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Current Opinion in Hematology:
doi: 10.1097/MOH.0b013e3283500a92
MYELOID DISEASE: Edited by Martin S. Tallman

New induction and postinduction strategies in acute myeloid leukemia

Burnett, Alan K.

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Abstract

Purpose of review: Improving or replacing the traditional induction (3 + 7) and consolidation (high-dose cytarabine; Ara-C) as the standard of care for acute myeloid leukemia (AML) has proved disappointing.

Recent findings: Recent studies have raised the possibility that daunorubicin dose escalation might have the potential to improve survival. Antibody-directed therapy by means of gemtuzumab ozogamicin as an adjunct to induction chemotherapy may yet be a viable option in older patients, and alternative nucleoside analogues in induction could help higher risk subgroups. In consolidation, the number of courses and dose level of Ara-C required are being clarified. New treatments for older patients who will not be subjected to conventional chemotherapy are an active area, but randomized trials have not yet usurped low-dose Ara-C (LDAC).

Summary: Recent information in these areas is reviewed.

© 2012 Lippincott Williams & Wilkins, Inc.

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