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Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0000000000000026
RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

The association between acetaminophen and asthma: is there anything to learn from the upper airways?

Kim, Haejina; Johnson, Christine C.b

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Abstract

Purpose of review

To examine the literature evidence for the association between acetaminophen (paracetamol) use and development of rhinitis.

Recent findings

Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma. There is a paucity of well designed birth cohort studies to examine paracetamol as a risk factor in the development of rhinitis. Confounding by antibiotic use, viral infections, and recall bias are problematic for many of the studies that are published.

Summary

Prospective birth cohorts need to dedicate sufficient time and research personnel to adequately assess paracetamol exposure as a primary variable of interest rather than as an incidental exposure variable collected during routine questionnaire administration.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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