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Current Opinion in Anaesthesiology:
doi: 10.1097/ACO.0b013e3283393977
Pediatric anaesthesia: Edited by Walid Habre

Can inhalation agents be used in the presence of a child with myopathy?

Veyckemans, Francis

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Purpose of review: Anaesthesia for a child with a muscle disease is always challenging because there is a risk of malignant hyperthermia, rhabdomyolysis or hypermetabolic reaction if a halogenated agent is used. Ongoing progress in genetics helps in clarifying the link between malignant hyperthermia (a calcium channelopathy) and muscle diseases.

Recent findings: We provide a summary of the most recent clinical, pathophysiological and genetic information on those risks when the diagnosis is known or suspected preoperatively. Some simple clues are also given to help make a decision in the presence of an infant or child with hypotonia or motor delay but no diagnosis.

Summary: Only a few muscle diseases are really associated with a risk of malignant hyperthermia. The risk of rhabdomyolysis is more difficult to clarify and a multicentric database would be useful to evaluate the risk/benefit ratio of all anaesthetic drugs in patients with muscle diseases.

© 2010 Lippincott Williams & Wilkins, Inc.


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