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Scavenger receptor class B type 1 gene polymorphisms and female fertility

Christianson, Mindy S.; Yates, Melissa

Current Opinion in Endocrinology, Diabetes & Obesity:
doi: 10.1097/MED.0b013e3283505771
LIPIDS: Edited by Annabelle Rodriguez
Abstract

Purpose of review: Multiple studies have demonstrated a role for scavenger receptor class B type 1 (SR-B1) in female fertility. Recent studies have implicated specific SR-B1 gene polymorphisms in decreased progesterone production and suboptimal fertility outcomes.

Recent findings: The lipoprotein receptor SR-B1 has been known to mediate selective uptake of lipids into steroidogenic tissues such as the ovaries. SR-B1 plays a major role in the ability of the corpus luteum to produce progesterone, which is known to play a key role in sustaining early pregnancy. Animal studies have demonstrated that deficiency in SR-B1 results in subfertility that can be restored with addition of SR-B1 function. Single-nucleotide polymorphisms in SCARB1, the gene encoding SR-B1, have been associated with human lipid levels. Women undergoing infertility treatment with low SR-B1 expression in granulosa cells were noted to have plasma estradiol levels half the normal levels and a significantly lower number of retrieved oocytes. In vitro, deficiency of SR-B1 is associated with lower progesterone secretion in human granulosa cells. Certain SR-B1 polymorphisms have been associated with lower follicular progesterone levels and a significantly lower clinical pregnancy rate.

Summary: Deficiency of SR-B1, particularly due to single-nucleotide polymorphisms, could explain some features of female human infertility.

Author Information

Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Lutherville, Maryland, USA

Correspondence to Melissa Yates, MD, Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 10751 Falls Road, Suite #280, Lutherville, MD 20193, USA. Tel: +1 410 583 2750; fax: +1 410 583 2767; e-mail: myates2@jhmi.edu

© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins