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Endoscopic mucosal resection and endoscopic submucosal dissection: technique and new directions

Nishizawa, Toshihiroa,b; Yahagi, Naohisaa

Current Opinion in Gastroenterology: September 2017 - Volume 33 - Issue 5 - p 315–319
doi: 10.1097/MOG.0000000000000388
ENDOSCOPY: Edited by Anthony Kalloo

Purpose of review Most of small tumours in gastrointestinal tract are easily removed by endoscopic mucosal resection (EMR). However, EMR are sometimes not reliable to ensure the complete resection for large tumours. Although endoscopic submucosal dissection (ESD) was developed, it had a higher risk for complications such as perforation and bleeding. The techniques and clinical outcomes of EMR and ESD are reviewed.

Recent findings ESD is more effective for early gastric and oesophageal cancer with higher en-bloc resection rate and lower local recurrence in comparison to EMR. Several studies report favourable long-term outcomes of ESD. ESD has become a standard technique in Japan and other East Asian countries. Piecemeal resection using EMR technique is widely accepted for colorectal large adenomas and results in good clinical outcomes in most patients. However, apparent cancerous lesions need endoscopic en-bloc resection by ESD.

Summary Further development of the technique, devices and training systems will promote worldwide standardization of ESD.

aDivision of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine

bDivision of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

Correspondence to Naohisa Yahagi, MD, PhD, Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Tel: +81 3 5363 3437; fax: +81 3 5363 3895; e-mail: yahagi.keio@gmail.com

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