Skip Navigation LinksHome > January 2013 - Volume 16 - Issue 1 > Current World Literature
Text sizing:
A
A
A
Current Opinion in Clinical Nutrition & Metabolic Care:
doi: 10.1097/MCO.0b013e32835c445e
CURRENT WORLD LITERATURE: Bibliography

Current World Literature

Free Access

This bibliography is compiled by clinicians from the relevant journals scanned by this publication. It is based on the literature regularly pulled into our database from OvidSP (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

▪ Papers considered by the reviewers to be of special interest

▪▪ Papers considered by the reviewers to be of outstanding interest

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

Back to Top | Article Outline
Ageing: biology and nutrition
Sex hormones and sarcopenia in older persons

Review: (pp. 3–13)

▪. Baker WL, Karan S, Kenny AM. Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review. J Am Geriatr Soc 2011; 59:997–1002. [14]

▪. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2012 [Epub ahead of print]. [35]

▪▪. Bhasin S, Travison TG, Storer TW, et al. Effect of testosterone supplementation with and without a dual 5(-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial. J Am Med Assoc 2012; 307:931–939. [33]

Brotto M. Aging, sarcopenia and store-operated calcium entry A common link? Cell Cycle 2011; 10:4201–4202.

Candow DG. Sarcopenia: current theories and the potential beneficial effect of creatine application strategies. Biogerontology 2011; 12:273–281. PubMed | CrossRef

Cederholm TE, Bauer JM, Boirie Y, Schneider SM, et al. Toward a Definition of Sarcopenia. Clin Geriatr Med 2011; 27:341. PubMed | CrossRef

▪▪. Dubois V, Laurent M, Boonen S, et al. Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions. Cell Mol Life Sci 2012; 69:1651–1667. [10]

Giannoulis MG, Martin FC, Nair KS, Umpleby AM, et al. Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones? Endocr Rev 2012; 33:314–377.

▪▪. Grossmann MJ. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab 2011; 96:2341–2353. [12]

Jackson JR, Ryan MJ, Alway SE. Long-Term Supplementation With Resveratrol Alleviates Oxidative Stress but Does Not Attenuate Sarcopenia in Aged Mice. J Gerontol Ser A-Biol Sci Med Sci 2011; 66:751–764.

▪. Maggio M, Nicolini F, Cattabiani C, et al. Effects of testosterone supplementation on clinical and rehabilitative outcomes in older men undergoing on-pump CABG. Contemp Clin Trials 2012; 33:730–738 [42]

▪. Maggio M, Ceda GP, Lauretani F, et al. Gonadal status and physical performance in older men. Aging Male 2011; 14:42–47. [27]

▪. Maggio M, Ceda GP, Lauretani F, et al. Magnesium and anabolic hormones in older men. Int J Androl 2011; 34:e594–e600. [37]

Morley JE. Sarcopenia in the elderly. Fam Pr 2012; 29:i44–i48.

Ogawa K, Kim HK, Shimizu T, Abe S, et al. Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people. Cell Stress Chaperones 2012; 17:349–359. PubMed | CrossRef

▪. Piantadosi C, Visvanathan R, Naganathan V, et al. The effect of testosterone and a nutritional supplement on hospital admissions in under-nourished, older people. BMC Geriatr 2011; 11:66. [39]

Rosenberg IH. Sarcopenia: Origins and Clinical Relevance. Clin Geriatr Med 2011; 27:337. PubMed | CrossRef

▪. Sakuma K, Yamaguchi A. Sarcopenia and age-related endocrine function. Int J Endocrinol 2012; 127362. [04]

▪▪. Sheffield-Moore M, Dillon EL, Casperson SL, et al. A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men. J Clin Endocrinol Metab 2011; 96:E1831–E1837. [34]

▪▪. Travison TG, Basaria S, Storer TW, et al. Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation. J Gerontol A Biol Sci Med Sci 2011; 66:1090–1099. [23]

Visser M, Schaap LA. Consequences of Sarcopenia. Clin Geriatr Med 2011; 27:387. PubMed | CrossRef

Walrand S, Guillet C, Salles J, Cano N, et al. Physiopathological Mechanism of Sarcopenia. Clin Geriatr Med 2011; 27:365. PubMed | CrossRef

Back to Top | Article Outline
Inflamm-ageing

Review: (pp. 14–20)

Addison O, La Stayo PC, Dibble LE, Marcus RL. Inflammation, Aging, and Adiposity: Implications for Physical Therapists. J Geriatr Phys Ther 2012; 35:86–94. View Full Text | PubMed | CrossRef

▪▪. Biagi E, Candela M, Fairweather-Tait S, et al. Aging of the human metaorganism: the microbial counterpart. Age 2012; 34:247–267. [37]

▪. Bonafè M, Storci G, Franceschi C. Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example: Breakdown of the multishell cytokine network fuels cancer in aged people. Bioessays 2011; 34:40–49. [27]

Capettini LSA, Montecucco F, Mach F, Stergiopulos N, et al. Role of Renin-Angiotensin System in Inflammation, Immunity and Aging. Curr Pharm Design 2012; 18: 963–970.

Chang SS, Weiss CO, Xue QL, Fried LP. Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) I and II. Arch Gerontol Geriatr 2011; 54:9–15.

▪. Claesson MJ, Jeffery IB, Conde S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 2012; 488:178–184. [34]

▪. Gregor MF, Hotamisligil GkS. Inflammatory mechanisms in obesity. Ann Rev Immunol 2011; 29:415–445. [29]

Kim JM, Uehara Y, Choi YJ, Ha YM, et al. Mechanism of attenuation of pro-inflammatory Ang II-induced NF-kappa B activation by genistein in the kidneys of male rats during aging. Biogerontology 2011; 12:537–550. PubMed | CrossRef

Lepperdinger G. Inflammation and mesenchymal stem cell aging. Curr Opin Immunol 2011; 23:518–524. PubMed | CrossRef

Lu J, Wu DM, Zheng YL, Hu B, et al. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and I kappa B kinase beta/nuclear factor-kappa B-mediated inflammatory pathways in mice. Brain Behav Immun 2011; 25:1658–1667.

Muller-Delp JM, Gurovich AN, Christou DD, Leeuwenburgh C. Redox Balance in the Aging Microcirculation: New Friends, New Foes, and New Clinical Directions. Microcirculation 2012; 19:19–28.

Njemini R, Smitz J, Demanet C, Sosso M, et al. Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition. Arch Gerontol Geriatr 2011; 53:359–363. PubMed | CrossRef

▪. Olivieri F, Lazzarini R, Recchioni R, et al. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr) 2012; [Epub ahead of print] PubMed PMID:22692818. [19]

Perlstein TS, Pande R, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011; 117:2800–2806.

▪▪. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547–556. [10]

Song Y, Shen H, Schenten D, Shan PY, et al. Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol 2012; 32:103. View Full Text | PubMed | CrossRef

▪▪. Tieri P, Termanini A, Bellavista E, et al. Charting the NF-κB pathway interactome map. PLoS One 2012; 7:e32678. [09]

▪. Vrieze A, van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012; 143:913–916. [42]

Zhou RH, Vendrov AE, Tchivilev I, Niu XL, et al. Mitochondrial Oxidative Stress in Aortic Stiffening With Age The Role of Smooth Muscle Cell Function. Arterioscler Thromb Vasc Biol 2012; 32:745. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Aging and muscle: a neuron's perspective

Review: (pp. 21–26)

Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, et al. Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging. Cell Metab 2011; 14:196–207. PubMed

Basile G, Paffumi I, D'Angelo AG, Figliomeni P, et al. Healthy centenarians show high levels of circulating interleukin-22 (IL-22). Arch Gerontol Geriatr 2012; 54:459–461. PubMed | CrossRef

Bautmans I, Vantieghem S, Gorus E, Grazzini YR, et al. Age-related differences in pre-movement antagonist muscle co-activation and reaction-time performance. Exp Gerontol 2011; 46:637–642. View Full Text | PubMed

Bori Z, Zhao ZF, Koltai E, Fatouros IG, et al. The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. Exp Gerontol 2012; 47:417–424. View Full Text | PubMed | CrossRef

Buford TW, Cooke MB, Shelmadine BD, Hudson GM, et al. Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function. Aging Clin Exp Res 2011; 23:170–174. PubMed | CrossRef

Chen YT, Neto OP, Marzullo ACD, Kennedy DM, et al. Age-associated impairement in endpoint accuracy of goal-directed contractions performed with two fingers is due to altered activation of the synergistic muscles. Exp Gerontol 2012; 47:519–526. View Full Text | PubMed | CrossRef

▪▪. Comley LH, Fuller HR, Wishart TM, et al. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Hum Mol Genet 2011; 20:2406–2421. [48]

Conroy MB, Kwoh CK, Krishnan E, Nevitt MC, et al. Muscle strength, mass, and quality in older men and women with knee osteoarthritis. Arthritis Care Res 2012; 64:15–21. PubMed | CrossRef

De Roia G, Pogliaghi S, Adami A, Papadopoulou C, et al. Effects of priming exercise on the speed of adjustment of muscle oxidative metabolism at the onset of moderate-intensity step transitions in older adults. Am J Physiol-Regul Integr Comp Physiol 2012; 302:R1158–R1166. PubMed | CrossRef

▪. Deschenes MR, Roby MA, Glass EK. Aging influences adaptations of the neuromuscular junction to endurance training. Neuroscience 2011. [53]

▪. Deschenes MR. Motor Unit and Neuromuscular Junction Remodeling with Aging. Curr Aging Sci, 2011. [49]

Dillon EL, Casperson SL, Durham WJ, Randolph KM, et al. Muscle protein metabolism responds similarly to exogenous amino acids in healthy younger and older adults during NO-induced hyperemia. Am J Physiol-Regul Integr Comp Physiol 2011; 301:R1408–R1417. PubMed | CrossRef

Faure C, Raynaud-Simon A, Ferry A, Dauge V, et al. Leucine and citrulline modulate muscle function in malnourished aged rats. Amino Acids 2012; 42:1425–1433. PubMed | CrossRef

Ferretti R, Pertille A, Neto HS, Marques MJ. AGE-RELATED CHANGES IN DYSTROPHIN-GLYCOPROTEIN COMPLEX AND IN UTROPHIN ARE NOT CORRELATED WITH INTRINSIC LARYNGEAL MUSCLES PROTECTION IN mdx MICE. Muscle Nerve 2011; 44:978–980. View Full Text | PubMed | CrossRef

Fort AT. State of the Art in Anti-Aging Trends. Clin Geriatr Med 2011; 27:507. PubMed | CrossRef

Garcia LA, King KK, Ferrini MG, Norris KC, et al. 1,25(OH)(2)Vitamin D-3 Stimulates Myogenic Differentiation by Inhibiting Cell Proliferation and Modulating the Expression of Promyogenic Growth Factors and Myostatin in C2C12 Skeletal Muscle Cells. Endocrinology 2011; 152:2976–2986. View Full Text | PubMed | CrossRef

Groen BBL, Res PT, Pennings B, Hertle E, et al. Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men. Am J Physiol-Endocrinol Metab 2012; 302:E52–E60.

Hao YL, Jackson JR, Wang Y, Edens N, et al. beta-Hydroxy-beta-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. Am J Physiol-Regul Integr Comp Physiol 2011; 301:R701–R715.

Hasson CJ, Caldwell GE. Effects of Age on Mechanical Properties of Dorsiflexor and Plantarflexor Muscles. Ann Biomed Eng 2012; 40:1088–1101. PubMed | CrossRef

Hiroki E, Abe S, Iwanuma O, Sakiyama K, et al. A comparative study of myostatin, follistatin and decorin expression in muscle of different origin. Anat Sci Int 2011; 86:151–159. PubMed | CrossRef

Jackson MJ. Control of Reactive Oxygen Species Production in Contracting Skeletal Muscle. Antioxid Redox Signal 2011; 15:2477–2486. PubMed | CrossRef

Johannsen DL, Conley KE, Bajpeyi S, Punyanitya M, et al. Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity. J Clin Endocrinol Metab 2012; 97:242–250. PubMed | CrossRef

King GW, Stylianou AP, Kluding PM, Jernigan SD, et al. Effects of Age and Localized Muscle Fatigue on Ankle Plantar Flexor Torque Development. J Geriatr Phys Ther 2012; 35:8–14. View Full Text | PubMed | CrossRef

Koster A, Ding JZ, Stenholm S, Caserotti P, et al. Does the Amount of Fat Mass Predict Age-Related Loss of Lean Mass, Muscle Strength, and Muscle Quality in Older Adults? J Gerontol Ser A-Biol Sci Med Sci 2011; 66:888–895.

Larkin LM, Davis CS, Sims-Robinson C, Kostrominova TY, et al. Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation. Am J Physiol-Regul Integr Comp Physiol 2011; 301:R1400–R1407. PubMed | CrossRef

Larsen RG, Callahan DM, Foulis SA, Kent-Braun JA. Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior. Appl Physiol Nutr Metab 2012; 37:88–99.

▪▪. Li Y, Lee Y, Thompson WJ. Changes in aging mouse neuromuscular junctions are explained by degeneration and regeneration of muscle fiber segments at the synapse. J Neurosci 2011; 31:14910–14919. [51]

Liu XH, Yao S, Qiao RF, Levine AC, et al. Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression. Biochem Biophys Res Commun 2011; 414:165–169. PubMed | CrossRef

▪▪. MacDonald SW, Karlsson S, Rieckmann A, et al. Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors. J Neurosci 2012; 32:8186–8191. [19]

▪▪. Manini TM, Clark BC. Dynapenia and aging: an update. J Gerontol 2011. [01]

McKiernan SH, Colman RJ, Aiken E, Evans TD, et al. Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys. Exp Gerontol 2012; 47:229–236. View Full Text | PubMed | CrossRef

Miller CJ, Gounder SS, Kannan S, Goutam K, et al. Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. Biochim Biophys Acta-Mol Basis Dis 2012; 1822:1038–1050. PubMed | CrossRef

Njemini R, Smitz J, Demanet C, Sosso M, et al. Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition. Arch Gerontol Geriatr 2011; 53:359–363. PubMed | CrossRef

Ogawa M, Yasuda T, Abe T. Component characteristics of thigh muscle volume in young and older healthy men. Clin Physiol Funct Imaging 2012; 32:89–93. View Full Text | PubMed | CrossRef

Ogura Y, Naito H, Kakigi R, Ichinoseki-Sekine N, et al. Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle. Acta Physiol 2011; 202:683–690.

▪. Pannese E. Morphological changes in nerve cells during normal aging. Brain Struct Funct 2011; 216:85–89. [15]

Peixoto JG, Dias JMD, Dias RC, da Fonseca ST, et al. Relationships between measures of muscular performance, proprioceptive acuity, and aging in elderly women with knee osteoarthritis. Arch Gerontol Geriatr 2011; 53:E253–E257. PubMed | CrossRef

Pennings B, Groen B, de Lange A, Gijsen AP, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol-Endocrinol Metab 2012; 302:E992–E999. PubMed | CrossRef

Phillips BE, Hill DS, Atherton PJ. Regulation of muscle protein synthesis in humans. Curr Opin Clin Nutr Metab Care 2012; 15:58–63. View Full Text | PubMed | CrossRef

Quadrilatero J, Alway SE, Dupont-Versteegden EE. Skeletal muscle apoptotic response to physical activity: potential mechanisms for protection. Appl Physiol Nutr Metab 2011; 36:608–617.

Raj IS, Bird SR, Shield AJ. Reliability of ultrasonographic measurement of the architecture of the vastus lateralis and gastrocnemius medialis muscles in older adults. Clin Physiol Funct Imaging 2012; 32:65–70. View Full Text | PubMed

Reid KF, Doros G, Clark DJ, Patten C, et al. Muscle power failure in mobility-limited older adults: preserved single fiber function despite lower whole muscle size, quality and rate of neuromuscular activation. Eur J Appl Physiol 2012; 112:2289–2301. PubMed | CrossRef

Ribom EL, Mellstrom D, Ljunggren O, Karlsson MK. Population-based reference values of handgrip strength and functional tests of muscle strength and balance in men aged 70-80 years. Arch Gerontol Geriatr 2011; 53:E114–E117. PubMed | CrossRef

Rivas DA, Morris EP, Fielding RA. Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle. Acta Physiol 2011; 202:691–701.

Rowan SL, Purves-Smith FM, Solbak NM, Hepple RT. Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles. Exp Gerontol 2011; 46:660–669. View Full Text | PubMed

Samuel D, Rowe P, Hood V, Nicol A. The relationships between muscle strength, biomechanical functional moments and health-related quality of life in non-elite older adults. Age Ageing 2012; 41:224–230. View Full Text | PubMed | CrossRef

Sanchis-Gomar F, Gomez-Cabrera MC, Vina J. The loss of muscle mass and sarcopenia: Non hormonal intervention. Exp Gerontol 2011; 46:967–969. View Full Text | PubMed | CrossRef

Seene T, Kaasik P, Riso EM. Review on aging, unloading and reloading: Changes in skeletal muscle quantity and quality. Arch Gerontol Geriatr 2012; 54:374–380. PubMed | CrossRef

Shimada H, Sturnieks D, Endo Y, Kimura Y, et al. Relationship between whole body oxygen consumption and skeletal muscle glucose metabolism during walking in older adults: FDG PET study. Aging Clin Exp Res 2011; 23:175–182. PubMed | CrossRef

▪▪. Smith AE, Ridding MC, Higgins RD, et al. Cutaneous afferent input does not modulate motor intracortical inhibition in ageing men. Eur J Neurosci 2011; 34:1461–1469. [24]

Sung JY, Woo CH, Kang YJ, Lee KY, et al. AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway. Biochem Biophys Res Commun 2011; 413:143–148. PubMed | CrossRef

Tardif N, Salles J, Landrier JF, Mothe-Satney I, et al. Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats. Clin Nutr 2011; 30:799–806. PubMed | CrossRef

Timmerman KL, Dhanani S, Glynn EL, Fry CS, et al. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am J Clin Nutr 2012; 95:1403–1412. PubMed | CrossRef

Vidt ME, Daly M, Miller ME, Davis CC, et al. Characterizing upper limb muscle volume and strength in older adults: A comparison with young adults. J Biomech 2012; 45:334–341. PubMed | CrossRef

Warren DT, Shanahan CM. Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging. Biochem Soc Trans 2011; 39:1780–1785. PubMed | CrossRef

Back to Top | Article Outline
Pathophysiology of the anorexia of aging

Review: (pp. 27–32)

Anderson RM, Weindruch R. The caloric restriction paradigm: Implications for healthy human aging. Am J Hum Biol 2012; 24:101–106. PubMed | CrossRef

Bahat G, Tufan F, Saka B, Akin S, et al. Which body mass index (BMI) is better in the elderly for functional status? Arch Gerontol Geriatr 2011; 54:78–81.

▪. Capuron L, Schoecksnadel S, Feart C, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 2011; 70:175–182. [38]

▪. Donini LM, Dominguez LJ, Barbagallo M, et al. Senile anorexia in different geriatric settings in Italy. J Nutr Health Aging 2011; 15:775–781. [03]

▪. Morley JE. Anorexia of aging: a true geriatric syndrome. J Nutr Health Aging 2012; 16:422–425. [24]

Morley JE. Anorexia of aging: A true geriatric syndrome. J Nutr Health Aging 2012; 16:422–425. PubMed | CrossRef

▪. Moss C, Dhillo WS, Frost G, Hickson M. Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing. J Hum Nutr Diet 2012; 25:3–15. [35]

Moss C, Dhillo WS, Frost G, Hickson M. Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing. J Hum Nutr Diet 2012; 25:3–15. View Full Text | PubMed | CrossRef

▪. Ramic E, Pranjic N, Batic-Mujanovic O, et al. The effect of loneliness on malnutrition in elderly population. Med Arh 2011; 65:92–95. [45]

▪. Rolland Y, Perrin A, Gardette V, et al. Screening older people at risk of malnutrition or malnourished using the Simplified Nutritional Appetite Questionnaire (SNAQ): a comparison with the Mini-Nutritional Assessment (MNA) tool. J Am Med Dir Assoc 2012; 13:31–34. [54]

Rosler A, Lehmann F, Krause T, Wirth R, et al. Nutritional and hydration status in elderly subjects: Clinical rating versus bioimpedance analysis. Arch Gerontol Geriatr 2010; 50:E81–E85. PubMed | CrossRef

Wham CA, Teh ROY, Robinson M, Kerse NM. What is associated with nutrition risk in very old age? J Nutr Health Aging 2011; 15:247–251.

Back to Top | Article Outline
Physiology of the ageing gut

Review: (pp. 33–38)

Asuzu DT, Hayashi Y, Izbeki F, Popko LN, et al. Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging. Neurogastroenterol Motil 2011; 23:E309–E323. View Full Text | PubMed | CrossRef

Backhed F. Programming of Host Metabolism by the Gut Microbiota. Ann Nutr Metab 2011; 58:44–52. View Full Text | PubMed | CrossRef

Becker R, Nieczaj R, Egge K, Moll A, et al. Functional Dysphagia Therapy and PEG Treatment in a Clinical Geriatric Setting. Dysphagia 2011; 26:108–116. PubMed | CrossRef

▪▪. Gomez-Pinilla PJ, Gibbons SJ, Sarr MG, et al. Changes in interstitial cells of cajal with age in the human stomach and colon. Neurogastroenterol Motil 2011; 23:36–44. [08]

Jones RM, Mercante JW, Neish AS. Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications. Curr Med Chem 2012; 19:1519–1529. PubMed | CrossRef

Lacquaniti A, Donato V, Chirico V, Buemi A, et al. Obestatin: An Interesting but Controversial Gut Hormone. Ann Nutr Metab 2011; 59:193–199. View Full Text | PubMed | CrossRef

Sirakov M, Plateroti M. The thyroid hormones and their nuclear receptors in the gut: From developmental biology to cancer. Biochim Biophys Acta-Mol Basis Dis 2011; 1812:938–946. PubMed | CrossRef

Takeshita T, Yasui M, Tomioka M, Nakano Y, et al. Enteral Tube Feeding Alters the Oral Indigenous Microbiota in Elderly Adults. Appl Environ Microbiol 2011; 77:6739–6745. PubMed | CrossRef

▪. Tanaka Y, Kato T, Nishida H, et al. Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test. J Neurol 2011; 258:421–426. [45]

Watson RP, Lilley E, Panesar M, Bhalay G, et al. Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport. Neurogastroenterol Motil 2012; 24:65. View Full Text | PubMed | CrossRef

Wyka J, Biernat J, Mikolajczak J, Piotrowska E. Assessment of dietary intake and nutritional status (MNA) in Polish free-living elderly people from rural environments. Arch Gerontol Geriatr 2011; 54:44–49.

Zaharoni H, Rimon E, Vardi H, Friger M, et al. Probiotics improve bowel movements in hospitalized elderly patients - The proage study. J Nutr Health Aging 2011; 15:215–220. PubMed | CrossRef

Back to Top | Article Outline
Nutrition and skin ulcers

Review: (pp. 39–49)

▪. Baldwin C, Weekes CE. Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults. Cochrane Database Syst Rev 2011; CD002008. [23]

▪▪. Blass SC, Goost H, Tolba RH, et al. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT. Clin Nutr 2012; 31:469–475. [31]

Cox J. Predictors of pressure ulcers in adult critical care patients. Am J Crit Care 2011; 20:364–374. PubMed | CrossRef

Demirovic D, Rattan SIS. Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro. Biogerontology 2011; 12:437–444. PubMed | CrossRef

Gantwerker EA, Hom DB. Skin: Histology and Physiology of Wound Healing. Clin Plast Surg 2012; 39:85. PubMed | CrossRef

Ho CH, Powell HL, Collins JF, Bauman WA, et al. Poor Nutrition Is a Relative Contraindication to Negative Pressure Wound Therapy for Pressure Ulcers: Preliminary Observations in Patients with Spinal Cord Injury. Adv Skin Wound Care 2010; 23:508–516. View Full Text | PubMed | CrossRef

▪. Leigh B, Desneves K, Rafferty J, et al. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J Wound Care 2012; 21:150–156. [25]

▪. Ohura T, Nakajo T, Okada S, et al. Evaluation of effects of nutrition intervention on healing of pressure ulcers and nutritional states (randomized controlled trial). Wound Repair Regen 2011; 19:330–336. [29]

Peralta CA, Katz R, De Boer I, Ix J, et al. Racial and Ethnic Differences in Kidney Function Decline among Persons without Chronic Kidney Disease. J Am Soc Nephrol 2011; 22:1327–1334. PubMed | CrossRef

▪. Pham B, Stern A, Chen W, et al. Preventing pressure ulcers in long-term care: a cost-effectiveness analysis. Arch Intern Med 2011; 171:1839–1847. [26]

Plettig J, Johnen CM, Brautigam K, Zeilinger K, et al. Active Wound Dressing With Artificial Capillaries for Temporary Wound Irrigation and Skin Cell Supply. Artif Organs 2012; 36:446–449. View Full Text | PubMed | CrossRef

Posthauer ME, Dorner B, Collins N. Nutrition: A Critical Component of Wound Healing. Adv Skin Wound Care 2011; 23:560–572. View Full Text | PubMed | CrossRef

▪▪. Teno JM, Gozalo P, Mitchell SL, et al. Feeding tubes and the prevention or healing of pressure ulcers. Arch Intern Med 2012; 172:697–701. [28]

▪. Tsutsumi R, Tsutsumi YM, Horikawa YT, et al. Decline in anthropometric evaluation predicts a poor prognosis in geriatric patients. Asia Pac J Clin Nutr 2012; 21:44–51. [07]

▪. Williams JZ, Barbul A. Nutrition and wound healing. Crit Care Nurs Clin North Am 2012; 24:179–200. [02]

Back to Top | Article Outline
Polypharmacy and malnutrition

Review: (pp. 50–55)

Chakkalakal JV, Kuang SH, Buffelli M, Lichtman JW, et al. Mouse transgenic lines that selectively label type I, type IIa, and types IIX plus B skeletal muscle fibers. Genesis 2012; 50:50–58. PubMed | CrossRef

Chang CB, Chen JH, Wen CJ, Kuo HK, et al. Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria. Br J Clin Pharmacol 2011; 72:482–489. PubMed | CrossRef

Clyne B, Bradley MC, Hughes C, Fahey T, et al. Electronic Prescribing and Other Forms of Technology to Reduce Inappropriate Medication Use and Polypharmacy in Older People: A Review of Current Evidence. Clin Geriatr Med 2012; 28:301. PubMed | CrossRef

Faure C, Raynaud-Simon A, Ferry A, Dauge V, et al. Leucine and citrulline modulate muscle function in malnourished aged rats. Amino Acids 2012; 42:1425–1433. PubMed | CrossRef

▪▪. Franssen FME, Spruit MA, Wouters EFM. Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease. Int J COPD 2011; 6:493–501. [10]

Gnjidic D, Le Couteur DG, Kouladjian L, Hilmer SN. Deprescribing Trials: Methods to Reduce Polypharmacy and the Impact on Prescribing and Clinical Outcomes. Clin Geriatr Med 2012; 28:237. PubMed | CrossRef

Hebert-Schuster M, Cottart CH, Laguillier-Morizot C, Raynaud-Simon A, et al. Catalase rs769214 SNP in elderly malnutrition and during renutrition: Is glucagon to blame? Free Radic Biol Med 2011; 51:1583–1588.

▪▪. Heuberger RA, Caudell K. Polypharmacy and nutritional status in older adults. A cross-sectional study. Drugs Aging 2011; 28:315–323. [04]

Hovstadius B, Petersson G. Factors Leading to Excessive Polypharmacy. Clin Geriatr Med 2012; 28:159. PubMed | CrossRef

Jeejeebhoy KN. Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features. Curr Opin Clin Nutr Metab Care 2012; 15:213–219. View Full Text | PubMed | CrossRef

▪▪. Jyrkkä J, Mursu J, Enlund H, et al. Polypharmacy and nutritional status in elderly people. Curr Opin Clin Nutr Metab Care 2012; 15:1–6. [02]

Jyrkka J, Mursu J, Enlund H, Lonnroos E. Polypharmacy and nutritional status in elderly people. Curr Opin Clin Nutr Metab Care 2012; 15:1–6. View Full Text | PubMed | CrossRef

Lapasset L, Milhavet O, Prieur A, Besnard E, et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev 2011; 25:2248–2253. PubMed | CrossRef

Mizokami F, Koide Y, Noro T, Furuta K. Polypharmacy With Common Diseases in Hospitalized Elderly Patients. Am J Geriatr Pharmacother 2012; 10:123–128. PubMed | CrossRef

Nagai K, Yamada M, Uemura K, Yamada Y, et al. Differences in muscle coactivation during postural control between healthy older and young adults. Arch Gerontol Geriatr 2011; 53:338–343. PubMed | CrossRef

Ni W, Le Guiner C, Gernoux G, Penaud-Budloo M, et al. Longevity of rAAV vector and plasmid DNA in blood after intramuscular injection in nonhuman primates: implications for gene doping. Gene Ther 2011; 18:709–718. View Full Text | PubMed | CrossRef

Nobili A, Marengoni A, Tettamanti M, Salerno F, et al. Association between clusters of diseases and polypharmacy in hospitalized elderly patients: Results from the REPOSI study. Eur J Intern Med 2011; 22:597–602. PubMed | CrossRef

Patterson SM, Hughes C, Kerse N, Cardwell CR, et al. Interventions to improve the appropriate use of polypharmacy for older people - art. no. CD008165. Cochrane Database Syst Rev 2012:8165.

Richardson K, Ananou A, Lafortune L, Brayne C, et al. Variation Over Time in the Association between Polypharmacy and Mortality in the Older Population. Drugs Aging 2011; 28:547–560. View Full Text | PubMed | CrossRef

Ruberu RP, Fitzgerald SP. Clinical Practice Guidelines for Chronic Diseases-Understanding and Managing Their Contribution to Polypharmacy. Clin Geriatr Med 2012; 28:187. PubMed | CrossRef

Saka B, Kaya O, Ozturk GB, Erten N, et al. Malnutrition in the elderly and its relationship with other geriatric syndromes. Clin Nutr 2010; 29:745–748. PubMed | CrossRef

▪. Sergi G, De Rui M, Sarti S, et al. Polypharmacy in the elderly: can comprehensive geriatric assessment reduce inappropriate medication use? Drugs Aging 2011; 28:509–518. [13]

Sergi G, De Rui M, Sarti S, Manzato E. Polypharmacy in the Elderly Can Comprehensive Geriatric Assessment Reduce Inappropriate Medication Use? Drugs Aging 2011; 28:509–518.

Shah BM, Hajjar ER. Polypharmacy, Adverse Drug Reactions, and Geriatric Syndromes. Clin Geriatr Med 2012; 28:173. PubMed | CrossRef

Tamura BK, Bell CL, Inaba M, Masaki KH. Factors Associated With Polypharmacy in Nursing Home Residents. Clin Geriatr Med 2012; 28:199. PubMed | CrossRef

Toffanello ED, Inelmen EM, Minicuci N, Campigotto F, et al. Ten-year trends in vitamin intake in free-living healthy elderly people: The risk of subclinical malnutrition. J Nutr Health Aging 2011; 15:99–103. PubMed | CrossRef

Vischer UM. Reply from Vischer et al. The high prevalence of malnutrition in elderly diabetic patients: implications for anti-diabetic drug treatments. Diabetic Med 2011; 28:123–124. View Full Text | PubMed | CrossRef

Wham CA, Teh ROY, Robinson M, Kerse NM. What is associated with nutrition risk in very old age? J Nutr Health Aging 2011; 15:247–251.

Back to Top | Article Outline
Docosahexaenoic acid (DHA) and cognitive function

Basselin M, Ramadan E, Rapoport SI. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. Brain Res Bull 2012; 87:154–171. PubMed | CrossRef

Benton D, Winichagoon P, Ng TP, Tee ES, et al. Symposium on nutrition and cognition: towards research and application for different life stages. Asia Pac J Clin Nutr 2012; 21:104–124.

Chiu CC, Frangou S, Chang CJ, Chiu WC, et al. Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. Am J Clin Nutr 2012; 95:420–427. PubMed | CrossRef

Dangour AD, Andreeva VA, Sydenham E, Uauy R. Omega 3 fatty acids and cognitive health in older people. Br J Nutr 2012; 107:S152–S158. PubMed | CrossRef

Hamer M, Bates CJ, Mishra GD. Depression, Physical Function, and Risk of Mortality: National Diet and Nutrition Survey in Adults Older Than 65 Years. Am J Geriatr Psychiatr 2011; 19:72–78.

Jackson PA, Reay JL, Scholey AB, Kennedy DO. DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. Br J Nutr 2012; 107:1093–1098. PubMed | CrossRef

Liu SH, Chang CD, Chen PH, Su JR, et al. Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. Brain Res1451: 27.

Luchtman DW, Meng Q, Song C. Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease. Behav. Brain Res 2012; 226:386–396.

Mazereeuw G, Lanctot KL, Chau SA, Swardfager W, et al. Effects of omega-3 fatty acids on cognitive performance: a meta-analysis - art. no. 1482.e17. Neurobiol Aging 2012; 33:E17. PubMed

Pan JP, Zhang HQ, Wei W, Guo YF, et al. Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. Brain Res1412:15.

Samieri C, Feart C, Proust-Lima C, Peuchant E, et al. Omega-3 fatty acids and cognitive decline: modulation by ApoE epsilon 4 allele and depression - art. no. 2317.e13. Neurobiol Aging 2011; 32:E13. PubMed

Sinn N, Milte CM, Street SJ, Buckley JD, et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. Br J Nutr 2012; 107:1682–1693. PubMed | CrossRef

Steiner B, Witte V, Floel A. Lifestyle and cognition. What do we know from the aging and neurodegenerative brain? Nervenarzt 2011; 82:1566.

Stough C, Downey L, Silber B, Lloyd J, et al. The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population - art. no. 824.e1. Neurobiol Aging 2012; 33:E1. PubMed

Ubeda N, Achon M, Varela-Moreiras G. Omega 3 fatty acids in the elderly. Br J Nutr 2012; 107:S137–S151. PubMed | CrossRef

Vakhapova V, Richter Y, Cohen T, Herzog Y, et al. Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension - art. no. 79. BMC Neurol 2011; 11:28.

Back to Top | Article Outline
Longevity: is there a limit?

Baker DJ, Wijshake T, Tchkonia T, Le Brasseur NK, et al. Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders. Nature 2011; 479:232.

Barzilai N, Huffman DM, Muzumdar RH, Bartke A. The Critical Role of Metabolic Pathways in Aging. Diabetes 2012; 61:1315–1322. View Full Text | PubMed | CrossRef

Dunn CD. Running on empty: Does mitochondrial DNA mutation limit replicative lifespan in yeast? Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiae. Bioessays 2011; 33:742–748. View Full Text | PubMed | CrossRef

Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Central Adaptations to Repetitive Grasping in Healthy Aging. Brain Topogr 2011; 24:292–301. PubMed | CrossRef

Feltes BC, Poloni JD, Bonatto D. The developmental aging and origins of health and disease hypotheses explained by different protein networks. Biogerontology 2011; 12:293–308. PubMed | CrossRef

Fort AT. State of the Art in Anti-Aging Trends. Clin Geriatr Med 2011; 27:507. PubMed | CrossRef

Fulle S, Centurione L, Mancinelli R, Sancilio S, et al. Stem Cell Ageing and Apoptosis. Curr Pharm Design 2012; 18:1694–1717.

Giralt A, Villarroya F. SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. Biochem J 2012; 444:1–10. PubMed | CrossRef

Lavasani M, Robinson AR, Lu AP, Song MJ, et al. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model - art. no. 608. Nat Commun 2012:3.

Mao PZ, Gallagher P, Nedungadi S, Manczak M, et al. Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: Implications for aging. Biochim Biophys Acta-Mol Basis Dis 2012; 1822:111–119. PubMed | CrossRef

Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, et al. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency A roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle 2011; 10:3658–3677. PubMed | CrossRef

Monickaraj F, Aravind S, Gokulakrishnan K, Sathishkumar C, et al. Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes. Mol Cell Biochem 2012; 365:343–350. PubMed | CrossRef

Montgomery MK, Hulbert AJ, Buttemer WA. Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production. Exp Gerontol 2012; 47:203–210. View Full Text | PubMed | CrossRef

Ottaviani E, Ventura N, Mandrioli M, Cande la M, et al. Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms. Biogerontology 2011; 12:599–609. PubMed | CrossRef

Vrailas-Mortimer A, del Rivero T, Mukherjee S, Nag S, et al. A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. Dev Cell 2011; 21:783–795.

Yee M, White RJ, Awad HA, Bates WA, et al. Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice. Am J Pathol 2011; 178:2601–2610. PubMed | CrossRef

Back to Top | Article Outline
Nutrition and bone health: influence of age

Beattie KA, MacIntyre NJ, Ramadan K, Inglis D, et al. Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis. Arthritis Care Res 2012; 64:22–29. PubMed | CrossRef

Benetou V, Orfanos P, Zylis D, Sieri S, et al. Diet and hip fractures among elderly Europeans in the EPIC cohort. Eur J Clin Nutr 2011; 65:132–139. View Full Text | PubMed | CrossRef

Bracco P, Oral E. Vitamin E-stabilized UHMWPE for Total Joint Implants: A Review. Clin Orthop Rel Res 2011; 469:2286–2293. PubMed | CrossRef

da Cunha FM, Demasi M, Kowaltowski AJ. Aging and calorie restriction modulate yeast redox state, oxidized protein removal, and the ubiquitin-proteasome system. Free Radic Biol Med 2011; 51:664–670. PubMed | CrossRef

Garber G, Smith LA, Reenan RA, Rogina B. Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging. Fly 2012; 6:57–67.

Hardcastle AC, Aucott L, Fraser WD, Reid DM, et al. Dietary patterns, bone resorption and bone mineral density in early post-menopausal Scottish women. Eur J Clin Nutr 2011; 65:378–385. View Full Text | PubMed | CrossRef

Hippe B, Zwielehner J, Liszt K, Lassl C, et al. Quantification of butyryl CoA:acetate CoA-transferase genes reveals different butyrate production capacity in individuals according to diet and age. FEMS Microbiol Lett 2011; 316:130–135. PubMed | CrossRef

Hosoi T. Genetic aspects of osteoporosis. J Bone Miner Metab 2010; 28:601–607. View Full Text | PubMed | CrossRef

Johannesdottir F, Aspelund T, Siggeirsdottir K, Jonsson BY, et al. Mid-Thigh Cortical Bone Structural Parameters, Muscle Mass and Strength, and Association with Lower Limb Fractures in Older Men and Women (AGES-Reykjavik Study). Calcif Tissue Int 2012; 90:354–364.

Karsenty G, Ferron M. The contribution of bone to whole-organism physiology. Nature 2012; 481:314–320. View Full Text | PubMed | CrossRef

Lin YC, Pan WH. Bone mineral density in adults in Taiwan: results of the Nutrition and Health Survey in Taiwan 2005-2008 (NAHSIT 2005-2008). Asia Pac J Clin Nutr 2011; 20:283–291. PubMed

Loeser RF. Aging and osteoarthritis. Curr Opin Rheumatol 2011; 23:492–496. PubMed | CrossRef

Miljkovic I, Bodnar LM, Cauley JA, Bunker CH, et al. Low prevalence of vitamin d deficiency in elderly afro-caribbean men. Ethn Dis 2011; 21:79–84. PubMed

Montagnani A, Gonnelli S, Alessandri M, Nuti R. Osteoporosis and risk of fracture in patients with diabetes: an update. Aging Clin Exp Res 2011; 23:84–90. PubMed | CrossRef

Moschonis G, Kanellakis S, Papaioannou N, Schaafsma A, et al. Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II. J Bone Miner Metab 2011; 29:501–506. PubMed | CrossRef

Orchard TS, Pan XL, Cheek F, Ing SW, et al. A systematic review of omega-3 fatty acids and osteoporosis. Br J Nutr 2012; 107:S253–S260. PubMed | CrossRef

Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, et al. Vitamin D-Binding Protein Modifies the Vitamin D-Bone Mineral Density Relationship. J Bone Miner Res 2011; 26:1609–1616. PubMed | CrossRef

Rizzoli R. Management of the oldest old with osteoporosis. Eur Geriatr Med 2010; 1:15–21.

Rosen CJ. NUTRITION Vitamin D and falls-are intermittent, high doses better? Nat Rev Endocrinol 2011; 7:695–696.

Sanchez-Riera L, Wilson N, Kamalaraj N, Nolla JM, et al. Osteoporosis and fragility fractures. Best Pract Res Clin Rheumatol 2010; 24:793–810. PubMed | CrossRef

Yamauchi M, Yamaguchi T, Nawata K, Takaoka S, et al. Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women. Clin Nutr 2010; 29:761–765. PubMed | CrossRef

Back to Top | Article Outline
Socio - economic influence on nutrition quality and quantity and body mass index in the elderly

Comans TA, Currin ML, Brauer SG, Haines TP. Factors associated with quality of life and caregiver strain amongst frail older adults referred to a community rehabilitation service: implications for service delivery. Disabil Rehabil 2011; 33:1215–1221. PubMed | CrossRef

Greco SM, Vincent C. Disability & Aging: An Evolutionary Concept Analysis. J Gerontol Nurs 2011; 37:18–27. PubMed | CrossRef

Hirakawa Y, Kuzuya M, Enoki H, Uemura K. Information needs and sources of family caregivers of home elderly patients. Arch Gerontol Geriatr 2011; 52:202–205. PubMed | CrossRef

Huang CJ, Fan YC, Liu JF, Tsai PS. Characteristics and nutrient intake of Taiwanese elderly vegetarians: evidence from a national survey. Br J Nutr 2011; 106:451–460. PubMed | CrossRef

Isaia G, Mondino S, Germinara C, Cappa G, et al. Malnutrition in an elderly demented population living at home. Arch Gerontol Geriatr 2011; 53:249–251. PubMed | CrossRef

Liu BCP, Leung DSY, Chi I. Social functioning, polypharmacy and depression in older Chinese primary care patients. Aging Ment Health 2011; 15:732–741. PubMed | CrossRef

Massoulard A, Bonnabau H, Gindre-Poulvelarie L, Baptistev A, et al. Analysis of the food consumption of 87 elderly nursing home residents, depending on food texture. J Nutr Health Aging 2011; 15:192–195. PubMed | CrossRef

Raynaud-Simon A, Revel-Delhom C, Hebuterne X. Clinical practice guidelines from the French health high authority: Nutritional support strategy in protein-energy malnutrition in the elderly. Clin Nutr 2011; 30:312–319. PubMed | CrossRef

Rondanelli M, Opizzi A, Antoniello N, Boschi F, et al. Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients. Clin Nutr 2011; 30:571–577. PubMed | CrossRef

Sorbye LW. Cancer in home care: Unintended weight loss and ethical challenges. A cross-sectional study of older people at 11 sites in Europe. Arch Gerontol Geriatr 2011; 53:64–69. PubMed | CrossRef

Tyrovolas S, Tountas Y, Polychronopoulos E, Panagiotakos DB. The implications of nutrition services within the health care system on the quality of life and longevity, in developed countries: a re-analysis of 38 studies. Cent Eur J Public Health 2011; 19:13–19. PubMed

Wham C, Carr R, Heller F. Country of origin predicts nutrition risk among community living older people. J Nutr Health Aging 2011; 15:253–258. PubMed | CrossRef

Back to Top | Article Outline
Ageing and optical health

Aquilani R, Zuccarelli GC, Dioguardi FS, Baiardi P, et al. Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients. Arch Gerontol Geriatr 2011; 52:E123–E128. PubMed | CrossRef

Steinman BA, Vasunilashorn S. Biological risk of older adults with visual impairments. J Nutr Health Aging 2011; 15:296–302. PubMed | CrossRef

Back to Top | Article Outline
Neurological conditions and ageing

Amtul Z, Uhrig M, Wang L, Rozmahel RF, et al. Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight - art. no. 831.e21. Neurobiol Aging 2012; 33:E21. PubMed

Bradley MA, Xiong-Fister S, Markesbery WR, Lovell MA. Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression. Neurobiol Aging 2012; 33:1034–1044. PubMed | CrossRef

Breit SN, Johnen H, Cook AD, Tsai VWW, et al. The TGF-beta superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors 2011; 29:187–195. PubMed | CrossRef

de Wilde MC, Kamphuis P, Sijben JWC, Scheltens P. Utility of imaging for nutritional intervention studies in Alzheimer's disease. Eur J Pharmacol 2011; 668:S59–S69. View Full Text | PubMed | CrossRef

Feng L. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline. Am J Clin Nutr 2012; 95:1289–1290. PubMed | CrossRef

Fernandez-Fernandez L, Comes G, Bolea I, Valente T, et al. LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease. Behav. Brain Res 2012; 228:261–271.

Ferry M, Roussel AM. Micronutrient status and cognitive decline in ageing. Eur Geriatr Med 2011; 2:15–21.

Ford AH. Vitamins B-12, B-6, and folic acid for cognition in older men (vo l 75, pg 1540, 2010). Neurology 2011; 77:804. View Full Text | PubMed | CrossRef

Ford AH, Flicker L, Hankey GJ, Norman P, et al. Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study. Mol Psychiatr 2012; 17:559–566.

Frisardi V, Panza F, Farooqui AA. Late-life depression and Alzheimer's disease: The glutamatergic system inside of this mirror relationship. Brain Res Rev 2011; 67:344–355. PubMed | CrossRef

Gu Y, Schupf N, Cosentino SA, Luchsinger JA, et al. Nutrient intake and plasma beta-amyloid. Neurology 2012; 78:1832–1840. View Full Text | PubMed | CrossRef

Henderson ST, Poirier J. Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study - art. no. 137. BMC Med Genet 2011; 12:12.

Hoffmann F, van den Bussche H, Wiese B, Schon G, et al. Impact of geriatric comorbidity and polypharmacy on cholinesterase inhibitors prescribing in dementia - art. no. 190. BMC Psychiatry 2011; 11:6.

Kennedy DO, Haskell CF. Vitamins and. Cognition 2011; 71: What is the Evidence? Drugs, 1957–1971.

Kesse-Guyot E, Amieva H, Castetbon K, Henegar A, et al. Adherence to nutritional recommendations and subsequent cognitive performance: findings from the prospective Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI. MAX 2) study. Am J Clin Nutr 2011; 93:200–210. PubMed | CrossRef

Kim DH, Park SJ, Kim JM, Jeon SJ, et al. Cognitive dysfunctions induced by a cholinergic blockade and A beta(25-35) peptide are attenuated by salvianolic acid B. Neuropharmacology 2011; 61:1432–1440. View Full Text | PubMed | CrossRef

Kumar A, Prakash A, Pahwa D. Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat. Brain Res Bull 2011; 85:158–168. PubMed | CrossRef

Lau DT, Mercaldo ND, Shega JW, Rademaker A, et al. Functional Decline Associated With Polypharmacy and Potentially Inappropriate Medications in Community-Dwelling Older Adults With Dementia. Am J Alzheimers Dis Other Dement 2011; 26:606–615. PubMed | CrossRef

Llewellyn DJ, Lang IA, Langa KM, Melzer D. Vitamin D and Cognitive Impairment in the Elderly U.S. Population. J Gerontol Ser A-Biol Sci Med Sci 2011; 66:59–65.

Lukiw WJ. Amyloid beta (A beta) peptide modulators and other current treatment strategies for Alzheimer's disease (AD). Expert Opin Emerg Drugs 2012; 17:43–60. CrossRef

Mecocci P, Polidori MC. Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease. Biochim Biophys Acta-Mol Basis Dis 2012; 1822:631–638. PubMed

Miltiadous P, Stamatakis A, Koutsoudaki PN, Tiniakos DG, et al. IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy. Exp Neurol 2011; 231:223–235. View Full Text | PubMed | CrossRef

Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, et al. Tannic Acid Is a Natural beta-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice. J Biol Chem 2012; 287:6912–6927.

Norman K, Stobaus N, Gonzalez MC, Schulzke JD, et al. Hand grip strength: Outcome predictor and marker of nutritional status. Clin Nutr 2011; 30:135–142. PubMed | CrossRef

Opie LH. Inhibition of the Cerebral Renin-Angiotensin System to Limit Cognitive Decline in Elderly Hypertensive Persons. Cardiovasc Drugs Ther 2011; 25:277–279. View Full Text | PubMed | CrossRef

Park D, Joo SS, Kim TK, Lee SH, et al. Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Cognitive Function of Kainic Acid-Induced Learning and Memory Deficit Animals. Cell Transplant 2012; 21:365–371. PubMed | CrossRef

Radhu N, Daskalakis ZJ, Guglietti CL, Farzan F, et al. Cognitive behavioral therapy-related increases in cortical inhibition in problematic perfectionists. Brain Stimul 2012; 5:44–54.

Rahn KA, Slusher BS, Kaplin AI. Glutamate in CNS Neurodegeneration and Cognition and its Regulation by GCPII Inhibition. Curr Med Chem 2012; 19:1335–1345. PubMed | CrossRef

Rane P, Shields J, Heffernan M, Guo Y, et al. The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD. Neuropharmacology 2012; 62:2409–2412. View Full Text | PubMed

Rocha NP, Teixeira AL, Coelho FM, Caramelli P, et al. Peripheral blood mono-nuclear cells derived from Alzheimer's disease patients show elevated baseline levels of secreted cytokines but resist stimulation with beta-amyloid peptide. Mol Cell Neurosci 2012; 49:77–84.

Schiepers OJG, van Boxtel MPJ, de Groot RHM, Jolles J, et al. DNA methylation and cognitive functioning in healthy older adults. Br J Nutr 2012; 107:744–748. PubMed | CrossRef

Serviddio G, Romano AD, Cassano T, Bellanti F, et al. Principles and Therapeutic Relevance for Targeting Mitochondria in Aging and Neurodegenerative Diseases. Curr Pharm Design 2011; 17:2036–2055.

Sultana R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim Biophys Acta-Mol Basis Dis 2012; 1822:748–752. PubMed

Takagi M, Yamasaki H, Endo K, Yamada T, et al. Cognitive decline in a patient with anti-glutamic acid decarboxylase autoimmunity; case report - art. no. 156. BMC Neurol 2011; 11:21.

Tan ZS, Harris WS, Beiser AS, Au R, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology 2012; 78:658–664. View Full Text | PubMed | CrossRef

Walker JG, Batterham PJ, Mackinnon AJ, Jorm AF, et al. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms-the Beyond Ageing Project: a randomized controlled trial. Am J Clin Nutr 2012; 95:194–203.

Wijnhoven HAH, Snijder MB, van Bokhorst-de van der Schueren MA, Deeg DJH, et al. Region-Specific Fat Mass and Muscle Mass and Mortality in Community-Dwelling Older Men and Women. Gerontology 2012; 58:32–40. PubMed | CrossRef

Wisnik P, Chmura J, Ziemba AW, Mikulski T, et al. The effect of branched chain amino acids on psychomotor performance during treadmill exercise of changing intensity simulating a soccer game. Appl Physiol Nutr Metab 2011; 36:856–862.

Back to Top | Article Outline
Physical acturity and ageing

Arias P, Espinosa N, Robles-Garcia V, Cao R, et al. Antagonist muscle co-activation during straight walking and its relation to kinematics: Insight from young, elderly and Parkinson's disease.. Brain Res1455: 21.

Hemmeryckx B, Van Hove CE, Fransen P, Emmerechts J, et al. Progression of the Prothrombotic State in Aging Bmal1-Deficient Mice. Arterioscler Thromb Vasc Biol 2011; 31:2552. View Full Text | PubMed | CrossRef

Holviala J, Kraemer WJ, Sillanpaa E, Karppinen H, et al. Effects of strength, endurance and combined training on muscle strength, walking speed and dynamic balance in aging men. Eur J Appl Physiol 2012; 112:1335–1347. PubMed | CrossRef

Ikezoe T, Mori N, Nakamura M, Ichihashi N. Effects of age and inactivity due to prolonged bed rest on atrophy of trunk muscles. Eur J Appl Physiol 2012; 112:43–48. PubMed | CrossRef

Konopka AR, Trappe TA, Jemiolo B, Trappe SW, et al. Myosin Heavy Chain Plasticity in Aging Skeletal Muscle With Aerobic Exercise Training. J Gerontol Ser A-Biol Sci Med Sci 2011; 66:835–841. View Full Text | PubMed | CrossRef

Lawler JM, Hindle A. Living in a Box or Call of the Wild? Revisiting Lifetime Inactivity and Sarcopenia. Antioxid Redox Signal 2011; 15:2529–2541. PubMed | CrossRef

Nagalingam NA, Lynch SV. Role of the microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 2012; 18:968–980. View Full Text | PubMed | CrossRef

Pasini E, Lahaye SL, Flati V, Assanelli D, et al. Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats. Exp Gerontol 2012; 47:23–28. View Full Text | PubMed | CrossRef

Pereira A, Izquierdo M, Silva AJ, Costa AM, et al. Effects of high-speed power training on functional capacity and muscle performance in older women. Exp Gerontol 2012; 47:250–255. View Full Text | PubMed | CrossRef

Radak Z, Bori Z, Koltai E, Fatouros IG, et al. Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle. Free Radic Biol Med 2011; 51:417–423. PubMed | CrossRef

Raso V, Natale VM, Duarte AJD, Greve JMD, et al. Immunological parameters in elderly women: Correlations with aerobic power, muscle strength and mood state. Brain Behav Immun 2012; 26:597–606. PubMed | CrossRef

Tsang WWN, Hui-Chan CWY, Fu SN. Effects of Tai Chi on pre-landing muscle response latency during stepping down while performing a concurrent mental task in older adults. Eur J Appl Physiol 2012; 112:2663–2669. PubMed | CrossRef

Volkers KM, de Kieviet JF, Wittingen HP, Scherder EJA. Lower limb muscle strength (LLMS): Why sedentary life should never start? A review. Arch Gerontol Geriatr 2012; 54:399–414. PubMed | CrossRef

Wisnik P, Chmura J, Ziemba AW, Mikulski T, et al. The effect of branched chain amino acids on psychomotor performance during treadmill exercise of changing intensity simulating a soccer game. Appl Physiol Nutr Metab 2011; 36:856–862.

Xu JZ, Hwang JCY, Lees HA, Wohlgemuth SE, et al. Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy. Exp Gerontol 2012; 47:100–108. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Influence on nutrition on cardiovascular function in the elderly

Boulberdaa M, Urayama K, Nebigil CG. Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions. Cardiovasc Res 2011; 92:191–198. View Full Text | PubMed | CrossRef

Burgaz A, Byberg L, Rautiainen S, Orsini N, et al. Confirmed hypertension and plasma 25(OH)D concentrations amongst elderly men. J Intern Med 2011; 269:211–218. View Full Text | PubMed | CrossRef

Cadore EL, Izquierdo M, Conceicao M, Radaelli R, et al. Echo intensity is associated with skeletal muscle power and cardiovascular performance in elderly men. Exp Gerontol 2012; 47:473–478. View Full Text | PubMed | CrossRef

Cieslik KA, Trial J, Entman ML. Defective Myofibroblast Formation from Mesenchymal Stem Cells in the Aging Murine Heart Rescue by Activation of the AMPK Pathway. Am J Pathol 2011; 179:1792–1806. PubMed | CrossRef

Kaats GR, Preuss HG, Croft HA, Keith SC, et al. A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium. Int J Med Sci 2011; 8:180–191. PubMed | CrossRef

Kim HJ, Ham SA, Kim MY, Hwang JS, et al. PPAR delta Coordinates Angiotensin II-induced Senescence in Vascular Smooth Muscle Cells through PTEN-mediated Inhibition of Superoxide Generation. J Biol Chem 2011; 286:44585–44593. PubMed | CrossRef

Lind PM, Lind L. Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly. Atherosclerosis 2011; 218:207–213. PubMed | CrossRef

Padrao AI, Ferreira R, Vitorino R, Alves RMP, et al. Effect of lifestyle on age-related mitochondrial protein oxidation in mice cardiac muscle. Eur J Appl Physiol 2012; 112: 1467–1474. PubMed | CrossRef

Qian DH, Wu XJ, Jiang H, Gao P, et al. Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells. Int J Mol Med 2011; 28:207–213. PubMed

Rossoni LV, Oliveira RAF, Caffaro RR, Miana M, et al. Cardiac benefits of exercise training in aging spontaneously hypertensive rats. J Hypertens 2011; 29:2349–2358. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Measurement, models, methods and treatments employed in the study of ageing

Bowman GL, Silbert LC, Howieson D, Dodge HH, et al. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology 2012; 78:241–249. View Full Text | PubMed | CrossRef

Chen CS, Kuo YT, Tsai HY, Li CW, et al. Brain Biochemical Correlates of the Plasma Homocysteine Level: A Proton Magnetic Resonance Spectroscopy Study in the Elderly Subjects. Am J Geriatr Psychiatr 2011; 19:618–626.

Chiu CS, Weber H, Adamski S, Rauch A, et al. Non-invasive muscle contraction assay to study rodent models of sarcopenia - art. no. 246. BMC Musculoskelet Disord 2011; 12:28.

da Fonseca LM, da Luz MMP, Lacerda A, Correia M, et al. A simplified rehabilitation program for patients undergoing elective colonic surgery-randomized controlled clinical trial. Int J Colorectal Dis 2011; 26:609–616.

Forrest CM, Mackay GM, Oxford L, Millar K, et al. Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. J Neurochem 2011; 119:136–152. View Full Text | PubMed

Kalyani RR, Metter EJ, Ramachandran R, Chia CW, et al. Glucose and Insulin Measurements From the Oral Glucose Tolerance Test and Relationship to Muscle Mass. J Gerontol Ser A-Biol Sci Med Sci 2012; 67:74–81. View Full Text | PubMed | CrossRef

Lau RWK, Liao LR, Yu FL, Teo T, et al. The effects of whole body vibration therapy on bone mineral density and leg muscle strength in older adults: a systematic review and meta-analysis. Clin Rehabil 2011; 25:975–988. View Full Text | PubMed | CrossRef

Manson JE, Bassuk SS, Lee IM, Cook NR, et al. The VITamin D and OmegA-3 TriaL (VITAL): Rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012; 33:159–171.

Neutel J, Kereiakes DJ, Stoakes KA, Maa JF, et al. Blood Pressure-Lowering Efficacy of an Olmesartan Medoxomil/Hydrochlorothiazide-Based Treatment Algorithm in Elderly Patients (Age >= 65 Years) Stratified by Age, Sex and Race Subgroup Analysis of a 12-Week, Open-Label, Single-Arm, Dose-Titration Study. Drugs Aging 2011; 28:477–490. View Full Text | PubMed | CrossRef

Ozilgen S. Statistical quality control charts: New tools for studying the body mass index of populations from the young to the elderly. J Nutr Health Aging 2011; 15:333–339. PubMed | CrossRef

Pahor M, Cesari M. Designing phase ii b trials in sarcopenia: the best target population. J Nutr Health Aging 2011; 15:725–730. PubMed | CrossRef

Ramel A, Geirsdottir OG, Arnarson A, Thorsdottir I. Regional and total body bioelectrical impedance analysis compared with DXA in Icelandic elderly. Eur J Clin Nutr 2011; 65:978–983. View Full Text | PubMed | CrossRef

Sakuma K, Yamaguchi A. Sarcopenia and Age-Related Endocrine Function - art. no. 127362. Int J Endocrinol 2012:27362.

Schurr K, Sherrington C, Wallbank G, Pamphlett P, et al. The minimum sit-to-stand height test: reliability, responsiveness and relationship to leg muscle strength. Clin Rehabil 2012; 26:656–663. View Full Text | PubMed | CrossRef

Sharples AP, Al-Shanti N, Lewis MP, Stewart CE. Reduction of Myoblast Differentiation Following Multiple Population Doublings in Mouse C2C12 Cells: A Model to Investigate Ageing? J Cell Biochem 2011; 112:3773–3785.

van Himbergen TM, Beiser AS, Ai M, Seshadri S, et al. Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease Results From the Framingham Heart Study. Arch Neurol 2012; 69:594–600. View Full Text | PubMed | CrossRef

Wham CA, Dyall L, Teh ROY, Kerse NM. Nutrition risk: cultural aspects of assessment. Asia Pac J Clin Nutr 2011; 20:632–638. PubMed

Wu SJ, Pan WH, Yeh NH, Chang HY. Trends in nutrient and dietary intake among adults and the elderly: from NAHSIT 1993-1996 to 2005-2008. Asia Pac J Clin Nutr 2011; 20:251–265. PubMed

Yang EF, Lim S, Lim JY, Kim KW, et al. Association between muscle strength and metabolic syndrome in older Korean men and women: the Korean Longitudinal Study on Health and Aging. Metab-Clin Exp 2012; 61:317–324. PubMed | CrossRef

Back to Top | Article Outline
Ageing and cancer

Bauer JM. Nutrition in older persons. Basis for functionality and quality of life. Internist 2011; 52:946–954. PubMed | CrossRef

Candow DG. Sarcopenia: current theories and the potential beneficial effect of creatine application strategies. Biogerontology 2011; 12:273–281. PubMed | CrossRef

Faux NG, Ellis KA, Porter L, Fowler CJ, et al. Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. J Alzheimers Dis 2011; 27:909–922. PubMed

Ford AH, Almeida OP. Effect of Homocysteine Lowering Treatment on Cognitive Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Alzheimers Dis 2012; 29:133–149. PubMed

Kristjansson SR, Jordhoy MS, Nesbakken A, Skovlund E, et al. Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery? J Geriatr Oncol 2010; 1:57–65.

Sorbye LW. Cancer in home care: Unintended weight loss and ethical challenges. A cross-sectional study of older people at 11 sites in Europe. Arch Gerontol Geriatr 2011; 53:64–69. PubMed | CrossRef

Tang SW, Morgan DAL, Winterbottom L, Kennedy H, et al. Optimising the care of primary breast cancer in older women-potential for a dedicated service. J Geriatr Oncol 2010; 1:103–108.

Back to Top | Article Outline
Age related changes in lung function

Battaglia S, Spatafora M, Paglino G, Pedone C, et al. Ageing and COPD affect different domains of nutritional status: the ECCE study. Eur Resp J 2011; 37:1340–1345. PubMed | CrossRef

Fragoso CAV, Gill TM, McAvay G, Yaggi HK, et al. Respiratory Impairment and Mortality in Older Persons: A Novel Spirometric Approach. J Invest Med 2011; 59:1089–1095. View Full Text | PubMed

Georgiopoulou VV, Kalogeropoulos AP, Psaty BM, Rodondi N, et al. Lung Function and Risk for Heart Failure Among Older Adults: The Health ABC Study. Am J Med 2011; 124:334–341. PubMed | CrossRef

Li ZL, Li JF, Bu XN, Liu X, et al. Age-induced augmentation of p38 MAPK phosphorylation in mouse lung. Exp Gerontol 2011; 46:694–702. View Full Text | PubMed

Wilkie SS, Guenette JA, Dominelli PB, Sheel AW. Effects of an aging pulmonary system on expiratory flow limitation and dyspnoea during exercise in healthy women. Eur J Appl Physiol 2012; 112:2195–2204. PubMed | CrossRef

Back to Top | Article Outline
Renal function in the elderly

Boulberdaa M, Urayama K, Nebigil CG. Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions. Cardiovasc Res 2011; 92:191–198. View Full Text | PubMed | CrossRef

Brown EA, Johansson L. Epidemiology and management of end-stage renal disease in the elderly. Nat Rev Nephrol 2011; 7:591–598. View Full Text | PubMed | CrossRef

Chang WC. Dietary intake and the risk of hyperuricemia, gout and chronic kidney disease in elderly Taiwanese men. Aging Male 2011; 14:195–202. PubMed | CrossRef

Choudhury D, Levi M. Kidney aging-inevitable or preventable? Nat Rev Nephrol 2011; 7:706–717.

Faux NG, Ellis KA, Porter L, Fowler CJ, et al. Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. J Alzheimers Dis 2011; 27:909–922. PubMed

Ford AH, Almeida OP. Effect of Homocysteine Lowering Treatment on Cognitive Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Alzheimers Dis 2012; 29:133–149. PubMed

Shavit L, Lifschitz M, Galperin I. Influence of enteric nutrition on blood urea nitrogen (BUN) in very old patients with chronic kidney disease (CKD). Arch Gerontol Geriatr 2011; 54:228–231.

Back to Top | Article Outline
Miscellaneous

Akin FW, Murnane OD, Tampas JW, Clinard CG. The Effect of Age on the Vestibular Evoked Myogenic Potential and Sternocleidomastoid Muscle Tonic Electromyogram Level. Ear Hear 2011; 32:617–622. View Full Text | PubMed | CrossRef

Aquilani R, Zuccarelli GC, Dioguardi FS, Baiardi P, et al. Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients. Arch Gerontol Geriatr 2011; 52:E123–E128. PubMed | CrossRef

Banks LN, Byrne N, Henari S, Morris S, et al. Nutritional status of elderly trauma patients presenting to a South Dublin Teaching Hospital. Eur Geriatr Med 2010; 1:325–329.

Cane S, Ponnappan S, Ponnappan U. Impairment of non-muscle myosin IIA in human CD4(+) T cells contributes to functional deficits in the elderly. Cell Mol Immunol 2012; 9:86–96. PubMed

Coker RH, Wolfe RR. Bedrest and sarcopenia. Curr Opin Clin Nutr Metab Care 2012; 15:7–11. View Full Text | PubMed | CrossRef

Fujimura T, Hotta M, Kitahara T, Takema Y. Loss of contraction force in dermal fibroblasts with aging due to decreases in myosin light chain phosphorylation enzymes. Arch Pharm Res 2011; 34:1015–1022. PubMed | CrossRef

Goronzy JJ, Weyand CM. Immune aging and autoimmunity. Cell Mol Life Sci 2012; 69:1615–1623. PubMed | CrossRef

Huang YC, Lee MS, Pan WH, Wahlqvist ML. Validation of a simplified food frequency questionnaire as used in the Nutrition and Health Survey in Taiwan (NAHSIT) for the elderly. Asia Pac J Clin Nutr 2011; 20:134–140. PubMed

Jackson AS, Janssen I, Sui XM, Church TS, et al. Longitudinal changes in body composition associated with healthy ageing: men, aged 20-96 years. Br J Nutr 2012; 107:1085–1091. PubMed | CrossRef

Katzman W, Cawthon P, Hicks GE, Vittinghoff E, et al. Association of Spinal Muscle Composition and Prevalence of Hyperkyphosis in Healthy Community-Dwelling Older Men and Women. J Gerontol Ser A-Biol Sci Med Sci 2012; 67:191–195.

Leischker AH, Kolb GF, Felschen-Ludwig S. Nutritional status, chewing function and vitamin deficiency in geriatric inpatients. Eur Geriatr Med 2010; 1:207–212.

Liu YH, Jing HJ, Wang J, Zhang RX, et al. Micronutrients decrease incidence of common infections in type 2 diabetes outpatients. Asia Pac J Clin Nutr 2011; 20:375–382. PubMed

Manini TM, Clark BC. Dynapenia and Aging: An Update. J Gerontol Ser A-Biol Sci Med Sci 2012; 67:28–40. View Full Text | PubMed | CrossRef

McGregor KM, Carpenter H, Kleim E, Sudhyadhom A, et al. Motor map reliability and aging: a TMS/fMRI study. Exp. Brain Res 2012; 219:97–106.

Nip WFR, Perry L, McLaren S, Mackenzie A. Dietary intake, nutritional status and rehabilitation outcomes of stroke patients in hospital. J Hum Nutr Diet 2011; 24:460–469.

Przybyszewska J, Zekanowska E, Kedziora-Kornatowska K, Boinska J, et al. Prohepcidin and iron metabolism parameters in the obese elderly patients with anemia. J Nutr Health Aging 2011; 15:259–264. PubMed | CrossRef

Schmitt K, Grimm A, Kazmierczak A, Strosznajder JB, et al. Insights into Mitochondrial Dysfunction: Aging, Amyloid-beta, and Tau-A Deleterious Trio. Antioxid Redox Signal 2012; 16:1456–1466. PubMed | CrossRef

Shen HC, Chen HF, Peng LN, Lin MH, et al. Impact of nutritional status on long-term functional outcomes of post-acute stroke patients in Taiwan. Arch Gerontol Geriatr 2011; 53:E149–E152.

Waters DL, Baumgartner RN. Sarcopenia and Obesity. Clin Geriatr Med 2011; 27:401. PubMed | CrossRef

Back to Top | Article Outline
Protein, amino acid metabolism and therapy
The role of amino acid transporters in nutrition

Review: (pp. 57–65)

▪. Bröer A, Juelich T, Vanslambrouck JM, et al. Impaired nutrient signaling and body weight control in a Na+-neutral amino acid cotransporter (Slc6a19)-deficient mouse. J Biol Chem 2011; 286:26638–26651. [55]

▪▪. Bröer S, Palacin M. The role of amino acid transporters in inherited and acquired diseases. Biochem J 2011; 436:193–211. [05]

▪. Edwards N, Anderson CMH, Gatfield KM, et al. Amino acid derivatives are substrates or nontransported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 2011; 1808:260–270. [07]

▪. Fairweather SJ, Bröer A, O'Mara ML, Bröer S. Intestinal peptidases form functional complexes with the neutral amino acid transporter B0AT1. Biochem J 2012; 446: 135–148. [26]

▪. Fanjul C, Barrenetxe J, Inigo C, et al. Leptin regulates sugar and amino acids transport in the human intestinal cell line Caco-2. Acta Physiol (Oxf) 2012; 205:82–91. [23]

▪▪. Gietzen DW, Aja SM. The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal. Mol Neurobiol 2012; 46:332–348. [46]

▪. Han JM, Jeong SJ, Park MC, et al. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012; 149:410–424. [38]

Le Floc'h N, Otten W, Merlot E. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 2011; 41:1195–1205.

Li FN, Yin YL, Tan B, Kong XF, et al. Leucine nutrition in animals and humans: mTOR signaling and beyond. Amino Acids 2011; 41:1185–1193. PubMed | CrossRef

▪▪. Macotela Y, Emanuelli B, Bang AM, et al. Dietary leucine: an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS ONE 2011; 6:e21187. [53]

▪. Ogier de Baulny H, Schiff M, Dionisi-Vici C. Lysinuric protein intolerance (LPI): a multi organ disease by far more complex than a classic urea cycle disorder. Mol Genet Metab 2012; 106:12–17. [12]

▪. Pinilla J, Aledo JC, Cwiklinski E, et al. SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation? Front Biosci (Elite Ed) 2011; 3:1289–1299. [45]

▪▪. Zoncu R, Bar-Peled L, Efeyan A, et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase. Science 2011; 334:678–683. [39]

Back to Top | Article Outline
Skeletal muscle protein metabolism in human heart failure

Review: (pp. 66–71)

Abulhul E, McDonald K, Martos R, Phelan D, et al. Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide. Clin Ther 2012; 34:91–100. PubMed | CrossRef

▪. Aquilani R, La Rovere MT, Febo O, et al. Preserved muscle protein metabolism in obese patients with chronic heart failure. Int J Cardiol 2012; 160:102–108. [08]

Badalzadeh R, Mohammadi M, Najafi M, Ahmadiasl N, et al. The Additive Effects of Ischemic Postconditioning and Cyclosporine-A on Nitric Oxide Activity and Functions of Diabetic Myocardium Injured by Ischemia/Reperfusion. J Cardiovasc Pharmacol Ther 2012; 17:181–189. View Full Text | PubMed | CrossRef

Barasch E, Gottdiener JS, Aurigemma G, Kitzman DW, et al. The Relationship Between Serum Markers of Collagen Turnover and Cardiovascular Outcome in the Elderly The Cardiovascular Health Study. Circ-Heart Fail 2011; 4:733–739. View Full Text | PubMed | CrossRef

Chatzikyriakou SV, Tziakas DN, Chalikias GK, Stakos D, et al. Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure. Qual Life Res 2012; 21:143–153. PubMed | CrossRef

Collier P, Watson CJ, Voon V, Phelan D, et al. Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure? Eur J Heart Fail 2011; 13:1087–1095.

Crabtree MJ, Channon KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide-Biol Chem 2011; 25:81–88.

Darley-Usmar VM, Ball LE, Chatham JC. Protein O-linked beta-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol 2012; 52:538–549. PubMed | CrossRef

Di Meglio F, Nurzynska D, Castaldo C, Miraglia R, et al. Cardiac shock wave therapy: assessment of safety and new insights into mechanisms of tissue regeneration. J Cell Mol Med 2012; 16:936–942. View Full Text | PubMed | CrossRef

Edgley AJ, Krum H, Kelly DJ. Targeting Fibrosis for the Treatment of Heart Failure: A Role for Transforming Growth Factor-beta. Cardiovasc Ther 2012; 30:e30–e40. View Full Text | PubMed | CrossRef

Efendiev R, Dessauer CW. A Kinase-Anchoring Proteins and Adenylyl Cyclase in Cardiovascular Physiology and Pathology. J Cardiovasc Pharmacol 2011; 58:339–344. View Full Text | PubMed | CrossRef

Farese RV, Sajan MP. Atypical protein kinase C in cardiometabolic abnormalities. Curr Opin Lipidology 2012; 23:175–181. View Full Text | PubMed | CrossRef

Fraccarollo D, Bauersachs J. Cardiomyocyte Mineralocorticoid Receptor Function Post Myocardial Infarction. Trends Cardiovasc Med 2011; 21:42–47. PubMed | CrossRef

Francia P, Balla C, Ricotta A, Uccellini A, et al. Plasma osteopontin reveals left ventricular reverse remodelling following cardiac resynchronization therapy in heart failure. Int J Cardiol 2011; 153:306–310. PubMed | CrossRef

▪. Gielen S, Sandri M, Kozarez I, et al. Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation 2012; 125:2716–2727. [22]

▪▪. Grueter CE, van Rooij E, Johnson BA, et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 2012; 149:671–683. [48]

▪. Gruson D, Ahn SA, Ketelslegers JM, Rousseau MF. Increased plasma myostatin in heart failure. Eur J Heart Fail 2011; 13:734–736. [39]

▪▪. Heineke J, Auger-Messier M, Xu J, et al. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation 2010; 121:419–425. [37]

Kandalam V, Basu R, Moore L, Fan D, et al. Lack of Tissue Inhibitor of Metalloproteinases 2 Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular Matrix Remodeling in Response to Biomechanical Stress. Circulation 2011; 124:2094. View Full Text | PubMed | CrossRef

Kato TS, Chokshi A, Singh P, Khawaja T, et al. Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure. J Heart Lung Transplant 2012; 31:37–45. PubMed | CrossRef

Knoll R, Linke WA, Zou PJ, Miocic S, et al. Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart. CircRes 2011; 109:758. View Full Text | PubMed | CrossRef

Krum H, Elsik M, Schneider HG, Ptaszynska A, et al. Relation of Peripheral Collagen Markers to Death and Hospitalization in Patients With Heart Failure and Preserved Ejection Fraction Results of the I-PRESERVE Collagen Substudy. Circ-Heart Fail 2011; 4:561–568. View Full Text | PubMed | CrossRef

Lakomkin SV, Skvortsov AA, Goryunova TV, Masenko VP, et al. Galectin-3-a New Biomarker for Diagnostics and Outcome of Chronic Heart Failure. Kardiologiya 2012; 52:45–52. PubMed

Lassegue B, San Martin A, Griendling KK. Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System. CircRes 2012; 110:1364–1390. View Full Text | PubMed | CrossRef

▪. Lenk K, Erbs S, Hollriegel R, et al. Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure. Eur J Prev Cardiol 2012; 19:404–411. [41]

Leri A, Kajstura J, Anversa P. Role of Cardiac Stem Cells in Cardiac Pathophysiology: A Paradigm Shift in Human Myocardial Biology. CircRes 2011; 109:941–961. View Full Text | PubMed | CrossRef

Lopez-Andres N, Rossignol P, Iraqi W, Fay R, et al. Association of galectin-3 and fibrosis markers with long-term cardiovascular outcomes in patients with heart failure, left ventricular dysfunction, and dyssynchrony: insights from the CARE-HF (Cardiac Resynchronization in Heart Failure) trial. Eur J Heart Fail 2012; 14:74–81. PubMed | CrossRef

Manhenke C, Orn S, Squire I, Radauceanu A, et al. The prognostic value of circulating markers of collagen turnover after acute myocardial infarction. Int J Cardiol 2011; 150:277–282.

Moore L, Fan D, Basu R, Kandalam V, et al. Tissue inhibitor of metalloproteinases (TIMPs) in heart failure. Heart Fail Rev 2012; 17:693–706. PubMed | CrossRef

Newby LK, Rodriguez I, Finkle J, Becker RC, et al. Troponin measurements during drug development-considerations for monitoring and management of potential cardiotoxicity: An educational collaboration among the Cardiac Safety Research Consortium, the Duke Clinical Research Institute, and the US Food and Drug Administration. Am Heart J 2011; 162:64–73. View Full Text | PubMed | CrossRef

Okumura Y, Watanabe I, Nakai T, Ohkubo K, et al. Impact of Biomarkers of Inflammation and Extracellular Matrix Turnover on the Outcome of Atrial Fibrillation Ablation: Importance of Matrix Metalloproteinase-2 as a Predictor of Atrial Fibrillation Recurrence. J Cardiovasc Electrophysiol 2011; 22:987–993. View Full Text | PubMed | CrossRef

Shah A, Passacquale G, Gkaliagkousi E, Ritter J, et al. Platelet nitric oxide signalling in heart failure: role of oxidative stress. Cardiovasc Res 2011; 91:625–631. View Full Text | PubMed | CrossRef

Shimazu T, Otani H, Yoshioka K, Fujita M, et al. Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. Am J Physiol-Heart Circul Physiol 2011; 301:H2061–H2072.

Takehara N, Matsubara H. Cardiac regeneration therapy: connections to cardiac physiology. Am J Physiol-Heart Circul Physiol 2011; 301:H2169–H2180.

ten Brinke EA, Witkowski TG, Delgado V, Klein P, et al. Myocardial collagen turnover after surgical ventricular restoration in heart failure patients. Eur J Heart Fail 2011; 13:1202–1210. View Full Text | PubMed | CrossRef

▪. Toth MJ, Ward K, vand der Velden J, et al. Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function. J Appl Physiol 2011; 119:892–900. [18]

Turner NA, Porter KE. Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts. IUBMB Life 2012; 64:143–150. PubMed | CrossRef

Tziakas DN, Chalikias GK, Stakos D, Chatzikyriakou SV, et al. Independent and additive prognostic ability of serum carboxy-terminal telopeptide of collagen type-I in heart failure patients: a multi-marker approach with high-negative predictive value to rule out long-term adverse events. Eur J Prev Cardiol 2012; 19:62–71.

van Kimmenade RRJ, Januzzi JL. Emerging Biomarkers in Heart Failure. Clin Chem 2012; 58:127–138. PubMed | CrossRef

Wang XF, Zhang JY, Li L, Zhao XY. Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase. Chin Med J 2011; 124:1876–1884. View Full Text | PubMed

▪. Yoshida T, Semprun-Prieto L, Wainford RD, et al. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology 2012; 153:1411–1420. [35]

Zile MR, De Santis SM, Baicu CF, Stroud RE, et al. Plasma Biomarkers That Reflect Determinants of Matrix Composition Identify the Presence of Left Ventricular Hypertrophy and Diastolic Heart Failure. Circ-Heart Fail 2011; 4:246–254. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
D-Serine: physiology and pathology

Review: (pp. 72–75)

▪▪. Benneyworth MA, Li Y, Basu AC, et al. Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cell Mol Neurobiol 2012; 32:613–624. [06]

Daniels BA, Wood L, Tremblay F, Baldridge WH. Functional evidence for D-serine inhibition of non-N-methyl-D-aspartate ionotropic glutamate receptors in retinal neurons. Eur J Neurosci 2012; 35:56–65. View Full Text | PubMed | CrossRef

▪. Fossat P, Turpin FR, Sacchi S, et al. Glial d-serine gates NMDA receptors at excitatory synapses in prefrontal cortex. Cereb Cortex 2011; 22:595–606. [04]

Fuchs SA, Berger R, de Koning TJ. D-Serine: The right or wrong isoform? Brain Res1401: 15.

▪. Harai T, Inoue R, Fujita Y, et al. Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice. Epilepsy Res 2012. [15]

Lu JM, Gong NA, Wang YC, Wang YX. D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. Br J Pharmacol 2012; 165:1941–1955. View Full Text | PubMed | CrossRef

▪▪. Ma TM, Abazyan S, Abazyan B, et al. Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via d-serine depletion. Mol Psychiatry 2012. [16]

▪▪. Papouin T, Ladepeche L, Ruel Jrm, et al. Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 2012; 150:633–646. [03]

▪. Sasabe J, Miyoshi Y, Suzuki M, et al. d-amino acid oxidase controls motoneuron degeneration through d-serine. Proc Natl Acad Sci US A 2012; 109:627–632. [07]

▪. Turpin FR, Potier B, Dulong JR, et al. Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function. Neurobiol Aging 2012; 32:1495–1504. [05]

Back to Top | Article Outline
L-arginine, tetrahydrobiopterin, nitric oxide and diabetes

Review: (pp. 76–82)

Advani A, Huang QL, Thai K, Advani SL, et al. Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism. Am J Pathol 2011; 178:2205–2214. PubMed | CrossRef

▪. Antoniades C, Bakogiannis C, Leeson P, et al. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. Circulation 2011; 124:335–345. [33]

▪. Beleznai T, Feher A, Spielvogel D, et al. Arginase I contributes to diminished coronary arteriolar dilation in patients with diabetes. Am J Physiol Heart Circ Physiol 2011; 300:H777–H783. [10]

Caplin B, Leiper J. Endogenous Nitric Oxide Synthase Inhibitors in the Biology of Disease Markers, Mediators, and Regulators? Arterioscler Thromb Vasc Biol 2012; 32:1343.

Choi JW, Nahm CH, Lee MH. Relationships of Fetal-Type Erythropoiesis versus Nitric Oxide Production and Glycated Hemoglobin Levels in Diabetics. Ann Clin Lab Sci 2011; 41:224–228. PubMed

▪▪. Cunnington C, Van Assche T, Shirodarla C, et al. Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation 2012; 125:1356–1366. [31]

▪▪. Erez A, Nagamani SCS, Shchelochkov OA, et al. Requirement of argininosuccinate for systemic nitric oxide production. Nature Med 2011; 17:1619–1626. [18]

Ferrini MG, Moon J, Rivera S, Rajfer J, et al. Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-beta 1 therapies in inducible nitric oxide synthase-deficient mice. BJU Int 2012; 109:586–593.

Forstermann U, Li HG. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. Br J Pharmacol 2011; 164:213–223. View Full Text | PubMed | CrossRef

Ghasemi A, Zahediasl S, Azimzadeh I, Azizi F. Increased serum nitric oxide metabolites in dysglycaemia. Ann Hum Biol 2011; 38:577–582. PubMed | CrossRef

▪▪. Haines RJ, Corbin KD, Pendleton LC, Eichler DC. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 2012; 187:26168–26176. [17]

▪. Haines RJ, Corbin KD, Pendleton LC, et al. Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochem Biophy Res Commun 2012; 421:9–14. [15]

Jo H, Otani H, Jo F, Shimazu T, et al. Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. Clin Exp Pharmacol Physiol 2011; 38:485–493. View Full Text | PubMed | CrossRef

Kerr PM, Tam R, Narang D, Potts K, et al. Endothelial calcium-activated potassium channels as therapeutic targets to enhance availability of nitric oxide. Can J Physiol Pharmacol 2012; 90:739–752. PubMed | CrossRef

▪▪. Monti LD, Setola E, Lucotti PCG, et al. Effect of a long-term oral L-arginine supplementation on glucose metabolism: a randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab 2012; 14:893–900. doi: 10.1111/j.1463-1326.2012.01615.x. [22]

▪. Mun GI, Kim I-S, Lee B-H, Boo YC. Endothelial argininosuccinate synthase 1 regulates nitric oxide production and monocyte adhesion under static and laminar shear stress conditions. J Biol Chem 2011; 286:2536–2542. [16]

Natali A, Ferrannini E. Endothelial dysfunction in type 2 diabetes. Diabetologia 2012; 55:1559–1563. View Full Text | PubMed | CrossRef

Oh YS, Lee YJ, Park EY, Jun HS. Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production. Diabetes-Metab Res Rev 2011; 27:813–819. PubMed | CrossRef

▪. Ohashi A, Mamada K, Tsuboi I, et al. Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the luminal surface of rat endothelial cells. Mol Genet Metab 2011; 104:404–406. [37]

▪. Tripolt NJ, Meinitzer A, Eder M, et al. Multifactorial risk factor intervention in patients with type 2 diabetes improves arginine bioavailability ratios. Diabet Med 2012; 29:e365–e368. doi:10.1111/j.1464-5491.2012.03743.x [07]

Yamagishi S, Matsui T. Nitric oxide, a janus-faced therapeutic target for diabetic microangiopathy-Friend or foe? Pharmacol Res 2011; 64:187–194.

▪. Youn JY, Gao L, Cai H. The p47phox- and NADPH oxidase organizer 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes. Diabetologia 2012; 55:2069–2079. [34]

Youn JY, Gao L, Cai H. The p47(phox)- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes. Diabetologia 2012; 55:2069–2079. View Full Text | PubMed | CrossRef

Back to Top | Article Outline
Muscle protein anabolism in type 2 diabetes

Review: (pp. 83–88)

Adegoke OAJ, Abdullahi A, Tavajohi-Fini P. mTORC1 and the regulation of skeletal muscle anabolism and mass. Appl Physiol Nutr Metab 2012; 37:395–406.

▪▪. Bassil M, Burgos S, Marliss EB, et al. Hyperaminoacidaemia at postprandial levels does not modulate glucose metabolism in type 2 diabetes mellitus. Diabetologia 2011; 54:1810–1818. [23]

▪. Bassil M, Marliss EB, Morais JA, et al. Postprandial hyperaminoacidaemia overcomes insulin resistance of protein anabolism in men with type 2 diabetes. Diabetologia 2011; 54:648–656. [01]

▪. Brandt C, Nielsen AR, Fischer CP, et al. Plasma and muscle myostatin in relation to type 2 diabetes. PLoS One 2012; 7:e37236. [09]

▪. Geirsdottir OG, Arnarson A, Briem K, et al. Effect of 12-Week Resistance Exercise Program on Body Composition, Muscle Strength, Physical Function, and Glucose Metabolism in Healthy, Insulin-Resistant, and Diabetic Elderly Icelanders. J Gerontol A Biol Sci Med Sci 2012. [44]

▪▪. Leenders M, Verdijk LB, van der Hoeven L, et al. Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men. J Nutr 2011; 141:1070–1107. [32]

Loh K, Merry TL, Galic S, Wu BJ, et al. T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice. Diabetologia 2012; 55:468–478. View Full Text | PubMed | CrossRef

Loinard C, Zouggari Y, Rueda P, Ramkhelawon B, et al. C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression. Circulation 2012; 125:1014. View Full Text | PubMed | CrossRef

▪. Nuttall F, Gannon M. Effect of a LoBAG30 diet on protein metabolism in men with type 2 diabetes. Nutr Metab (Lond) 2012; 9:43. [31]

▪. Otterman NM, van Schie CHM, van der Schaaf M, et al. An exercise programme for patients with diabetic complications: a study on feasibility and preliminary effectiveness. Diabet Med 2011; 28:212–217. [43]

▪. Pennings B, Boirie Y, Senden JM, et al. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 2011; 93:997–1005. [30]

▪▪. Srikanthan P, Karlamangla AS. Relative muscle mass is inversely associated with insulin resistance and prediabetes. findings from The Third National Health And Nutrition Examination Survey. J Clin Endocrinol Metab 2011; 96:2898–2903. [08]

▪. Wall BT, Dirks ML, Verdijk LB, et al. Neuromuscular electrical stimulation increases muscle protein synthesis in elderly, type 2 diabetic men. Am J Physiol Endocrinol Metab 2012. [40]

Back to Top | Article Outline
Methionine metabolic pathway in alcoholic liver injury

Review: (pp. 89–95)

Cohen JI, Chen XC, Nagy LE. Redox Signaling and the Innate Immune System in Alcoholic Liver Disease. Antioxid Redox Signal 2011; 15:523–534. PubMed | CrossRef

Gao B, Bataller R. Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets. Gastroenterology 2011; 141:1572–1585. PubMed | CrossRef

Garcia-Ruiz C, Mari M, Colell A, Morales A, et al. Metabolic Therapy: Lessons from Liver Diseases. Curr Pharm Design 2011; 17:3933–3944.

▪▪. Kharbanda KK, Todero SL, King AL, et al. Betaine treatment attenuates chronic ethanol-induced hepatic steatosis and alterations to the mitochondrial respiratory chain proteome. Int J Hepatol 2012; 2012:962183. [22]

Koretz RL, Avenell A, Lipman TO. Nutritional support for liver disease - art. no. CD008344. Cochrane Database Syst Rev 2012:8344.

Martin-Venegas R, Brufau MT, Mercier Y, Geraert PA, et al. Intestinal cell conversion of DL-2-hydroxy-(4-methylthio)butanoic acid in vitro: dietary up-regulation by this methionine precursor. Br J Nutr 2011; 106:350–356. PubMed | CrossRef

▪▪. Medici V, Virata MC, Peerson JM, et al. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcohol Clin Exp Res 2011; 35:1960–1965. [40]

Medici V, Virata MC, Peerson JM, Stabler SP, et al. S-adenosyl-L-methionine Treatment for Alcoholic Liver Disease: A Double-Blinded, Randomized, Placebo-Controlled Trial. Alcoholism (NY) 2011; 35:1960–1965.

▪▪. Teng YW, Mehedint MG, Garrow TA, Zeisel SH. Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem 2011; 286:36258–36267. [31]

▪▪. Tsuchiya M, Ji C, Kosyk O, et al. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology 2012; 56:130–139. [28]

▪. Wang YC, Chen YM, Lin YJ, et al. GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation. Mol Med 2011; 17:486–494. [37]

▪. Watson WH, Song Z, Kirpich IA, et al. Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system. Biochim Biophys Acta 2011; 1812:613–618. [08]

Back to Top | Article Outline
Detection of amino acid deprivation in the central nervous system

Review: (pp. 96–101)

▪. Cheng Y, Zhang Q, Meng Q, et al. Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Mol Endocrinol 2011; 25:1624–1635. [34]

Di Prisco S, Summa M, Chellakudam V, Rossi PIA, et al. RANTES-mediated control of excitatory amino acid release in mouse spinal cord. J Neurochem 2012; 121:428–437.

▪. Gietzen DW, Aja SM. The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal. Molec Neurobiol 2012 [ePub 07 June]. [14]

▪. Gloaguen M, Le Floc'h N, Corrent E, et al. Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and alpha-keto acid concentrations in pigs. J Anim Sci 2012. [05]

▪▪. Gosby AK, Conigrave AD, Lau NS, et al. Testing protein leverage in lean humans: a randomised controlled experimental study. PloS One 2011; 6:e25929. [27]

Helms HC, Madelung R, Waagepetersen HS, Nielsen CU, et al. In vitro evidence for the brain glutamate efflux hypothesis: Brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate. Glia 2012; 60:882–893. View Full Text | PubMed | CrossRef

Marmiroli P, Cavaletti G. The Glutamatergic Neurotransmission in the Central Nervous System. Curr Med Chem 2012; 19:1269–1276. PubMed | CrossRef

▪. Morrison CD, Reed SD, Henagan TM. Homeostatic regulation of protein intake: in search of a mechanism. Am J Physiol 2012; 302:R917–928. [20]

Musgrave T, Tenorio G, Rauw G, Baker GB, et al. Tissue concentration changes of amino acids and biogenic amines in the central nervous system of mice with experimental autoimmune encephalomyelitis (EAE). Neurochem Int 2011; 59:28–38. View Full Text | PubMed | CrossRef

▪. Nakahara K, Takata S, Ishii A, et al. Somatostatin is involved in anorexia in mice fed a valine-deficient diet. Amino Acids 2012; 42:1397–1404. [24]

▪▪. Plaisance EP, Greenway FL, Boudreau A, et al. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metabol 2011; 96:E836–840. [29]

▪▪. Rudell JB, Rechs AJ, Kelman TJ, et al. The anterior piriform cortex is sufficient for detecting depletion of an indispensable amino acid, showing independent cortical sensory function. J Neurosci 2011; 31:1583–1590. [11]

Seib TM, Patel SA, Bridges RJ. Regulation of the System x(C)(-) Cystine/Glutamate Exchanger by Intracellular Glutathione Levels in Rat Astrocyte Primary Cultures. Glia 2011; 59:1387–1401. PubMed

Back to Top | Article Outline
The nutritional burden of methylation reactions

Review: (pp. 102–108)

▪. Cordero P, Gomez-Uriz AM, Campion J, et al. Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. Genes Nutr 2012. doi: 10.1007/s12263-012-0300-z. [Epub ahead of print] [50]

Kalhan SC, Edmison J, Marczewski S, Dasarathy S, et al. Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine. Clin Sci 2011; 121:179–189. PubMed | CrossRef

▪. Lamers Y, Coats B, Ralat M, et al. Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women. J Nutr 2011; 141:835–842. [34]

Lee JH, Park GH, Lee YK, Park JH. Changes in the arginine methylation of organ proteins during the development of diabetes mellitus. Diabetes Res Clin Pract 2011; 94:111–118. PubMed | CrossRef

▪. Lever M, George PM, Elmslie JL, et al. Betaine and secondary events in an acute coronary syndrome cohort. PLoS One 2012; 7:e37883. [32]

▪. Stover PJ, Field MS. Trafficking of intracellular folates. Adv Nutr 2011; 2:325–331. [05]

▪▪. Wilson FA, Holtrop G, Calder AG, et al. Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat. Am J Physiol Endocrinol Metab 2012; 302:E1531–E1540. [28]

▪. Zhou YH, Tang JY, Wu MJ, et al. Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis. PLoS One 2011; 6:e25142. [31]

© 2013 Lippincott Williams & Wilkins, Inc.

Login