You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Role of cholesterol metabolism in the pathogenesis of Alzheimer's disease

Allinquant, Bernadettea; Clamagirand, Christinea; Potier, Marie-Claudeb

Current Opinion in Clinical Nutrition & Metabolic Care:
doi: 10.1097/MCO.0000000000000069
GENES AND CELL METABOLISM: Edited by Philip Newsholme and Paulo Ivo Homem de Bittencourt Jr
Abstract

Purpose of review: Cholesterol has been shown to stimulate the cleavage of amyloid precursor protein (APP) into amyloid peptides involved in Alzheimer's disease. However, high level of peripheral cholesterol as a risk factor for Alzheimer's disease is still debated. This current review provides an update of the recent literature on cholesterol and APP metabolisms in the brain.

Recent findings: First, a new relationship between neuronal APP and cholesterol has been shown in which this protein controls cholesterol turnover required for neuronal activity. Second, oxysterols are able to stimulate the synthesis of ATP-binding cassette transporters involved in the exchange of amyloid peptides between the blood and the brain. Third, changes in APP targeting to lipid rafts and/or their composition in cholesterol regulate amyloid peptide production.

Summary: These recent findings open new areas of investigations to control the neuronal activity and to decrease the amyloid peptide levels in brain, opening on new preventive and therapeutic strategies for Alzheimer's disease.

Author Information

aINSERM UMR 894, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine

bInstitut du Cerveau et de la Moelle, UPMC, INSERM UMR S 975, CNRS UMR 7225, Paris, France

Correspondence to Dr Bernadette Allinquant, INSERM UMR 894, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris 75014, France. Tel: +33 1 407 892 41; fax: +33 1 458 072 93; e-mail: bernadette.allinquant@inserm.fr

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins