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Current Opinion in Critical Care:
doi: 10.1097/MCC.0b013e328360ec51

Is there a role for adrenaline during cardiopulmonary resuscitation?

Nolan, Jerry P.a; Perkins, Gavin D.b

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Purpose of review: To critically evaluate the recent data on the influence adrenaline has on outcome from cardiopulmonary resuscitation.

Recent findings: Two prospective controlled trials in out-of-hospital cardiac arrest (OHCA) have indicated that adrenaline increases the rate of return of spontaneous circulation (ROSC), but neither was sufficiently powered to determine the long-term outcomes. Several observational studies document higher ROSC rates in patients receiving adrenaline after OHCA, but these also document an association between receiving adrenaline and worse long-term outcomes.

Summary: Appropriately powered prospective, placebo-controlled trials of adrenaline in cardiac arrest are essential if the role of this drug is to be defined reliably.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins


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