Skip Navigation LinksHome > July 2010 - Volume 13 - Issue 4 > Neurobiology of food addiction
Current Opinion in Clinical Nutrition & Metabolic Care:
doi: 10.1097/MCO.0b013e32833ad4d4
Genes and cell metabolism: Edited by Nada Abumrad and Samuel Klein

Neurobiology of food addiction

Blumenthal, Daniel Ma; Gold, Mark Sb

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Purpose of review: To review recent work on disorders related to food use, including food addiction, and to highlight the similarities and differences between food and drugs of abuse.

Recent findings: Recent work on food use disorders has demonstrated that the same neurobiological pathways that are implicated in drug abuse also modulate food consumption, and that the body's regulation of food intake involves a complex set of peripheral and central signaling networks. Moreover, new research indicates that rats can become addicted to certain foods, that men and women may respond differently to external food cues, and that the intrauterine environment may significantly impact a child's subsequent risk of developing obesity, diabetes, and hypercholesterolemia.

Summary: First, work presented in this review strongly supports the notion that food addiction is a real phenomenon. Second, although food and drugs of abuse act on the same central networks, food consumption is also regulated by peripheral signaling systems, which adds to the complexity of understanding how the body regulates eating, and of treating pathological eating habits. Third, neurobiological research reviewed here indicates that traditional pharmacological and behavioral interventions for other substance-use disorders may prove useful in treating obesity.

© 2010 Lippincott Williams & Wilkins, Inc.


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