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Mechanisms of trauma-induced coagulopathy

Cardenas, Jessica C.; Wade, Charles E.; Holcomb, John B.

doi: 10.1097/MOH.0000000000000063
HEMOSTASIS AND THROMBOSIS: Edited by Joseph E. Italiano and Jorge A. Di Paola
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Purpose of review Hemorrhage is the leading cause of potentially preventable death following injury. Excessive and uncontrolled bleeding, commonly referred to as trauma-induced coagulopathy (TIC), affects a quarter of all trauma patients and is associated with substantial injuries, increased transfusion requirements, and poor outcomes. Recent data have contributed to our current understanding of the molecular mechanisms driving TIC.

Recent findings The current literature offers evidence supporting proposed mechanisms that induce TIC, such as platelet dysfunction, endogenous anticoagulation, endothelial activation, fibrinogen modifications, and hyperfibrinolysis. However, the majority of these data are mere associations; causative data are slowly unfolding through the utilization of animal models of hemorrhagic shock coupled with prospective observational clinical studies.

Summary As both clinical and basic science research expands our understanding of TIC, trauma patient care is improving substantially. Future studies should focus on the interplay between the coagulation pathways whose simultaneous or codependent dysregulation could offer the most advantageous points for intervention.

Department of Surgery, The Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA

Correspondence to Jessica C. Cardenas, PhD, 6431 Fannin Street, MSB 5.030, Department of Surgery, The Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Tel: +1 713 500 7439; fax: +1 713 500 0685; e-mail: Jessica.C.Cardenas@uth.tmc.edu

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