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Role of cholesterol metabolism in the pathogenesis of Alzheimer's disease

Allinquant, Bernadette; Clamagirand, Christine; Potier, Marie-Claude

Current Opinion in Clinical Nutrition & Metabolic Care: July 2014 - Volume 17 - Issue 4 - p 319–323
doi: 10.1097/MCO.0000000000000069
GENES AND CELL METABOLISM: Edited by Philip Newsholme and Paulo Ivo Homem de Bittencourt Jr

Purpose of review Cholesterol has been shown to stimulate the cleavage of amyloid precursor protein (APP) into amyloid peptides involved in Alzheimer's disease. However, high level of peripheral cholesterol as a risk factor for Alzheimer's disease is still debated. This current review provides an update of the recent literature on cholesterol and APP metabolisms in the brain.

Recent findings First, a new relationship between neuronal APP and cholesterol has been shown in which this protein controls cholesterol turnover required for neuronal activity. Second, oxysterols are able to stimulate the synthesis of ATP-binding cassette transporters involved in the exchange of amyloid peptides between the blood and the brain. Third, changes in APP targeting to lipid rafts and/or their composition in cholesterol regulate amyloid peptide production.

Summary These recent findings open new areas of investigations to control the neuronal activity and to decrease the amyloid peptide levels in brain, opening on new preventive and therapeutic strategies for Alzheimer's disease.

aINSERM UMR 894, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine

bInstitut du Cerveau et de la Moelle, UPMC, INSERM UMR S 975, CNRS UMR 7225, Paris, France

Correspondence to Dr Bernadette Allinquant, INSERM UMR 894, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris 75014, France. Tel: +33 1 407 892 41; fax: +33 1 458 072 93; e-mail: bernadette.allinquant@inserm.fr

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