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Fatty acids regulation of inflammatory and metabolic genes

Masi, Laureane N.a; Rodrigues, Alice C.b; Curi, Ruia

Current Opinion in Clinical Nutrition & Metabolic Care: July 2013 - Volume 16 - Issue 4 - p 418–424
doi: 10.1097/MCO.0b013e32836236df
GENES AND CELL METABOLISM: Edited by Lynette R. Ferguson and Philip Newsholme

Purpose of review Fatty acids influence human health and diseases in various ways. In recent years, much work has been carried out to elucidate the mechanisms by which dietary fatty acids control short-term and long-term cellular functions. We have reviewed herein the most recent studies on modulation of gene expression by fatty acids. A number of genes respond to transcription factors and present a transcription factor response element in their promoter regions. Fatty acids may exert their effects on metabolism by regulating gene transcription via transcription factors. Understanding how fatty acids control expression of metabolic genes is a promising strategy to be investigated by aiming to treat metabolic diseases such as insulin resistance, obesity, and type 2 diabetes mellitus.

Recent findings Fatty acids exert many of their biological effects through the modulation of the activity of transcription factors, such as sterol regulatory element-binding proteins, peroxisome proliferator-activated receptors, and liver X receptors.

Summary Fatty acid action through transcription factors controls the expression of several inflammatory and metabolic genes.

aDepartment of Physiology and Biophysics

bDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

Correspondence to Rui Curi, Institute of Biomedical Sciences, Av. Professor Lineu Prestes, 1524, 05508–900 São Paulo, Brazil. Tel: +55 11 3091 7245; e-mail: ruicuri@icb.usp.br

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins