Skip Navigation LinksHome > August 2008 - Volume 21 - Issue 4 > Sex, age, and genetics in anesthesia
Current Opinion in Anaesthesiology:
doi: 10.1097/ACO.0b013e3283007ea3
Drugs in anesthesia: Edited by Alan D. Kaye

Sex, age, and genetics in anesthesia

Booij, Leo HDJ

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Abstract

Purpose of review: Pharmacology is one of the corner stones of anesthesia. Outcome of anesthesia is related, in part, to both pharmacodynamics and pharmacokinetics of anesthetic drugs. Recent developments have indicated that among individuals, major differences exist in pharmacological effects. In this regard, sex, age, and genetic profile are increasingly considered to be of importance.

Recent findings: For a number of anesthetic drugs, it has been demonstrated that sex differences influence their effects and thus can alter the outcome of anesthesia. Also other genetically determined differences than sex are important.

Summary: In the future, it is expected that an individual's pharmacological needs will be based on age, sex, and genomics.

© 2008 Lippincott Williams & Wilkins, Inc.

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