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Current Opinion in Hematology:
doi: 10.1097/MOH.0000000000000054
HEMATOPOIESIS: Edited by Hal E. Broxmeyer

MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia

Song, Su Jung; Pandolfi, Pier Paolo

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Abstract

Purpose of review

This review highlights recent insights into the roles of microRNAs (miRNAs) in pathogenesis of myeloid malignancies and tantalising prospects of miRNA therapy.

Recent findings

New roles for miRNAs in biological and disease processes are constantly being discovered. Although great effort has been put into identifying and cataloguing aberrantly expressed miRNAs in leukaemia, very little is known about the functional consequences of their deregulation in myeloid malignancies. This review will discuss the significance of powerful oncogenic miRNAs such as miR-22 in self-renewal and transformation of haematopoietic stem cells, as well as their ability to induce epigenetic alterations in the pathogenesis of the stem cell disorder myelodysplastic syndromes and myeloid leukaemia.

Summary

Improved understanding of biological roles of miRNAs in the pathogenesis of haematological malignancies will allow rational stratification of patients and provide new therapeutic entries for the treatment of myelodysplastic syndromes and leukaemia.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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