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Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0000000000000026
RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

The association between acetaminophen and asthma: is there anything to learn from the upper airways?

Kim, Haejin; Johnson, Christine C.

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Purpose of review: To examine the literature evidence for the association between acetaminophen (paracetamol) use and development of rhinitis.

Recent findings: Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma. There is a paucity of well designed birth cohort studies to examine paracetamol as a risk factor in the development of rhinitis. Confounding by antibiotic use, viral infections, and recall bias are problematic for many of the studies that are published.

Summary: Prospective birth cohorts need to dedicate sufficient time and research personnel to adequately assess paracetamol exposure as a primary variable of interest rather than as an incidental exposure variable collected during routine questionnaire administration.

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.


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