMed | CrossRef

Gale RE, Green C, Allen C, Mead AJ, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111:2776–2784. PubMed | CrossRef

Kawamura M, Kaku H, Taketani T, Taki T, et al. Mutations of GATA1, FLT3, MLL-partial tandem duplication, NRAS, and RUNX1 genes are not found in a 7-year-old Down syndrome patient with acute myeloid leukemia (FAB-M2) having a good prognosis. Cancer Genet Cytogenet 2008; 180:74–78. PubMed | CrossRef

Majumdar S, Mondal BC, Ghosh M, Dey S, et al. Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia. Eur J Cancer Prev 2008; 17:125–132. View Full Text | PubMed | CrossRef

Mead AJ, Linch DC, Hills RK, Wheatley K, et al. FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia. Blood 2007; 110:1262–1270. PubMed | CrossRef

O'Hare T, Eide CA, Deininger MWN. Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 2007; 110:2242–2249. PubMed | CrossRef

Palmisano M, Grafone T, Ottaviani E, Testoni N, et al. NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia. Haematologica 2007; 92:1268–1269. PubMed | CrossRef

Pappa V, Papageorgiou S, Kontsioti F, Papageorgiou E, et al. Analysis of FLT3 gene mutations in de novo myelodysplastic syndromes. FLT3 internal tandem duplication detected in a case of refractory anemia. Leuk Lymphoma 2007; 48:2437–2440. PubMed | CrossRef

Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH. Genetics of therapy-related myelodysplasia and acute myeloid leukemia [Review]. Leukemia 2008; 22:240–248. View Full Text | PubMed | CrossRef

Scholl S, Melle C, Bleul A, Spies-Weisshart B, et al. Specific pattern of protein expression in acute myeloid leukemia harboring FLT3-ITD mutations. Leuk Lymphoma 2007; 48:2418–2423. PubMed | CrossRef

Shih LY, Liang DC, Huang CF, Chang YT, et al. Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples. Leukemia 2008; 22:303–307. View Full Text | PubMed | CrossRef

Shiseki M, Kitagawa Y, Wang YH, Yoshinaga K, et al. Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities. Leuk Lymphoma 2007; 48:2141–2144. PubMed | CrossRef

Su YC, Chen CB, Chang YT, Tung YT, et al. hSNF5/INI1 mutation analysis in acute myeloid leukemia. Int J Hematol 2008; 87:172–175.

Suzuki R, Onizuka M, Kojima M, Shimada M, et al. Prognostic significance of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia in an unselected patient population. Int J Hematol 2007; 86:422–428. PubMed | CrossRef

Yan LZ, Chen SN, Liang JY, Feng YF, et al. Analysis of NPM1 gene mutations in Chinese adults with acute myeloid leukemia. Int J Hematol 2007; 86:143–146. PubMed | CrossRef

Zhang WG, Konopleva M, Shi YX, McQueen T, et al. Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst 2008; 100:184–198. View Full Text | PubMed | CrossRef

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Recent advances in therapeutics

Andrieux J, Roche-Lestienne C, Geffroy S, Desterke C, et al. Bone morphogenetic protein antagonist gene NOG is involved in myeloproliferative disease associated with myelofibrosis. Cancer Genet Cytogenet 2007; 178:11–16. PubMed | CrossRef

Arsenic compound improves survival in acute promyelocytic leukemia patients. Oncology (Williston Park) 2007:1254.

Au WY, Tam S, Kwong YL. Entry of elemental arsenic into the central nervous system in patients with acute promyelocytic leukemia during arsenic trioxide treatment. Leuk Res 2008; 32:357–358. PubMed | CrossRef

Bartolini G, Orlandi M, Papi A, Ammar K, et al. Growth inhibition and proapoptotic activity induction by IIF and valproic acid on RA-resistant leukemia cells. Anticancer Res 2008; 28:283–288. PubMed

Bornhauser BC, Bonapace L, Lindhol M D, Martinez R, et al. Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway. Blood 2007; 110:2084–2091. PubMed | CrossRef

Copland M, Pellicano F, Richmond L, Allan EK, et al. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood 2008; 111:2843–2853. PubMed | CrossRef

Czuczman MS, Emmanouilides C, Darif M, Witzig TE, et al. Treatment-related Myelodysplastic syndrome and acute myelogenous leukemia in patients treated with ibritumomab tiuxetan radioimmunotherapy. J Clin Oncol 2007; 25:4285–4292. PubMed | CrossRef

Damaj G, Bernit E, Ghez D, Claisse JF, et al. Thalidomide in advanced mastocytosis. Br J Haematol 2008; 141:249–253. View Full Text | PubMed | CrossRef

Faderl S, Gandhi V, Kantarjian HM. Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia. Curr Opin Hematol 2008; 15:101–107. View Full Text | PubMed | CrossRef

Frankel A, Liu JS, Rizzieri D, Hogge D. Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia. Leuk Lymphoma 2008; 49:543–553.

Fuhler GM, Drayer AL, Olthof SGM, Schuringa JJ, et al. Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell-derived factor-1-induced migration of CD34(+) cells from patients with myelodysplasia. Blood 2008; 111:359–368. PubMed | CrossRef

Gil L, Styczynski J, Dytfeld D, Debski R, et al. Activity of bortezomib in adult de novo and relapsed acute myeloid leukemia. Anticancer Res 2007; 27:4021–4025. PubMed

Gleissner B, Schlenk R, Bornhauser M, Berdel WE. Gemtuzumab ozogamicin (mylotarg) for the treatment of acute myeloid leukemia - Ongoing trials [Review]. Onkologie 2007; 30:657–NIL_1. View Full Text | PubMed | CrossRef

Huang XF, Luo SK, Xu J, Li J, et al. Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood 2008; 111:2854–2865. PubMed | CrossRef

Illmer T, Ehninger G. FLT3 kinase inhibitors in the management of acute myeloid leukemia. Clinical Lymphoma Myeloma 2007; 8:S24–S34. View Full Text | PubMed | CrossRef

Ito Y, Ohyashiki K, Yoshida I, Takeuchi M, et al. The prophylactic effect of Itraconazole capsules and Fluconazole capsules for systemic fungal infections in patients with acute myeloid leukemia and myelodysplastic syndromes: A Japanese multicenter randomized, controlled study. Int J Hematol 2007; 85:121–127. PubMed | CrossRef

King ME, Rowe JM. Recent developments in acute myelogenous leukemia therapy. Oncologist 2007; 12:14–21.

Knipp S, Gattermann N, Schapira M, Kaferstein H, et al. Arsenic in the cerebrospinal fluid of a patient receiving arsenic trioxide for relapsed acute promyelocytic leukemia with CNS involvement. Leuk Res 2007; 31:1585–1587.

Koseki M, Asada N, Uryu H, Takeuchi M, et al. Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis. Int J Hematol 2007; 86:403–406. PubMed | CrossRef

Liao YF, Hung HC, Hour TC, Hsu PC, et al. Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Sci 2008; 82:367–375.

Meyer PN, Roychowdhury S, Kini AR, Alkan S. HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells. Leuk Res 2008; 32:143–149. PubMed | CrossRef

Mi YC, Xue YP, Yu WJ, Liu SH, et al. Therapeutic experience of adult acute myeloid leukemia in a single institution of China and its relationship with chromosome karyotype. Leuk Lymphoma 2008; 49:524–530. PubMed | CrossRef

Park JA, Yun JH, Kang HI, Shin HY, et al. Acute intestinal pseudo-obstruction after induction treatment of relapsed acute promyelocytic leukemia with arsenic trioxide. Pediatric Blood Cancer 2008; 50:872–874. PubMed | CrossRef

Petersdorf SH, Rankin C, Head DR, Terebelo HR, et al. Phase II evaluation of an intensified induction therapy with standard daunomycin and cytarabine followed by high dose cytarabine for adults with previously untreated acute myeloid leukemia: A southwest oncology group study (SWOG-9500). Am J Hematol 2007; 82:1056–1062. PubMed | CrossRef

Ravandi F, Burnett AK, Agura ED, Kantarjian HM. Progress in the treatment of acute myeloid leukemia [Review]. Cancer 2007; 110:1900–1910. PubMed | CrossRef

Rickles FR, Falanga A, Montesinos P, Sanz MA, et al. Bleeding and thrombosis in acute leukemia: What does the future of therapy look like? Thromb Res 2007; 120:S99–S106.

Rizzo JD, Somerfield MR, Hagerty KL, Seidenfeld J, et al. Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Hematology American Society of Clinical Oncology clinical practice guideline update [Review]. Blood 2008; 111:25–41.

Royer PJ, Bougras G, Ebstein F, Leveque L, et al. Efficient monocyte-derived dendritic cell generation in patients with acute myeloid leukemia after chemotherapy treatment: Application to active immunotherapy. Exp Hematol 2008; 36:329–339.

Saraiya B, Gounder M, Dutta J, Saleem A, et al. Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia. Anticancer Drug 2008; 19:411–420.

Seo T, Urasaki Y, Ueda T. Establishment of an arsenic trioxide-resistant human leukemia cell line that shows multidrug resistance. Int J Hematol 2007; 85:26–31. PubMed | CrossRef

Shachaf CM, Perez OD, Youssef S, Fan AC, et al. Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood 2007; 110:2674–2684. PubMed | CrossRef

Steinberg M. Dasatinib: A tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia [Review]. Clin Ther 2007; 29:2289–2308. PubMed | CrossRef

Suzuki K, Ohishi K, Sekine T, Masuya M, et al. Selective blast cell reduction in elderly patients with acute myeloid leukemia secondary to Myelodysplastic syndrome treated with methylprednisolone. Int J Hematol 2007; 85:344–349. PubMed | CrossRef

Thery JC, Jardin F, Massy N, Massy J, et al. Optical neuropathy possibly related to arsenic during acute promyelocytic leukemia treatment. Leuk Lymphoma 2008; 49:168–170. PubMed | CrossRef

Usuki K, Urabe A, Ikeda Y, Ohashi Y, et al. A Multicenter randomized, double-blind, placebo-controlled late-phase II/III study of recombinant human interleukin 11 in acute myelogenous leukemia. Int J Hematol 2007; 85:59–69. PubMed | CrossRef

Vasconcelos FC, Gattass CR, Rumjanek VM, Maia RC. Pomolic acid-induced apoptosis in cells from patients with chronic myeloid leukemia exhibiting different drug resistance profile. Invest New Drugs 2007; 25:525–533. View Full Text | PubMed | CrossRef

Wang GP, Qi ZH, Chen FP. Treatment of acute myeloid leukemia by directly targeting both leukemia stem cells and oncogenic molecule with specific scFv-immunolipoplexes as a deliverer. Med Hypotheses 2008; 70:122–127. PubMed | CrossRef

Wei L, Zhu YS, Guo M, Yu Y, et al. Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia. Leuk Res 2007; 31:1565–1574. PubMed | CrossRef

Weidenaar AC, de Jonge HJM, Fidler V, ter Elst A, et al. Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death. Anticancer Drug 2008; 19:45–54.

Yeh TC, Liu HC, Wang LY, Chen SH, et al. The development of a novel protocol for the treatment of de novo childhood acute myeloid leukemia in a single institution in Taiwan. J Pediatr Hematol Oncol 2007; 29:826–831. View Full Text | PubMed | CrossRef

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Chromosomal aberrations in myeloid disease

Abdulhaq H, Rossetti JM. The role of azacitidine in the treatment of myelodysplastic syndromes. Expert Opin Investig Drugs 2007; 16:1967–1975. PubMed | CrossRef

Al-Achkar W, Wafa A, Nweder MS. A complex translocation t(5;9;22) in Philadelphia cells involving the short arm of chromosome 5 in a case of chronic myelogenous leukemia. J Exp Clin Cancer Res 2007; 26:411–415. PubMed

Alfaro R, Perez-Granero A, Duran MA, Besalduch J, et al. Dup(1)(q21q32) as a sole cytogenetic event is associated to a leukemic transformation in Myelodysplastic Syndromes. Leuk Res 2008; 32:159–161. PubMed | CrossRef

Barlogie B, Tricot G, Haessler J, van Rhee F, et al. Cytogenetically defined myelodysplasia after melphalan-based autotransplantation for multiple myeloma linked to poor hematopoietic stem-cell mobilization: the Arkansas experience in more than 3000 patients treated since 1989. Blood 2008; 111:94–100. PubMed | CrossRef

Bishton M, Kenealy M, Johnstone R, Rasheed W, et al. Epigenetic targets in hematological malignancies: Combination therapies with HDACis and demethylating agents [Review]. Expert Rev Anticancer Ther 2007; 7:1439–1449. View Full Text | PubMed | CrossRef

Bussaglia E, Guardia R, Nomdedeu JF. A large exon 6 break in V-form acute promyelocytic leukemia: relevance to clinical management. Leukemia 2007; 21:2356–2357. View Full Text | PubMed | CrossRef

Chen CC, Gau JP, Yu YB, Lu CH, et al. Prognosis and treatment outcome in patients with acute myeloid leukemia with t(8;21)(q22;q22). Adv Ther 2007; 24:907–920. View Full Text | PubMed | CrossRef

De Roos AJ, Deeg HJ, Davis S. A population-based study of survival in patients with secondary myelodysplastic syndromes (MDS): impact of type and treatment of primary cancers. Cancer Causes Control 2007; 18:1199–1208. PubMed

Dicker F, Haferlach C, Kern W, Haferlach T, et al. Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia. Blood 2007; 110:1308–1316. PubMed | CrossRef

Eun B, Lee Y, Hong S, Kim J, et al. Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body. J Biol Chem 2008; 283:5939–5949. PubMed | CrossRef

Evers C, Beier M, Poelitz A, Hildebrandt B, et al. Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGH. Gene Chromosomes Cancer 2007; 46.

Gondek LP, Haddad AS, O'Keefe CL, Tiu R, et al. Detection of cryptic chromosomal lesions including acquired segmental uniparental disomy in advanced and low-risk myelodysplastic syndromes. Exp Hematol 2007; 35:1728–1738. PubMed | CrossRef

Guidez F, Parks S, Wong HN, Jovanovic JV, et al. RAR alpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia. Proc Natl Acad Sci USA 2007; 104:18694–18699. PubMed | CrossRef

Helias C, Struski S, Gervais C, Leymarie V, et al. Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2. Cancer Genet Cytogenet 2008; 180:51–55. PubMed | CrossRef

Horikoshi A, Takei K, Hosokawa Y, Sawada S. The value of oral cytarabine ocfosfate and etoposide in the treatment of refractory and elderly AML patients. Int J Hematol 2008; 87:118–125. PubMed | CrossRef

Ishikawa M, Yagasaki F, Okamura D, Maeda T, et al. A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia. Int J Hematol 2007; 86:238–245. PubMed | CrossRef

Ismail S, Ababneh N, Awidi A. Identification of atypical PML-RARA breakpoint in a patient with acute promyelocytic leukemia. Acta Haematol 2007; 118:183–187. PubMed | CrossRef

Kaune KM, Baumgart M, Gesk S, Mitteldorf C, et al. Bullous Sweet syndrome in a patient with t(9;22)(q34;q11)-positive chronic myeloid leukemia treated with the tyrosine kinase inhibitor nilotinib - Interphase cytogenetic detection of BCR-ABL-positive lesional cells. Arch Dermatol 2008; 144:361–364.

Kelaidi C, Eclache V, Fenaux P. The role of lenalidomide in the management of myelodysplasia with del 5q [Review]. Br J Haematol 2008; 140:267–278. View Full Text | PubMed | CrossRef

Kreil S, Pfirrmann M, Haferlach C, Waghorn K, et al. Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia. Blood 2007; 110:1283–1290. PubMed | CrossRef

Lee J, Lu X, Shin ES, Kern WF, et al. A novel subtelomeric translocation t(5;9) and a deletion of the RB1 gene in a patient with acute myeloid leukemia (AML-M0). Cancer Genet Cytogenet 2008; 181:36–39. PubMed | CrossRef

Li SG. Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia [Review]. Leuk Lymphoma 2008; 49:19–26. PubMed | CrossRef

Maserati E, Pressato B, Valli R, Patitucci F, et al. Constitutional trisomy 8 mosaicism in primary myelofibrosis: relevance to clinical practice and warning for trisomy 8 studies. Cancer Genet Cytogenet 2007; 179:79–81. PubMed | CrossRef

Oren H, Yilmaz S, Sercan Z, Demircioglu F, et al. Isolated myelosarcoma development in an adolescent chronic myeloid leukemia patient with t(9;22)(q34;q11.2),+8,+14,+21, and der(1)(p36). Cancer Genet Cytogenet 2008; 182:43–45. PubMed | CrossRef

Pidala J, Pinilla-Ibarz J, Cualing HD. A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet 2008; 182:46–49. PubMed | CrossRef

Sevilla J, Fernandez-Plaza S, Lassaletta A, Gonzalez-Vicent M, et al. Early acute myeloblastic leukemia treatment for childhood myelodysplastic syndrome with t(3;5) (NPM/MLF1). J Pediatr Hematol Oncol 2007; 29:839–840. View Full Text | PubMed | CrossRef

Snijder S, Mellink CHM, van der Lelie H. Translocation (2;11)(q37;q23) in therapy-related myelodysplastic syndrome after treatment for acute promyelocytic leukemia. Cancer Genet Cytogenet 2008; 180:149–152. PubMed | CrossRef

Stavropoulou C, Georgakakos VN, Manola KN, Pagoni M, et al. 5 ' RARA submicroscopic deletion from new variant translocation involving chromosomes 15, 17, and 18, in a case of acute promyelocytic leukemia. Cancer Genet Cytogenet 2008; 182:50–55. PubMed | CrossRef

Stubbs MC, Kim YM, Krivtsov AV, Wright RD, et al. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment. Leukemia 2008; 22:66–77. View Full Text | PubMed | CrossRef

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Transcriptional regulation in leukaemia

Duechler M, Stanczyk M, Czyz M, Stepnik M. Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells. Cancer Chemother Pharmacol 2008; 61:727–737. PubMed | CrossRef

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Mutations in JAK2

Barosi G, Bergamaschi G, Marchetti M, Vannucchi AM, et al. JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood 2007; 110:4030–4036. PubMed | CrossRef

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Pardanani A. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials [Review]. Leukemia 2008; 22:23–30. View Full Text | PubMed | CrossRef

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Transplantation, transfusion and graft versus host disease

Abdelkefi A, Torjman L, Ladeb S, Sghaier Z, et al. Isolated extramedullary relapse in the breast of a patient with acute myeloid leukemia following allogeneic stem cell transplantation: Case report and review of the literature [Review]. Int J Hematol 2007; 85:149–153. PubMed | CrossRef

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Kim HJ, Choi Y, Min WS, Kim TG, et al. The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia. Transplantation 2007; 84:1082–1091. View Full Text | PubMed | CrossRef

Kohno A, Morishita Y, Iida H, Yanada M, et al. Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission: a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group. Int J Hematol 2008; 87:210–216. PubMed | CrossRef

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Massa FS, Rolon JM, Pavlovsky S. Myelofibrosis with myeloid metaplasia in a patient with relapsed Hodgkin's lymphoma who underwent autologous hematopoietic stem cell transplantation. Hematology 2007; 12:487–488. PubMed

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Pulini S, D'Amico E, Basilico R, Mereu M, et al. Portal venous thrombosis in a young patient with idiopathic myelofibrosis and intrahepatic extramedullary hematopoiesis: a difficult diagnosis, prognosis and management. Leukemia 2007; 21:2373–2375. View Full Text | PubMed | CrossRef

Quiroga V, Xicoy B, Ruiz-Xivillea N, Tapia G. Coexistence of hepatosplenic myeloid metaplasia of donor's cells and graft versus host liver disease in a recipient of an allogenic transplant of hematopoietic progenitors due to idiopathic myelofibrosis [Spanish]. Med Clin (Barc) 2008; 130:197.

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Shenoy S, Smith FO. Hematopoietic stem cell transplantation for childhood malignancies of myeloid origin [Review]. Bone Marrow Transplant 2008; 41:141–148. View Full Text | PubMed | CrossRef

Siebolts U, Thiele J, Zander T, Ditschkowski M, et al. Differences in proportion and dynamics of recipient hematopoiesis following hematopoietic cell transplantation in CML and IMF. Oncol Rep 2008; 19:287–292. PubMed

Sierra J, Martino R, Sanchez B, Pinana JL, et al. Hematopoietic transplantation from adult unrelated donors as treatment for acute myeloid leukemia [Review]. Bone Marrow Transplant 2008; 41:425–437. View Full Text | PubMed | CrossRef

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Valcarel D, Martino R, Caballero D, Martin J, et al. Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: Chronic graft-versus-host disease is the strongest factor improving survival. J Clin Oncol 2008; 26:577–584.

Wang Y, Wu DP, Sun AN, Jin ZM, et al. Allogeneic hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in second chronic phase attained by imatinib after onset of blast crisis. Int J Hematol 2008; 87:167–171. PubMed | CrossRef

Wodarz D. Stem cell regulation and the development of blast crisis in chronic myeloid leukemia: Implications for the outcome of Imatinib treatment and discontinuation. Med Hypotheses 2008; 70:128–136. PubMed | CrossRef

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New developments in diagnosis, prognosis and risk factors

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