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Current Opinion in Endocrinology, Diabetes & Obesity:
doi: 10.1097/MED.0000000000000029
GROWTH AND DEVELOPMENT: Edited by Lynne L. Levitsky

Update on endocrine and metabolic therapy-related late effects observed in survivors of childhood neoplasia

Chemaitilly, Wassima,b; Hudson, Melissa M.b,c

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Purpose of review: To provide a summary of the most recent research pertaining to the endocrine and metabolic complications observed in childhood cancer survivors.

Recent findings: Data on prevalence and risk associations are increasingly available from large cohorts of childhood cancer survivors. New directions in research include novel risk-prediction strategies and the study of genetic predisposition.

Summary: Endocrine complications are observed in more than 50% of adult childhood cancer survivors. Some continue to develop decades following cancer treatment exposures. The present review provides a summary of the most recent outcomes research pertaining to growth, thyroid, gonadal–reproductive, bone and body composition with emphasis on new directions and challenges in each area.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins


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