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Polyphosphate: a new player in the field of hemostasis

Smith, Stephanie A.; Morrissey, James H.

Current Opinion in Hematology:
doi: 10.1097/MOH.0000000000000069
HEMOSTASIS AND THROMBOSIS: Edited by Joseph E. Italiano and Jorge A. Di Paola
Abstract

Purpose of review: Polyphosphate (polyP) is an inorganic polymer that has recently been shown to be secreted by activated platelets. It is a potent modulator of the blood clotting and complement systems in hemostasis, thrombosis, and inflammation.

Recent findings: This review focuses on what is currently known about which blood cells secrete polyP, and the roles that polyP plays in modulating the blood clotting and complement systems in health and disease.

Summary: PolyP is a novel player in normal hemostasis and likely plays roles in thrombotic diseases and also in host responses to pathogens. It is also potentially a drug target, as its contributions to hemostasis appear to be to accelerate blood clotting but are not required for blood clotting to happen.

Author Information

Biochemistry Department, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Correspondence to James H. Morrissey, PhD, Biochemistry Department, University of Illinois at Urbana-Champaign, 323 Roger Adams Laboratory, MC-712, 600 S. Mathews Ave., Urbana, IL 61801, USA. Tel: +1 217 265 4036; e-mail: jhmorris@illinois.edu

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins