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Selenium and the thyroid

Köhrle, Josef

Current Opinion in Endocrinology, Diabetes and Obesity: October 2013 - Volume 20 - Issue 5 - p 441–448
doi: 10.1097/01.med.0000433066.24541.88
THYROID: Edited by Lewis E. Braverman and Angela M. Leung

Purpose of review To provide information on the role of the essential trace element selenium, which enables appropriate thyroid hormone synthesis, secretion, and metabolism, and to discuss supplementation with various selenium compounds, which prevent thyroid diseases such as goiter and exert beneficial effects in thyroid autoimmune diseases.

Recent findings Selenium administration in both autoimmune thyroiditis (M. Hashimoto) and mild Graves’ disease improves clinical scores and well-being of patients and reduces autoimmune antibody titres in several prospective, placebo-controlled supplementation studies.

Summary Adequate nutritional supply of selenium, together with the two other essential trace elements iodine and iron, is required for a healthy thyroid during development and adolescence, as well as in the adult and aging populations.

Institute of Experimental Endocrinology, Charité University Medicine Berlin, Germany

Correspondence to Josef Köhrle, Institute of Experimental Endocrinology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Tel: +49 30 450 524022; e-mail: josef.koehrle@charite.de

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins