You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Amino acid metabolism in liver disease

Holm, Eggert; Sedlaczek, Oliver; Grips, Eva

Current Opinion in Clinical Nutrition & Metabolic Care:
Review Article
Abstract

The impairment of transsulphuration during methionine degradation in hepatic failure can be counteracted by treatment with S-adenosylmethionine. Regarding the pathogenesis of hepatic encephalopathy, no convincing evidence exists for tryptophan, glutamine or glutamate being involved. Portal-systemic shunting-induced hyperammonaemia may reduce plasma branched-chain amino acids. The glucose effect on urea synthesis does not exist in cirrhosis.

Author Information

Department of Pathophysiology, Medical Clinic I Mannheim, University of Heidelberg, Germany

Correspondence to Professor Dr Eggert Holm, Department of Pathophysiology, Medical Clinic I, Theodor Kutzer Ufer, D-68167 Mannheim, Germany Tel: +49 621 3832643; fax: +49 621 3832191; e-mail: eggert.holm@urz.uniheidelberg.de

© 1999 Lippincott Williams & Wilkins, Inc.