Skip Navigation LinksHome > April 2014 - Volume 14 - Issue 2 > Engineered nanomaterial exposure and the risk of allergic di...
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0000000000000031
OCCUPATIONAL DISEASE: Edited by Susan M. Tarlo and Piero Maestrelli

Engineered nanomaterial exposure and the risk of allergic disease

Shannahan, Jonathan H.; Brown, Jared M.

Collapse Box


Purpose of review: Although the production and use of engineered nanomaterials (ENMs) is rapidly increasing, we lack sufficient knowledge regarding their capacity to induce and/or promote allergic disease. As novel ENMs are being developed and used for biomedical applications, such as drug delivery, it will be critical to understand the relationship between physicochemical properties of ENMs and possible mechanisms of immunomodulation.

Recent findings: Cellular studies and a few animal studies have begun to examine the immunomodulatory effects of ENM exposure that may be predictive of developing allergic reactions. Specifically, the effects of direct ENM exposure on key immune cells recognized to facilitate allergic disease has been evaluated and will be discussed. However, few studies have reported specific physicochemical properties of ENMs that initiate allergic immune responses. Although limited, these descriptive studies point to the induction of cellular mechanisms that are well known to promote allergic disease.

Summary: The limited data currently available suggest that there is a potential risk for the development of allergic responses following exposure to ENMs. As more ENMs are developed for consumer products and nanomedicines, further study on their potential for adverse immune interactions will be necessary for safe implementation of these novel materials.

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.