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Current Opinion in Clinical Nutrition & Metabolic Care:
doi: 10.1097/MCO.0b013e328357f63b
MICRONUTRIENTS: Edited by Gil Hardy and Henry Lukaski

Inflammation and diminished iron status: mechanisms and functional outcomes

Gaffney-Stomberg, Erin; McClung, James P.

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Abstract

Purpose of review: To summarize recent findings regarding the effects of inflammation on iron (Fe) metabolism and to review studies detailing the influence of poor Fe status on physical and cognitive performance.

Recent findings: Hepatic expression and release of hepcidin, a negative regulator of Fe status, is increased by the actions of the inflammatory cytokine interleukin-6. Inflammation associated with chronic disease, obesity, and exercise is associated with elevated interleukin-6 and hepcidin levels, which may result in diminished Fe status.

Summary: Decrements in Fe status due to insufficient dietary Fe intake and/or the inflammatory response may degrade physical and cognitive performance. Future studies should clarify whether dietary or other therapeutic interventions to mitigate inflammation attenuate hepcidin-mediated declines in Fe status.

© 2012 Lippincott Williams & Wilkins, Inc.

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