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Proresolving lipid mediators and diabetic wound healing

Hellmann, Jasona; Tang, Yunana; Spite, Matthewa,b

Current Opinion in Endocrinology, Diabetes and Obesity: April 2012 - Volume 19 - Issue 2 - p 104–108
doi: 10.1097/MED.0b013e3283514e00
LIPIDS: Edited by Annabelle Rodriguez

Purpose of review Defective wound healing is one of the most prominent clinical manifestations of both type 1 and type 2 diabetes. As the global rates of diabetes increase, a detailed understanding of the molecular and cellular defects that give rise to unresolved inflammation and delayed wound healing in diabetes is urgently required. Emerging evidence indicates that timely resolution of inflammation is mediated in part by endogenous proresolving lipid mediators, such as resolvins. Here, we review recent advances in the area of resolution and diabetes and highlight the potential of novel proresolving strategies for promoting wound healing in diabetes.

Recent findings Macrophage dysfunction is a critical underlying feature of altered wound healing in diabetic patients. This is associated with defective clearance of apoptotic cells, increased risk of infection, and altered angiogenesis. Diabetes and obesity are associated with chronic inflammation and altered biosynthesis of bioactive lipid mediators that promote the resolution of inflammation. Stimulating resolution with proresolving lipid mediators improves metabolic parameters in diabetes, blunts systemic inflammation, restores defective macrophage phagocytosis, and accelerates wound healing in animal models of obesity and diabetes.

Summary Stimulating resolution with proresolving lipid mediators may represent a novel strategy for promoting wound healing in diabetes.

aDivision of Cardiovascular Medicine, Diabetes and Obesity Center

bDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, USA

Correspondence to Matthew Spite, PhD, 580 S Preston Street, Room 404F, Delia Baxter Building, University of Louisville, Louisville, KY 40202, USA. Tel: +1 502 852 7215; fax: +1 502 852 3663; e-mail: Matthew.spite@louisville.edu

© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins