Skip Navigation LinksHome > July 2013 - Volume 28 - Issue 4 > High-density lipoprotein cholesterol raising: does it matte...
Current Opinion in Cardiology:
doi: 10.1097/HCO.0b013e328362210d
LIPIDS AND HEART DISEASE: Edited by Anthony S. Wierzbicki and Dimitri P. Mikhailidis

High-density lipoprotein cholesterol raising: does it matter?

Schofield, Jonathan D.a,b; France, Michaela,b,c; Ammori, Basilb,d; Liu, Yifenb; Soran, Handreana,b,e

Collapse Box


Purpose of review: Cardiovascular disease (CVD) is the leading cause of morbidity and premature mortality in Europe and the United States, and is increasingly common in developing countries. High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for CVD and is superior to low-density lipoprotein cholesterol (LDL-C) as a predictor of cardiovascular events. The residual risk conferred by low HDL-C in patients with a satisfactory LDL-C was recently highlighted by the European Atherosclerosis Society. Despite the lack of randomized controlled trials, it has been suggested that raising the level of HDL-C should be considered as a therapeutic strategy in high-risk patients because of the strong epidemiological evidence, compelling biological plausibility, and both experimental and clinical research supporting its cardioprotective effects.

Recent findings: Three recent large randomized clinical trials investigating the effect of HDL-C raising with niacin and dalcetrapib in statin-treated patients failed to demonstrate an improvement in cardiovascular outcomes.

Summary: There is evidence to support the view that HDL functionality and the mechanism by which a therapeutic agent raises HDL-C are more important than plasma HDL-C levels. Future therapeutic agents will be required to improve this functionality rather than simply raising the cholesterol cargo.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.