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Peptic ulcer disease

Louw, Japie A

Current Opinion in Gastroenterology: November 2006 - Volume 22 - Issue 6 - p 607–611
doi: 10.1097/01.mog.0000245532.12648.aa
Stomach and duodenum

Purpose of review: This review attempts to contextualize some of the clinically important publications of the last 2 years as they relate to the broad topic of dyspepsia and peptic ulcer disease, both Helicobacter pylori and nonsteroidal anti-inflammatory drug-related.

Recent findings: This review includes findings which provide insight with regard to the triaging of dyspeptic subjects, information on new proton pump inhibitor drugs and H. pylori eradication ‘rescue regimens’. The ‘COX-2 debacle’ is discussed and new data relating to the efficacy of co-therapy strategies for the prevention of nonsteroidal anti-inflammatory drug gastropathy are presented, while the use of antiplatelet agents as ‘safe’ substitutes for aspirin cardioprophylaxis is questioned. The important issue of proton pump inhibitor safety and nonsteroidal anti-inflammatory drug enteropathy are addressed.

Summary: The review provides a summary and interpretation of literature pertaining to the above issues, and should provide a point of departure for clinical decision-making relevant to these issues.

Division of Gastroenterology, Queen's University/Hotel Dieu Hospital, Kingston, Ontario, Canada

Correspondence to J. A. Louw, MBChB, MMed, FCP(SA), PhD, FRCPC, Division of Gastroenterology, Queen's University/Hotel Dieu Hospital, Kingston, ON, Canada E-mail:

© 2006 Lippincott Williams & Wilkins, Inc.